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Bioinformatics analysis revealed the potential crosstalk genes and molecular mechanisms between intracranial aneurysms and periodontitis
ObjectivesThe risk of intracranial aneurysms (IAs) development and rupture is significantly higher in patients with periodontitis (PD), suggesting an...
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Vascular calcification: from the perspective of crosstalk
Vascular calcification (VC) is highly correlated with cardiovascular disease morbidity and mortality, but anti-VC treatment remains an area to be...
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Nutrient sensors and their crosstalk
The macronutrients glucose, lipids, and amino acids are the major components that maintain life. The ability of cells to sense and respond to...
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Crosstalk between long noncoding RNA and microRNA in Cancer
miRNAs and lncRNAs play a central role in cancer-associated gene regulations. The dysregulated expression of lncRNAs has been reported as a hallmark...
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Neuron-Microglia Crosstalk in Neuropsychiatric Disorders
Numerous studies have investigated the causes and mechanisms of psychiatric disorders through postmortem examination of patients with a history of a...
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The role of cellular and molecular neuroimmune crosstalk in gut immunity
The gastrointestinal tract is densely innervated by the peripheral nervous system and populated by the immune system. These two systems critically...
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NK cells are never alone: crosstalk and communication in tumour microenvironments
Immune escape is a hallmark of cancer. The dynamic and heterogeneous tumour microenvironment (TME) causes insufficient infiltration and poor efficacy...
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Stroke and Distal Organ Damage: Exploring Brain-Kidney Crosstalk
Stroke and kidney dysfunction represent significant public health challenges, yet the precise mechanisms connecting these conditions and their severe...
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Entosis: the core mechanism and crosstalk with other cell death programs
Cell death pathways play critical roles in organism development and homeostasis as well as in the pathogenesis of various diseases. While studies...
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Periostin–TGF-β feedforward loop contributes to tumour-stroma crosstalk in liver metastatic outgrowth of colorectal cancer
BackgroundThis study aimed to investigate the underlying mechanisms of matricellular protein periostin (POSTN) on tumour-stroma crosstalk in the...
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Crosstalk and plasticity driving between cancer-associated fibroblasts and tumor microenvironment: significance of breast cancer metastasis
Cancer-associated fibroblasts (CAFs) are the most abundant stromal cell population in breast tumors. A functionally diverse population of CAFs...
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FAS-mediated circRNA-miRNA-mRNA Crosstalk Network Regulates Immune Cell Infiltration in Cerebral Infarction
New data are accumulating on the involvement of interaction among circular RNAs (circRNAs), microRNAs (miRNAs/miRs), and messenger RNAs (mRNAs) in...
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Crosstalk Between Peripheral Innervation and Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive lethal malignancy, characterized by late diagnosis, aggressive growth, and therapy...
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Crosstalk between P2Y receptors and cyclooxygenase activity in inflammation and tissue repair
The role of extracellular nucleotides as modulators of inflammation and cell stress is well established. One of the main actions of these molecules...
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CTpathway: a CrossTalk-based pathway enrichment analysis method for cancer research
BackgroundPathway enrichment analysis (PEA) is a common method for exploring functions of hundreds of genes and identifying disease-risk pathways....
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Neuroimmune Crosstalk in the Tumor Microenvironment
Peripheral nerves have recently gained attention in cancer research due to their demonstrated ability to modify tumor microenvironment (TME) and...
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Disturbance of neuron–microglia crosstalk mediated by GRP78 in Neuropsychiatric systemic lupus erythematosus mice
ObjectivesNeuropsychiatric systemic lupus erythematosus (NPSLE) is a serious phenotype of systemic lupus erythematosus (SLE). The disturbance of...
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Development of a novel testis-on-a-chip that demonstrates reciprocal crosstalk between Sertoli and Leydig cells in testicular tissue
The reciprocal crosstalk between testicular Sertoli and Leydig cells plays a vital role in supporting germ cell development and maintaining...
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The potential crosstalk between tumor and plasma cells and its association with clinical outcome and immunotherapy response in bladder cancer
BackgroundAlthough immunotherapy is effective in improving the clinical outcomes of patients with bladder cancer (BC), it is only effective in a...
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Iron-Calcium Crosstalk in Neurodegenerative Diseases
Iron and calcium have one thing in common: they are both required for appropriate neural activity. Neuronal calcium impulses drive neurochemical...