Search
Search Results
-
Characterization of novel CD19-specific VHHs isolated from a camelid immune library by phage display
BackgroundMonoclonal antibody (mAb)-based immunotherapies have achieved promising outcomes in the treatment of immunological and oncological...
-
A comprehensive comparison between camelid nanobodies and single chain variable fragments
By the emergence of recombinant DNA technology, many antibody fragments have been developed devoid of undesired properties of natural...
-
Single-Domain Antibody-Gold Nanoparticle Bioconjugates as Immunosensors for the Detection of Hantaviruses
IntroductionHantavirus, a zoonotic pathogen, causes severe syndromes like hemorrhagic fever with renal syndrome (HFRS), sometimes fatal in humans....
-
Camelid Single-Domain Antibodies for the Development of Potent Diagnosis Platforms
The distinct biophysical and pharmaceutical properties of camelid single-domain antibodies, referred to as VHHs or nanobodies, are associated with...
-
Structural Classification of CDR-H3 in Single-Domain VHH Antibodies
The immune systems protect vertebrates from foreign molecules or antigens, and antibodies are important mediators of this system. The sequences and...
-
Camelid Single-Domain Antibodies for Targeting Cancer Nanotheranostics
Single-domain antibodies (VHHs), in particular those engineered from the variable heavy-chain fragment (VHH gene) found in Camelidae heavy-chain...
-
Antibody Affinity Maturation Using Computational Methods: From an Initial Hit to Small-Scale Expression of Optimized Binders
Nanobodies (VHHs) are engineered fragments of the camelid single-chain immunoglobulins. The VHH domain contains the highly variable segments...
-
Isolation of Antigen-Specific VHH Single-Domain Antibodies by Combining Animal Immunization with Yeast Surface Display
In addition to conventional hetero-tetrameric antibodies, the adaptive immune repertoire of camelids comprises the so-called heavy chain-only...
-
A Dual Target-Directed Single Domain-Based Fusion Protein Against Interleukin-6 Receptor Decelerate Experimental Arthritis Progression Via Modulating JNK Expression
The currently used anti-cytokine therapeutic antibodies cannot selectively neutralize pathogenic cytokine signalling that cause collateral damage to...
-
Identification of Nanobodies Blocking Intimate Adherence of Shiga Toxin-Producing Escherichia coli to Epithelial Cells
Therapeutic antibodies (Abs) inhibiting bacterial adhesion to host epithelia are an attractive option to reduce the load of Shiga toxin-producing E....
-
Structure-based design and construction of a synthetic phage display nanobody library
ObjectiveTo design and construct a new synthetic nanobody library using a structure-based approach that seeks to maintain high protein stability and...
-
Camels’ biological fluids contained nanobodies: promising avenue in cancer therapy
Cancer is a major health concern and accounts for one of the main causes of death worldwide. Innovative strategies are needed to aid in the diagnosis...
-
The Potential of Nanobodies for COVID-19 Diagnostics and Therapeutics
The infectious severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent for coronavirus disease 2019 (COVID-19). Globally,...
-
Mechanisms and research advances in mRNA antibody drug-mediated passive immunotherapy
Antibody technology is widely used in the fields of biomedical and clinical therapies. Nonetheless, the complex in vitro expression of recombinant...
-
Nanobodies; new molecular instruments with special specifications for targeting, diagnosis and treatment of triple-negative breast cancer
Breast cancer is the most common type of cancer in women and the second leading cause of cancer death in female. Triple-negative breast cancer has a...
-
Nanobodies: a tool to open new horizons in diagnosis and treatment of prostate cancer
BackgroundProstate cancer is one of the most common cancers in men and its incidence has increased dramatically in the last decade. This increase in...
-
Mouse embryonic stem cell-derived blood–brain barrier model: applicability to studying antibody triggered receptor mediated transcytosis
Blood brain barrier (BBB) models in vitro are an important tool to aid in the pre-clinical evaluation and selection of BBB-crossing therapeutics....
-
Recombinant Antibody Fragments for Immunotherapy of Parkinson’s Disease
Parkinson’s disease (PD) is the second most common age-related neurodegenerative disorder. Multiple genetic and environmental factors leading to...
-
Pharmacokinetics and Pharmacodynamic Effect of a Blood-Brain Barrier-Crossing Fusion Protein Therapeutic for Alzheimer’s Disease in Rat and Dog
PurposeWe have recently demonstrated the brain-delivery of an Amyloid-ß oligomer (Aßo)-binding peptide-therapeutic fused to the BBB-crossing single...
-
Marine-derived microbes and molecules for drug discovery
Increasing attention has been paid to marine-derived biomolecules as sources of therapeutics for autoimmune diseases. Nagasaki Prefecture has many...
