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The Brain and the Immune System
The function and different layers of the immune system for the whole body are described. The notion of the brain as an “immune privileged site” is...
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The Gut Microbiome-Induced Changes in Brain Immune System and Their Role in Epilepsy
Patients of all ages can experience unpredictable, spontaneous, and uncontrollable seizures as a result of the severe neurological condition called...
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Chronic social defeat alters brain vascular-associated cell gene expression patterns leading to vascular dysfunction and immune system activation
Brain vascular integrity is critical for brain health, and its disruption is implicated in many brain pathologies, including psychiatric disorders....
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Vivaria housing conditions expose sex differences in brain oxidation, microglial activation, and immune system states in aged hAPOE4 mice
Apolipoprotein E ε4 allele (APOE4) is the predominant genetic risk factor for late-onset Alzheimer’s disease (AD). APOE4 mouse models have provided...
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Targeting brain-peripheral immune responses for secondary brain injury after ischemic and hemorrhagic stroke
The notion that the central nervous system is an immunologically immune-exempt organ has changed over the past two decades, with increasing evidence...
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Role of Maternal Immune Factors in Neuroimmunology of Brain Development
Inflammation during pregnancy may occur due to various factors. This condition, in which maternal immune system activation occurs, can affect fetal...
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The contribution of the meningeal immune interface to neuroinflammation in traumatic brain injury
Traumatic brain injury (TBI) is a major cause of disability and mortality worldwide, particularly among the elderly, yet our mechanistic...
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Correlation of Immune-Inflammatory Response System (IRS)/Compensatory Immune-Regulatory Reflex System (CIRS) with White Matter Integrity in First-Episode Patients with Schizophrenia
Several studies have reported compromised white matter integrity, and that some inflammatory mediators may underlie this functional dysconnectivity...
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Brain Immune Cell Infiltration and Serum Metabolomic Characteristics Reveal that Lauric Acid Promotes Immune Cell Infiltration in Brain and Streptococcus suis Meningitis in Mice
Although naturally Streptococcus suis serotype 2 (SS2) causes meningitis resulting in death or sequela of neurological symptoms in pigs and humans,...
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PTSD, Immune System, and Inflammation
Posttraumatic stress disorder (PTSD) is a severe trauma and stress-related disorder associated with different somatic comorbidities, especially...
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Disease and brain region specific immune response profiles in neurodegenerative diseases with pure and mixed protein pathologies
The disease-specific accumulation of pathological proteins has long been the major focus of research in neurodegenerative diseases (ND), including...
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Immune System Cells
In sum, neuroimmunology has progressed from studies looking at the detrimental roles of immune cells in neuroinflammation and their surveillance...
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Bi-directional neuro-immune dysfunction after chronic experimental brain injury
BackgroundIt is well established that traumatic brain injury (TBI) causes acute and chronic alterations in systemic immune function and that systemic...
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Dissecting the Immune System through Gene Regulation
The immune system plays a dual role in human health, functioning both as a protector against pathogens and, at times, as a contributor to disease....
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Interactions Between Endogenous Opioids and the Immune System
The endogenous opioid system, which consists of opioid receptors and their ligands, is widely expressed in the nervous system and also found in the...
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An aging-related immune landscape in the hematopoietic immune system
BackgroundAging is a holistic change that has a major impact on the immune system, and immunosenescence contributes to the overall progression of...
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Cellular and Molecular Roles of Immune Cells in the Gut-Brain Axis in Migraine
Migraine is a complex and multi-system dysfunction. The realization of its pathophysiology and diagnosis is develo** rapidly. Migraine has been...
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Multiomic spatial landscape of innate immune cells at human central nervous system borders
The innate immune compartment of the human central nervous system (CNS) is highly diverse and includes several immune-cell populations such as...
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Immune cell infiltration and inflammatory landscape in primary brain tumours
BackgroundPrimary malignant brain tumours are more than one-third of all brain tumours and despite the molecular investigation to identify cancer...
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Role of Serotonergic System in Regulating Brain Tumor-Associated Neuroinflammatory Responses
Serotonin signaling regulates wide arrays of both neural and extra-neural functions. Serotonin is also found to affect cancer progression directly as...