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Tumor Suppressor Genes and Cell Fate Control
In this chapter, we will present the transcription factor p53, which is encoded by the most prominent cancer driver gene, the tumor suppressor gene...
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Cell Fate Analysis and Machine Learning
One of the most intriguing and fundamental questions in developmental biology is in the domain of understanding of cell fate, molecular mechanisms,...
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Radiotherapy modulates tumor cell fate decisions: a review
Cancer has always been a worldwide problem, and the application of radiotherapy has greatly improved the survival rate of cancer patients....
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Regulation of stem cell fate by HSPGs: implication in hair follicle cycling
Heparan sulfate proteoglycans (HSPGs) are part of proteoglycan family. They are composed of heparan sulfate (HS)-type glycosaminoglycan (GAG) chains...
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Interplay Between Zika Virus-Induced Autophagy and Neural Stem Cell Fate Determination
The Zika virus (ZIKV) outbreaks and its co-relation with microcephaly have become a global health concern. It is primarily transmitted by a mosquito,...
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New insights into the epitranscriptomic control of pluripotent stem cell fate
Each cell in the human body has a distinguishable fate. Pluripotent stem cells are challenged with a myriad of lineage differentiation options....
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Systematic identification of cell-fate regulatory programs using a single-cell atlas of mouse development
Waddington’s epigenetic landscape is a metaphor frequently used to illustrate cell differentiation. Recent advances in single-cell genomics are...
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How germ granules promote germ cell fate
Germ cells are the only cells in the body capable of giving rise to a new organism, and this totipotency hinges on their ability to assemble...
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Emerging role of the RNA-editing enzyme ADAR1 in stem cell fate and function
Stem cells are critical for organism development and the maintenance of tissue homeostasis. Recent studies focusing on RNA editing have indicated how...
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Enhancer–promoter interactions become more instructive in the transition from cell-fate specification to tissue differentiation
To regulate expression, enhancers must come in proximity to their target gene. However, the relationship between the timing of enhancer–promoter...
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Epigenetic recording of stimulation history reveals BLIMP1–BACH2 balance in determining memory B cell fate upon recall challenge
Memory B cells (MBCs) differentiate into plasma cells (PCs) or germinal centers (GCs) upon antigen recall. How this decision is programmed is not...
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Machine learning-based classification of dual fluorescence signals reveals muscle stem cell fate transitions in response to regenerative niche factors
The proper regulation of muscle stem cell (MuSC) fate by cues from the niche is essential for regeneration of skeletal muscle. How pro-regenerative...
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Three-dimensional genome organization in immune cell fate and function
Immune cell development and activation demand the precise and coordinated control of transcriptional programmes. Three-dimensional (3D) organization...
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Effects of toxicants on endoplasmic reticulum stress and hepatic cell fate determination
Toxicant-induced injury is a significant global health issue. However, the mechanisms through which toxicants such as carbon tetrachloride,...
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Smooth muscle cell fate decisions decipher a high-resolution heterogeneity within atherosclerosis molecular subtypes
BackgroundMounting evidence has revealed the dynamic variations in the cellular status and phenotype of the smooth muscle cell (SMC) are vital for...
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Reversal of the T cell immune system reveals the molecular basis for T cell lineage fate determination in the thymus
T cell specificity and function are linked during development, as MHC-II-specific TCR signals generate CD4 helper T cells and MHC-I-specific TCR...
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Beyond metabolic waste: lysine lactylation and its potential roles in cancer progression and cell fate determination
BackgroundLactate is an important metabolite derived from glycolysis under physiological and pathological conditions. The Warburg effect reveals the...
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Repertoire analyses reveal T cell antigen receptor sequence features that influence T cell fate
T cells acquire a regulatory phenotype when their T cell antigen receptors (TCRs) experience an intermediate- to high-affinity interaction with a...
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Ribonucleotide reductase M2B in the myofibers modulates stem cell fate in skeletal muscle
The balance among quiescence, differentiation, and self-renewal of skeletal muscle stem cells (MuSCs) is tightly regulated by their intrinsic and...
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DNA replication fork speed underlies cell fate changes and promotes reprogramming
Totipotency emerges in early embryogenesis, but its molecular underpinnings remain poorly characterized. In the present study, we employed DNA fiber...
