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Increased cross-presentation by dendritic cells and enhanced anti-tumour therapy using the Arp2/3 inhibitor CK666
BackgroundDendritic cell (DC) vaccines for cancer therapy offer the possibility to let the patient’s own immune system kill cancer cells. However, DC...
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Anticipated time to seek medical advice for possible lung cancer symptoms and barriers to timely presentation in Palestine: a national cross-sectional study
BackgroundLung cancer (LC) has poor survival outcomes mainly due to diagnosis at late stages. This study explored the anticipated time to seek...
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Anticipated time to seek medical advice for possible ovarian cancer symptoms and perceived barriers to early presentation among Palestinian women: a national cross-sectional study
BackgroundSeveral factors contribute to delayed presentation with ovarian cancer (OC) symptoms including poor symptom awareness and barriers to...
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Hematological, clinical, cytogenetic and molecular profiles of confirmed chronic myeloid leukemia patients at presentation at a tertiary care teaching hospital in Addis Ababa, Ethiopia: a cross-sectional study
BackgroundIn low-income countries there is insufficient evidence on hematological, clinical, cytogenetic and molecular profiles among new CML...
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TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming
Classic major histocompatibility complex class I (MHC-I) presentation relies on shuttling cytosolic peptides into the endoplasmic reticulum (ER) by...
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Frequency of viral infections in adolescent and adult in-patient Ethiopians with acute leukemia at presentation to a tertiary care teaching hospital: a cross-sectional study
BackgroundLeukemic patients are prone to infectious agents such as viruses due to dysregulated immune system resulting from infiltration of the bone...
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Prevalence of late-stage presentation and associated factors of cervical cancer patients in Tikur Anbesa Specialized Hospital, Ethiopia: institutional based cross-sectional study
BackgroundCancer of the uterine cervix remains a main public health problem in Sub-Saharan Africa. About two-thirds of patients with cervical cancer...
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The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens
Type 1 conventional dendritic (cDC1) cells are necessary for cross-presentation of many viral and tumor antigens to CD8 + T cells. cDC1 cells can be...
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Publisher Correction: The receptor DNGR-1 signals for phagosomal rupture to promote cross-presentation of dead-cell-associated antigens
A Correction to this paper has been published: https://doi.org/10.1038/s41590-021-00885-6.
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FcRn regulates antigen presentation in dendritic cells downstream of DEC205-targeted vaccines
Dendritic cell (DC)-targeted vaccination is a new mode of antigen delivery that relies on the use of monoclonal antibodies (mAb) to target antigen to...
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Advanced-stage presentation of cancer at the time of diagnosis and its associated factors among adult cancer patients at Northwest Amhara comprehensive specialized hospitals, Northwest Ethiopia 2022
IntroductionScreening of cancer is the maximum effort and critical element for providing health related care in order to decrease cancer related...
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Prostate cancer in New York City: impact of neighborhood level social determinants of care
Social determinants of health may impact prostate cancer presentation. Since neighborhoods may influence adjacent neighborhoods across often porous...
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Plant-derived virus-like particle vaccines drive cross-presentation of influenza A hemagglutinin peptides by human monocyte-derived macrophages
A growing body of evidence supports the importance of T cell responses to protect against severe influenza, promote viral clearance, and ensure...
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Tissue-resident memory T cells break tolerance to renal autoantigens and orchestrate immune-mediated nephritis
Immune-mediated nephritis is a leading cause of acute kidney injury and chronic kidney disease. While the role of B cells and antibodies has been...
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Immunization against Zika by entrap** live virus in a subcutaneous self-adjuvanting hydrogel
The threat of new viral outbreaks has heightened the need for ready-to-use vaccines that are safe and effective. Here we show that a subcutaneous...
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Association of Sport Helmet Status on Concussion Presentation and Recovery in Male Collegiate Student-Athletes
Sporting helmets contain force attenuating materials which reduce traumatic head injury risk and may influence sport-related concussion (SRC)...
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Neutralizing Antibody Sample Testing and Report Harmonization
Immunogenicity testing and characterization is an important part of understanding the immune response to administration of a protein therapeutic....
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A systematic safety pipeline for selection of T-cell receptors to enter clinical use
Cancer immunotherapy using T cell receptor-engineered T cells (TCR-Ts) represents a promising treatment option. However, technologies for...
