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Relationship Between Dissolution Rate in Vitro and Absorption Rate in Vivo of Ketamine Prolonged-Release Tablets
Background and ObjectivesUnderstanding the processes that determine the time course of drug absorption rates is of great interest. This study aims to...
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Evaluation of microstructure, dissolution rate, and oral bioavailability of paclitaxel poloxamer 188 solid dispersion
Poor solubility is a major challenge for enhancing the oral bioavailability and clinical application of many drugs, including the broad-spectrum...
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A Refined Thin-Film Model for Drug Dissolution Considering Radial Diffusion – Simulating Powder Dissolution
PurposeWe aim to present a refined thin-film model describing the drug particle dissolution considering radial diffusion in spherical boundary layer,...
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Surface Characterization as a Tool for Identifying the Factors Affecting the Dissolution Rate of Amorphous Solid Dispersion Tablets
An amorphous solid dispersion (ASD) is a commonly used approach to enhancing the dissolution of poorly aqueous soluble drugs. Selecting the desired...
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Combining Liquisolid and Co-grinding Techniques to Enhance the Dissolution Rate of Celecoxib
PurposeThe classic liquisolid technique is used to enhance the dissolution rate of poorly water-soluble drugs, but in some cases, it is impossible to...
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Preparation and Evaluation of Berberine-Excipient Complexes in Enhancing the Dissolution Rate of Berberine Incorporated into Pellet Formulations
Berberine is used in the treatment of metabolic syndrome and its low solubility and very poor oral bioavailability of berberine was one of the...
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PhysioCell — a Novel, Bio-relevant Dissolution Apparatus: Hydrodynamic Conditions and Factors Influencing the Dissolution Dynamics
The physiologically relevant dissolution apparatuses simulate various aspects of gastrointestinal physiology and help to understand and predict the in...
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Time-Lapse Macro Imaging with Dissolution Tests for Exploring the Interrelationship Between Disintegration and Dissolution Behaviors of Solid Dosages
ObjectiveThis study aims to establish a Flow-through Visualization Dissolution System (FVDS) that combines time-lapse macro-imaging and a...
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A Potential Breakthrough in the Enhancement of Glimepiride Solubility and Dissolution Rate by Binary and Ternary Solid Dispersion Technique and In Vitro Comparison with Marketed Formulation
PurposeGlimepiride, an anti-diabetic and third-generation sulfonylurea drug belonging to class II BCS (Biopharmaceutical Classification System) type,...
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Combination of co-crystal and nanocrystal techniques to improve the solubility and dissolution rate of poorly soluble drugs
PurposeSolubility and dissolution rate are essential for the oral absorption and bioavailability of poorly soluble drugs. The aim of this study was...
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Enhancement of Solubility and Dissolution Rate Using Tailored Rapidly Dissolving Oral Films Containing Felodipine Solid Dispersion: In Vitro Characterization and Ex Vivo Studies
PurposeThe goal of the present investigation was to establish felodipine (FDP) solid dispersion-loaded transmucosal buccal films which may help to...
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Coupling Drug Dissolution with BCS
PurposeThe purpose of this study is to develop a Temporal Biopharmaceutic Classification System (T-BCS), linking Finite Dissolution Time (F.D.T.) and...
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Quercetin-Loaded Mesoporous Silica Nanoparticle–Based Lyophilized Tablets for Enhanced Physicochemical Features and Dissolution Rate: Formulation, Optimization, and In Vitro Evaluation
Mesoporous silica nanoparticles (MSNPs) have been proposed as a potential approach for stabilizing the amorphous state of poorly water-soluble...
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Increase in Dissolution Rate of Zotepine via Nanomilling Process — Impact of Dried Nanocrystalline Suspensions on Bioavailability
Zotepine is an atypical antipsychotic drug used in the treatment of schizophrenia. However, its poor dissolution properties limit its therapeutic...
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Effects of Apex Size on Dissolution Profiles in the USP II Paddle Apparatus
The use of apex vessels may solve coning problems associated with dissolution testing. However, excessive dissolution acceleration can reduce the...
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Discriminative Dissolution Method Development Through an aQbD Approach
Using a one-factor-at-a-time approach for dissolution method and discrimination analysis can be time-consuming and may not yield the optimal and...
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Enhancement of Valsartan Dissolution Rate by the Increased Porosity of Pellets Using Supercritical CO2: Optimization via Central Composite Design
PurposeThe aim of this research was to optimize the enhancement the porosity of pellet containing valsartan (VAL) using carbon dioxide at...
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Effect of Food Viscosity on Drug Dissolution
PurposeThe purpose of the present study was to investigate the effect of food viscosity on the dissolution rate of a drug. There are two types of...
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Drug Dissolution in Oral Drug Absorption: Workshop Report
The in-person workshop “Drug Dissolution in Oral Drug Absorption” was held on May 23–24, 2023, in Baltimore, MD, USA. The workshop was organized into...
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Solubility vs Dissolution in Physiological Bicarbonate Buffer
BackgroundPhosphate buffer is often used as a replacement for the physiological bicarbonate buffer in pharmaceutical dissolution testing, although...
