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Delayed Outgrowth in Response to the BDNF and Altered Synaptic Proteins in Neurons From SHR Rats
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity...
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Hemodynamic Parameters in Spontaneously Hypertensive Rats with Obesity and Chemically Induced Colitis during Probiotic Therapy
We studied the dynamics of the main hemodynamic parameters in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats with visceral obesity...
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Acacetin inhibits myocardial mitochondrial dysfunction by activating PI3K/AKT in SHR rats fed with fructose
To explore the effect of acacetin on myocardial mitochondrial dysfunction in spontaneously hypertensive rats (SHR) with insulin resistance (IR), and...
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Changes in Kolmer Cells in SHR Rats after Cerebral Ischemia
Kolmer cells (epiplexus macrophages) constitute the least studied population among the phagocytosing cells in the mammalian brain. We report here...
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Effects of reversible SERCA inhibition on catecholamine exocytosis and intracellular [Ca2+] signaling in chromaffin cells from normotensive Wistar Kyoto rats and spontaneously hypertensive rats
Intracellular Ca 2+ ([Ca 2+ ]i) signaling and catecholamine (CA) exocytosis from adrenal chromaffin cells (CCs) differ between mammalian species. These...
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Effects of Chronic Hypertension on the Energy Metabolism of Cerebral Cortex Mitochondria in Normotensive and in Spontaneously Hypertensive Rats During Aging
In this study the subcellular modifications undergone by cerebral cortex mitochondrial metabolism in chronic hypertension during aging were...
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Spontaneously hypertensive rats can become hydrocephalic despite undisturbed secretion and drainage of cerebrospinal fluid
BackgroundHydrocephalus constitutes a complex neurological condition of heterogeneous origin characterized by excessive cerebrospinal fluid (CSF)...
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Influence of a Decrease in Blood Viscosity on Arterial Pressure in Normotensive and Spontaneously Hypertensive Rats
We investigated the effect of a decrease in blood viscosity on the mean BP during isovolumic hemodilution and vasodilating activity of the...
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Expression of Bax and Bcl-2 Proteins in Left-Ventricular Cardiomyocytes in Wistar-Kyoto and SHR Rats with Insulin-Dependent Diabetes Mellitus
Loss of cardiomyocytes due to apoptotic or necrotic death is an important component of the pathogenesis of heart failure. Initiation of apoptosis by...
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Antihypertensive Effects of a Soluble Guanylate Cyclase Stimulator
We studied antihypertensive activity of an indolinone derivative (compound GRS), a soluble guanylate cyclase stimulator and a drug with previously...
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Effect of Sex on Structural and Morphological Parameters of Rat Heart under Conditions of Combined Exposure to Hypokinesia and Cold
We studied the combined effect of hypokinesia and external cooling on structural and morphological changes in the ventricular myocardium and...
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Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects
Inflammatory activation and oxidative stress promote the proliferation of vascular smooth muscle cells (VSMCs), which accounts for pathological...
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Motor Activity and Levels of Expression of mRNA for the Proteins NAP-22 and GAP-43 in Spontaneously Hypertensive Rats
The aim of the present work was to identify differences in movement activity in SHR and WKY rats and to assess the levels of expression of mRNA for...
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Microbiota-derived acetate attenuates neuroinflammation in rostral ventrolateral medulla of spontaneously hypertensive rats
BackgroundIncreased neuroinflammation in brain regions regulating sympathetic nerves is associated with hypertension. Emerging evidence from both...
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Open-loop analysis on sympathetically mediated arterial pressure and urine output responses in spontaneously hypertensive rats: effect of renal denervation
Primary acute sympathetic activation (PASA) causes a subsequent arterial pressure (AP) elevation. In this case, an antidiuretic effect via the renal...
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Development of the hypersecretory phenotype in the population of adrenal chromaffin cells from prehypertensive SHRs
The hypersecretory phenotype of adrenal chromaffin cells (CCs) from early spontaneously hypertensive rats (SHRs) mainly results from enhanced Ca 2+ -ind...
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Sex- and age-related differences in renal and cardiac injury and senescence in stroke-prone spontaneously hypertensive rats
BackgroundSex differences play a critical role in the incidence and severity of cardiovascular diseases, whereby men are at a higher risk of...
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Upregulation of Glutamatergic Receptors in Hippocampus and Locomotor Hyperactivity in Aged Spontaneous Hypertensive Rat
Epidemiologic studies have indicated that chronic hypertension may facilitate the progression of abnormal behavior, such as emotional irritability,...
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Characteristics of Inflammatory and Normal Endothelial Exosomes on Endothelial Function and the Development of Hypertension
Endothelial dysfunction is associated with the development of hypertension. We hypothesize that inflammatory and normal endothelial exosomes play...
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The effects of the dopamine D2/3 agonist quinpirole on incentive value and palatability-based choice in a rodent model of attention-deficit/hyperactivity disorder
RationalePalatability and incentive value influence animal food choice. Dopamine D2/3 receptor signaling may mediate the effects of palatability and...
