We investigated the effect of a decrease in blood viscosity on the mean BP during isovolumic hemodilution and vasodilating activity of the endothelium in normotensive Wistar rats and spontaneously hypertensive rats (SHR). Blood viscosity was reduced by isovolumic hemodilution (replacement of 10% of circulating blood with an equal volume of plasma). Hemodilution caused the same reduction in blood viscosity by 16% in both groups of rats. In Wistar rats, a decrease in blood viscosity did not significantly change in the mean BP; no significant correlations between blood viscosity and mean BP were observed before and after hemodilution. In SHR, a decrease in blood viscosity led to a significant decrease in the mean BP by 18%. Correlations were found between the mean BP and blood viscosity in SHR before (r=0.63; p=0.028) and after (r=0.71; p=0.009) isovolumic hemodilution. In SHR, a decrease in the index of vasodilating activity of the endothelium due to a decrease in the vasodilatory response to intravenous administration of the endothelium-dependent vasodilator acetylcholine was revealed. In SHR, BP passively follows the change, in this case, the decrease in blood viscosity, which attests to impaired BP regulation in response to changes in shear stress on the vascular endothelium caused by the development of endothelial dysfunction in hypertensive animals.
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Meiselman HJ, Baskurt OK. Hemorheology and hemodynamics: Dove andare? Clin. Hemorheol. Microcirc. 2006;35(1-2):37-43.
Valeanu L, Ginghina C, Bubenek-Turconi S. Blood rheology alterations in patients with cardiovascular diseases. Rom. J. Anaesth. Intensive Care. 2022;28(2):41-46. doi: https://doi.org/10.2478/rjaic-2021-0007
Sloop G, Holsworth RE Jr, Weidman JJ, St Cyr JA. The role of chronic hyperviscosity in vascular disease. Ther. Adv. Cardiovasc. Dis. 2015;9(1):19-25. doi: https://doi.org/10.1177/1753944714553226
Ciuffetti G, Pasqualini L, Pirro M, Lombardini R, De Sio M, Schillaci G, Mannarino E. Blood rheology in men with essential hypertension and capillary rarefaction. J. Hum. Hypertens. 2002;16(8):533-537. doi: https://doi.org/10.1038/sj.jhh.1001454
Forconi S, Gori T. The evolution of the meaning of blood hyperviscosity in cardiovascular physiopathology: should we reinterpret Poiseuille? Clin. Hemorheol. Microcirc. 2009;42(1):1-6. doi: https://doi.org/10.3233/CH-2009-1186
Salazar Vázquez BY, Martini J, Chávez Negrete A, Tsai AG, Forconi S, Cabrales P, Johnson PC, Intaglietta M. Cardiovascular benefits in moderate increases of blood and plasma viscosity surpass those associated with lowering viscosity: Experimental and clinical evidence. Clin. Hemorheol. Microcirc. 2010;44(2):75-85. doi: https://doi.org/10.3233/CH-2010-1261
Martini J, Carpentier B, Negrete AC, Frangos JA, Intaglietta M. Paradoxical hypotension following increased hematocrit and blood viscosity. Am. J. Physiol. Heart Circ. Physiol. 2005;289(5):H2136-H2143. doi: https://doi.org/10.1152/ajpheart.00490.2005
Bonnin P, Vilar J, Levy BI. Effect of normovolemic hematocrit changes on blood pressure and flow. Life Sci. 2016;157:62-66. doi: https://doi.org/10.1016/j.lfs.2016.01.050
Konukoglu D, Uzun H. Endothelial dysfunction and hypertension. Adv. Exp. Med. Biol. 2017;956:511-540. doi: https://doi.org/10.1007/5584_2016_90
Cahill PA, Redmond EM. Vascular endothelium — Gatekeeper of vessel health. Atherosclerosis. 2016;248:97-109. doi: https://doi.org/10.1016/j.atherosclerosis.2016.03.007
da Silva GM, da Silva MC, Nascimento DVG, Lima Silva EM, Gouvêa FFF, de França Lopes LG, Araújo AV, Ferraz Pereira KN, de Queiroz TM. Nitric oxide as a central molecule in hypertension: focus on the vasorelaxant activity of new nitric oxide donors. Biology (Basel). 2021;10(10):1041. doi: https://doi.org/10.3390/biology10101041
Tang EH, Vanhoutte PM. Endothelial dysfunction: a strategic target in the treatment of hypertension? Pflugers Arch. 2010;459(6):995-1004. doi: https://doi.org/10.1007/s00424-010-0786-4
Weil BR, Stauffer BL, Greiner JJ, DeSouza CA. Prehypertension is associated with impaired nitric oxide-mediated endothelium-dependent vasodilation in sedentary adults. Am. J. Hypertens. 2011;24(9):976-981. doi: https://doi.org/10.1038/ajh.2011.88
Maio R, Suraci E, Caroleo B, Politi C, Gigliotti S, Sciacqua A, Andreozzi F, Perticone F, Perticone M. New-onset diabetes, endothelial dysfunction, and cardiovascular outcomes in hypertensive patients: an illness-event model analysis. Biomedicines. 2021;9(7):721. doi: https://doi.org/10.3390/biomedicines9070721
Hawk TC, Leary, ST, Morris, TH. Formulary for Laboratory Animals, 3rd ed. Ames, IA Blackwell Publishing, 2005.
Laursen JB, Boesgaard S, Poulsen HE, Aldershvile J. Nitrate tolerance impairs nitric oxide-mediated vasodilation in vivo. Cardiovasc. Res. 1996;31(5):814-819. doi: https://doi.org/10.1016/0008-6363(96)00027-2
Pokrovskij MV, Kochkarov VI, Pokrovskaja TG, Gladchenko MP, Artjushkova EB, Pashin EN, Brusnik MV, Chulukova TN, Kljavs JP, Korneev MM, Zelenkova TI, Malyhin VA, Belous AS, Zaloznyh JI, Majakov AI. Methodical approaches for the quantitative estimation of development endothelial dysfunction at L-NAME-the induced model of deficiency of nitric oxide in experiment. Kuban. Nauch. Med. Vestn. 2006;(10):72-77. Russian.
Bernatova I. Endothelial dysfunction in experimental mo-dels of arterial hypertension: cause or consequence? Biomed. Res. Int. 2014;2014:598271. doi: https://doi.org/10.1155/2014/598271
Puzserova A, Ilovska V, Balis P, Slezak P, Bernatova I. Age-related alterations in endothelial function of femoral artery in young SHR and WKY rats. Biomed. Res. Int. 2014;2014:658479. doi: https://doi.org/10.1155/2014/658479
Liu MH, ** HK, Floten HS, Yang Q, Yim AP, Furnary A, Zioncheck TF, Bunting S, He GW. Vascular endothelial growth factor-mediated endothelium-dependent relaxation is blunted in spontaneously hypertensive rats. J. Pharmacol. Exp. Ther. 2001;296(2):473-477.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 176, No. 10, pp. 412-416, October, 2023
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Sidekhmenova, A.V., Aliev, O.I., Anishchenko, A.M. et al. Influence of a Decrease in Blood Viscosity on Arterial Pressure in Normotensive and Spontaneously Hypertensive Rats. Bull Exp Biol Med 176, 419–422 (2024). https://doi.org/10.1007/s10517-024-06038-7
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DOI: https://doi.org/10.1007/s10517-024-06038-7