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Fusogenic vesicular stomatitis virus combined with natural killer T cell immunotherapy controls metastatic breast cancer
BackgroundMetastatic breast cancer is a leading cause of cancer death in woman. Current treatment options are often associated with adverse side...
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Community composition of black flies during and after the 2020 vesicular stomatitis virus outbreak in Southern New Mexico, USA
BackgroundVesicular stomatitis virus (VSV), a vector-borne pathogen of livestock, emerges periodically in the western US. In New Mexico (NM), US,...
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Modulation of the tumor microenvironment by armed vesicular stomatitis virus in a syngeneic pancreatic cancer model
BackgroundThe immunosuppressive microenvironment in pancreatic ductal adenocarcinoma is a major factor that limits the benefits of immunotherapy,...
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Prevalence, clinico-epidemiological features, and molecular characterization of bovine papular stomatitis virus in cattle in Iraq
Bovine papular stomatitis virus (BPSV) is a parapoxvirus that infects cattle, causing skin lesions on the udder and mouth. There have been few...
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The host cellular protein Ndufaf4 interacts with the vesicular stomatitis virus M protein and affects viral propagation
Vesicular stomatitis virus (VSV) is an archetypal member of Mononegavirales which causes important diseases in cattle, horses and pigs. The matrix...
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The rVSV-EBOV vaccine provides limited cross-protection against Sudan virus in guinea pigs
Recombinant vesicular stomatitis viruses (rVSVs) engineered to express heterologous viral glycoproteins have proven to be remarkably effective...
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Evaluation of SARS-CoV-2 neutralizing antibodies using a vesicular stomatitis virus possessing SARS-CoV-2 spike protein
BackgroundSARS-CoV-2 is a novel coronavirus that emerged in 2019 and is now classified in the genus Coronavirus with closely related SARS-CoV....
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YF17D-vectored Ebola vaccine candidate protects mice against lethal surrogate Ebola and yellow fever virus challenge
Ebola virus (EBOV) and related filoviruses such as Sudan virus (SUDV) threaten global public health. Effective filovirus vaccines are available only...
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A mutant vesicular stomatitis virus with reduced cytotoxicity and enhanced anterograde trans-synaptic efficiency
Understanding the connecting structure of brain network is the basis to reveal the principle of the brain function and elucidate the mechanism of...
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Pseudotyped Virus for Flaviviridae
Members of Flaviviridae are enveloped single positive-stranded RNA viruses including hepacivirus, pestivirus, pegivirus, and mosquito-transmitted...
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Single dose recombinant VSV based vaccine elicits robust and durable neutralizing antibody against Hantaan virus
Hantaan virus (HTNV) is a pathogenic orthohantavirus prevalent in East Asia that is known to cause hemorrhagic fever with severe renal syndrome...
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Product-Related Impurities in Therapeutic Virus Bioprocessing
Viral vectors are manufactured into drug products for therapeutic uses. Efforts must be undertaken to ensure sufficient understanding of the...
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Pseudotyped Virus for Henipavirus
The genus Henipavirus (HNV) includes two virulent infectious viruses, Nipah virus (NiV) and Hendra virus (HeV), which are the focus of considerable...
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Pseudotyped Virus for Bandavirus
The genus Bandavirus, belonging to family Phenuiviridae, order Bunyavirales, consists of eight tick-borne bunyaviruses. The Dabie bandavirus,...
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Infectious Virus Tracking by Fluorescent Live Cell Imaging in Primary Cells
To successfully infect a cell, HIV-1 has to overcome several host barriers while exploiting cellular cofactors. HIV-1 infection is highly inefficient...
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A single dose of a vesicular stomatitis virus-based influenza vaccine confers rapid protection against H5 viruses from different clades
The avian influenza virus outbreak in 1997 highlighted the potential of the highly pathogenic H5N1 virus to cause severe disease in humans....
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Identification of a conserved neutralizing epitope in Seneca Valley virus VP2 protein: new insight for epitope vaccine designment
BackgroundSeneca Valley virus (SVV) is a picornavirus that causes vesicular disease in swine. Clinical characteristics of the disease are similar to...
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Reassortment incompetent live attenuated and replicon influenza vaccines provide improved protection against influenza in piglets
Swine influenza A viruses (swIAV) cause an economically important respiratory disease in modern pig production. Continuous virus transmission and...
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Rhabdoviruses
Rabies virus is the most important member of the Rhabdoviridae family, which causes disease in humans. The family Rhabdoviridae is classified into...
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Lassa Virus Countermeasures
Lassa Fever (LF) is a viral hemorrhagic fever endemic in West Africa. LF begins with flu-like symptoms that are difficult to distinguish from other...