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A preliminary study on the reference intervals of serum tumor marker in apparently healthy elderly population in southwestern China using real-world data
BackgroundThe aim is to establish and verify reference intervals (RIs) for serum tumor markers for an apparently healthy elderly population in...
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Combination of alpha-fetoprotein and neutrophil-to-lymphocyte ratio to predict treatment response and survival outcomes of patients with unresectable hepatocellular carcinoma treated with immune checkpoint inhibitors
BackgroundImmune-checkpoint inhibitors (ICIs) have revolutionized the treatment of hepatocellular carcinoma (HCC). However, long-term survival...
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Adjuvant sintilimab in resected high-risk hepatocellular carcinoma: a randomized, controlled, phase 2 trial
Hepatocellular carcinoma (HCC), particularly when accompanied by microvascular invasion (MVI), has a markedly high risk of recurrence after liver...
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Surveillance and treatment of primary hepatocellular carcinoma (aka. STOP HCC): protocol for a prospective cohort study of high-risk patients for HCC using GALAD-score
BackgroundVietnam and Saudi Arabia have high disease burden of primary hepatocellular carcinoma (HCC). Early detection in asymptomatic patients at...
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Enzymatic Biosensor Platforms for Non-infectious Diseases: Diagnosis of Metabolic Disorders
Rapid and accurate diagnoses of diseases are important determinants required for optimal improvements in public health. Conventional in vitro...
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Identifying novel transcript biomarkers for hepatocellular carcinoma (HCC) using RNA-Seq datasets and machine learning
BackgroundHepatocellular carcinoma (HCC) is one of the leading causes of cancer death in the world owing to limitations in its prognosis. The current...
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Identification and monitoring of mutations in circulating cell-free tumor DNA in hepatocellular carcinoma treated with lenvatinib
BackgroundThere has been a recent surge in interest in predicting biological effects associated with genomic alterations in order to implement...
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Purification and functional characterization of lectin from Chenopodium album
Chenopodium album L. is a nutritious and edible vegetable with various health benefits. It has been traditionally used for the treatment of several...
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Serum fibroblast growth factor 19 serves as a potential novel biomarker for hepatocellular carcinoma
BackgroundAbnormal autocrine fibroblast growth factor 19 (FGF19) production has been observed in several types of cancers, including hepatocellular...
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Serum levels of anti-heat shock protein 27 antibodies in patients with chronic liver disease
Heat shock protein 27 (HSP27), an intracellular molecular chaperone, is involved in the pathogenesis of cancer by promoting both tumor cell...
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Circulating small extracellular vesicle-derived splicing factor 3b subunit 4 as a non-invasive diagnostic biomarker of early hepatocellular carcinoma
BackgroundHepatocellular carcinoma (HCC) accounts for a majority of primary liver cancer cases and related deaths. The purpose of this study was to...
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Serum lnc34a is a potential prediction biomarker for bone metastasis in hepatocellular carcinoma patients
BackgroundEarly screening and intervention therapies are crucial to improve the prognosis of hepatocellular carcinoma (HCC) patients with bone...
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Blood Constituents and Safety Pharmacology: In Vitro and In Vivo Thrombosis and Hemostasis Assays
Thrombosis and related disorders represent the number one cause of mortality. The understanding of the mechanisms behind the pathogenesis of venous...
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Serum epidermal growth factor-like domain 7 serves as a novel diagnostic marker for early hepatocellular carcinoma
BackgroundEpidermal growth factor-like domain 7 (Egfl7), a recently identified secreted protein, was significantly increased in patients with HCC by...
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Biomarkers for Monitoring the Immunotherapy Response to Cancer
Numerous physiological samples are employed to find cancer biomarkers before the beginning of clinical signs. Different forms of cancer biomarkers...
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Impact of continued administration of tolvaptan on cirrhotic patients with ascites
BackgroundThe vasopressin V2-receptor antagonist tolvaptan is used to treat cirrhotic patients with ascites. We investigated the outcome of long-term...
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Prediction of vascular invasion in hepatocellular carcinoma by next-generation des-r-carboxy prothrombin
Background:In hepatocellular carcinoma (HCC), des-r-carboxy prothrombin (DCP) more accurately reflects the malignant potential than alpha-fetoprotein...
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Signaling pathways in liver cancer: pathogenesis and targeted therapy
Liver cancer remains one of the most prevalent malignancies worldwide with high incidence and mortality rates. Due to its subtle onset, liver cancer...
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A robust twelve-gene signature for prognosis prediction of hepatocellular carcinoma
BackgroundThe prognosis of hepatocellular carcinoma (HCC) patients remains poor. Identifying prognostic markers to stratify HCC patients might help...
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Tuberculosis: current scenario, drug targets, and future prospects
Globally recognized genetic modification with time has supported the emergence of versatile and novel featured organisms in nature, some of which can...
