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Effects of cytochalasin D on relaxation process of skinned taenia cecum and carotid artery from guinea pig
Actin linked regulatory mechanisms are known to contribute contraction/relaxation in smooth muscle. In order to clarify whether modulation of...
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BioID Analysis of Actin-Binding Proteins
Proteins often exist and function as part of higher-order complexes or networks. A challenge is to identify the universe of proximal and interacting...
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Gasdermin D membrane pores orchestrate IL-1α secretion from necrotic macrophages after NFS-rich silica exposure
IL-1α is an intracellular danger signal (DAMP) released by macrophages contributing to the development of silica-induced lung inflammation. The exact...
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RhoA suppresses pseudorabies virus replication in vitro
The porcine pseudorabies virus (PRV) is one of the most devastating pathogens and brings great economic losses to the swine industry worldwide....
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Development of a micronucleus test using the EpiAirway™ organotypic human airway model
BackgroundThe use of organotypic human tissue models in genotoxicity has increased as an alternative to animal testing. Genotoxicity is generally...
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Defining Endocytic Pathways of Fucoidan-Coated PIBCA Nanoparticles from the Design of their Surface Architecture
PurposeThis work investigated the endocytic pathways taken by poly(isobutylcyanoacrylate) (PIBCA) nanoparticles differing in their surface...
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Mechanisms of deoxynivalenol-induced endocytosis and degradation of tight junction proteins in jejunal IPEC-J2 cells involve selective activation of the MAPK pathways
Mycotoxin contamination in foods is a major risk factor for human and animal health due to its prevalence in cereals and their by-products....
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Metabolites from Fungi: A Promising Source of Lead Compounds Against Cancer
The diversity of fungi represents a fabulous and remarkable asset of sources of bioactive compounds with vast potential for pharmaceutical...
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Quantitative Investigation of Neuroprotective Role of ROR1 in a Cell Culture Model of Alzheimer’s Disease
Cytoskeletal and microtubule atrophy are major hallmarks of Alzheimer’s disease (AD). A method to investigate endogenous proteins that can...
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Fungal Endophytes: An Accessible Natural Repository for Discovery of Bioactive Compounds
Microorganisms are proficient synthesizers of natural product molecules that are often bioactive and a source of various antibiotics and other...
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A Ciliary Branched Actin Network Drives Photoreceptor Disc Morphogenesis
The light-detecting organelle of the photoreceptor cell is a modified primary cilium, called the outer segment. The outer segment houses hundreds of...
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Internalization of benzylisoquinoline alkaloids by resting and activated bone marrow-derived mast cells utilizes energy-dependent mechanisms
Objective and designDrug delivery to inflammatory cells is dependent upon poorly understood, complex endocytic processes. Berberine (BBR), a...
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Glia maturation factor beta deficiency protects against diabetic osteoporosis by suppressing osteoclast hyperactivity
Excessive osteoclast activation, which depends on dramatic changes in actin dynamics, causes osteoporosis (OP). The molecular mechanism of osteoclast...
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Recent Advances in Pharmaceutically Important Compounds from Endophytic Fungi
The study of endophytic fungi as a source of new bioactive molecules is an area that has grown very much within the chemistry of natural products,...
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Coronavirus and the Cytoskeleton of Virus-Infected Cells
The cytoskeleton, which includes actin filaments, microtubules, and intermediate filaments, is one of the most important networks in the cell and...
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The movement of mitochondria in breast cancer: internal motility and intercellular transfer of mitochondria
As a major energy source for cells, mitochondria are involved in cell growth and proliferation, as well as migration, cell fate decisions, and many...
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Fate of micronuclei and micronucleated cells after treatment of HeLa cells with different genotoxic agents
Although micronuclei are well-known biomarkers of genotoxic damage, the biological consequences of micronucleus induction are only poorly understood....
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Recent Advances in Anti-Infective Compounds Produced by Endophytic Fungi
Endophyte is the combined form of two Greek words, which are endon (i.e. within) and phyto (i.e. plants). Endophytic microorganisms (mainly bacteria...
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Supplementing Glucose Intake Reverses the Inflammation Induced by a High-Fat Diet by Increasing the Expression of Siglec-E Ligands on Erythrocytes
Siglec-9/E is a cell surface receptor expressed on immune cells and can be activated by sialoglycan ligands to play an immunosuppressive role. Our...
