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Invasion and Metastatic Potential of Cancer Stem Cells In Vitro
In order to fight against cancer, it is critical to study cellular migration, invasion, and adhesion, which are the pivotal steps of metastasis....
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Targeting cholesterol impairs cell invasion of all breast cancer types
BackgroundBreast cancer clinical outcome relies on its intrinsic molecular subtype and mortality is almost exclusively due to metastasis, whose...
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Invasion and Metastasis
This chapter delineates processes, molecules, and interactions contributing to invasion and metastasis, the most defining properties of malignancy....
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PLK1 phosphorylates RhoGDI1 and promotes cancer cell migration and invasion
BackgroundRho guanine nucleotide dissociation inhibitor 1 (RhoGDI1) plays an important role in diverse cellular processes by regulating Rho guanosine...
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Neural Influence on Cancer Invasion and Metastasis
Nerves modulate the surrounding tissue to facilitate nerve repair and regeneration. This fascinating regenerative ability is demonstrated in case of...
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The depth of perineural invasion is an independent prognostic factor for stage II colorectal cancer
BackgroundPerineural invasion (PNI) is the invasion of nerves by cancer cells and is associated with poor survival in stage II colorectal cancer....
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Invasion und Metastasierung
Dieses Kapitel beschreibt Prozesse, Moleküle und Wechselwirkungen, die zur Invasion und Metastasierung beitragen, die am stärksten definierenden...
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Perineural invasion in colorectal cancer: mechanisms of action and clinical relevance
BackgroundIn recent years, the significance of the nervous system in the tumor microenvironment has gained increasing attention. The bidirectional...
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IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/β-catenin signaling
ObjectivesPreviously, Interferon-induced Protein with Tetratricopeptide Repeats 1 (IFIT1) has been shown to promote cancer development. Here, we...
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CSGALNACT2 restricts ovarian cancer migration and invasion by modulating MAPK/ERK pathway through DUSP1
PurposeOvarian cancer is one of the leading causes of cancer-related death among women. CSGALNACT2 is a vital Golgi transferase and is related to a...
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TRIM8 Promotes Proliferation, Invasion, and Migration of Cervical Cancer Cells by Ubiquitinating and Degrading SOCS1
Cervical cancer (CC) is a malignant tumor primarily caused by the persistent infection with high-risk strains of human papillomavirus. This study...
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MAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor
BackgroundThe Mitogen-activated protein kinase 1 (MAPK1) has both independent functions of phosphorylating histones as a kinase and directly binding...
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linc01152 Regulates Cell Viability, Cell Migration and Cell Invasion of Breast Cancer via Regulating miR-320a and MTDH
Breast cancer is a global disease and a cause of cancer-related deaths in women. Long non-coding RNAs (lncRNAs) perform important functions in...
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Hypoxia- and Postirradiation reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent manner
BackgroundCancer cells in severely hypoxic regions have been reported to invade towards tumour blood vessels after surviving radiotherapy in a...
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Water channel protein AQP1 in cytoplasm is a critical factor in breast cancer local invasion
BackgroundMetastasis of breast cancer grows from the local invasion to the distant colonization. Blocking the local invasion step would be promising...
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Matrine inhibits invasion and migration of gallbladder cancer via regulating the PI3K/AKT signaling pathway
Gallbladder cancer (GBC) is a common malignant cancer in the biliary system, which poses a serious threat to human health. It is urgent to explore...
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CD147 promotes breast cancer migration and invasion by inducing epithelial-mesenchymal transition via the MAPK/ERK signaling pathway
BackgroundCD147, a transmembrane glycoprotein, has been implicated in various cancer-related processes but its role in breast cancer remains poorly...
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The Long Non-Coding RNA ENST00000494165 Influence Papillary Thyroid Cancer Cell Proliferation and Invasion
Long noncoding RNAs (lncRNAs) have recently been identified as crucial biomarkers of papillary thyroid cancer (PTC). In this study, we aimed to...
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CD151-enriched migrasomes mediate hepatocellular carcinoma invasion by conditioning cancer cells and promoting angiogenesis
BackgroundThe tetraspanin family plays a pivotal role in the genesis of migrasomes, and Tetraspanin CD151 is also implicated in neovascularization...
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The Long Noncoding RNA Gall Bladder Cancer-Associated Suppressor of Pyruvate Carboxylase Inhibits the Proliferation, Migration, and Invasion of Colorectal Cancer Cells and Induces Their Apoptosis
This study aimed to determine the role of the long noncoding RNA (lncRNA) gall bladder cancer-associated suppressor of pyruvate carboxylase (SOD2-1)...
