Search
Search Results
-
Differences and similarities in biophysical and biological characteristics between U87 MG glioblastoma and astrocyte cells
Current cancer studies focus on molecular-targeting diagnostics and interactions with surroundings; however, there are still gaps in characterization...
-
Bacoside a inhibits the growth of glioma by promoting apoptosis and autophagy in U251 and U87 cells
Bacoside A (gypenoside, Gyp) is a potent bioactive compound derived from Gynostemma pentaphyllum , known to exert inhibitory effects on various...
-
Capsaicin induces redox imbalance and ferroptosis through ACSL4/GPx4 signaling pathways in U87-MG and U251 glioblastoma cells
Glioblastoma is one of the deadliest malignant gliomas. Capsaicin is a homovanillic acid derivative that can show anti-cancer effects by regulating...
-
Novel vitamin K3 analogs containing 3-N-substituted aromatic and piperazine rings with selective in vitro anticancer activity against HeLa, U87 MG, and MCF-7 cells
In this study, firstly, novel vitamin K3 analogs were synthesized by the reactions of vitamin K3 (2-methyl-1,4-naphthoquinone, also known as...
-
WDR81 Gene Silencing Can Reduce Exosome Levels in Human U87-MG Glioblastoma Cells
Glioblastoma is a very invasive and prevalent brain tumor that affects 15 in 100,000 persons over the age of 70 years. Studies have shown that the...
-
4-Methoxydalbergione is a potent inhibitor of human astroglioma U87 cells in vitro and in vivo
Astroglioma is the most common primary tumor in the central nervous system without effective treatment strategies. Temozolomide (TMZ) is a...
-
In vivo antiangiogenic effect of nimbolide, trans-chalcone and piperine for use against glioblastoma
BackgroundAngiogenesis is an important hallmark of Glioblastoma (GBM) marked by elevated vascular endothelial growth factor-A (VEGF-A) and its...
-
Cell-specific modulation of mitochondrial respiration and metabolism by the pro-apoptotic Bcl-2 family members Bax and Bak
Proteins from the Bcl-2 family play an essential role in the regulation of apoptosis. However, they also possess cell death-unrelated activities that...
-
Profiling and Bioinformatics Analyses of Hypoxia-Induced Differential Expression of Long Non-coding RNA in Glioblastoma Multiforme Cells
Hypoxic microenvironments are intricately linked to malignant characteristics of glioblastoma multiforme (GBM). Long non-coding ribonucleic acids...
-
Characterization and comparison of human glioblastoma models
Glioblastoma (GBM) is one of the deadliest cancers. Treatment options are limited, and median patient survival is only several months. Translation of...
-
NCX2 Regulates Intracellular Calcium Homeostasis and Translocation of HIF-1α into the Nucleus to Inhibit Glioma Invasion
Glioma is the most common tumor of the central nervous system, and its poor prognosis can be linked to hypoxia and gene inactivation. Na + /Ca 2+ ...
-
Nitric Oxide Synthase Inhibition Prevents Cell Proliferation in Glioblastoma
Glioblastoma multiforme (GBM) is a prevalent and aggressive primary brain tumor, presenting substantial treatment challenges and high relapse rates....
-
Combined use of multiparametric high-content-screening and in vitro circadian reporter assays in neurotoxicity evaluation
Accumulating evidence indicates that chronic circadian rhythm disruption is associated with the development of neurodegenerative diseases induced by...
-
Characterization of LTr1 derived from cruciferous vegetables as a novel anti-glioma agent via inhibiting TrkA/PI3K/AKT pathway
Malignant glioma is the most fatal, invasive brain cancer with limited treatment options. Our previous studies show that...
-
3D tumor spheroids: morphological alterations a yardstick to anti-cancer drug response
Tumor spheroids are one of the well-characterized 3D culture systems bearing close resemblance to the physiological tissue organization and...
-
The Combination of 5-FU and Resveratrol Can Suppress the Growth of Glioblastoma Cells Through Downregulation of TRPM2 and β-Catenin
Glioblastoma multiforme (GBM) is the most common as well as the most fatal primary malignant tumor of the central nervous system (CNS), which still...
-
Alpha-1 antitrypsin expression is upregulated in multidrug-resistant cancer cells
Identification of the signature molecular profiles involved in therapy resistance is of vital importance in develo** new strategies for treatments...
-
S670, an amide derivative of 3-O-acetyl-11-keto-β-boswellic acid, induces ferroptosis in human glioblastoma cells by generating ROS and inhibiting STX17-mediated fusion of autophagosome and lysosome
Glioblastoma (GBM) is the most common malignant tumor in the brain with temozolomide (TMZ) as the only approved chemotherapy agent. GBM is...
-
Identification of genetic modifiers enhancing B7-H3-targeting CAR T cell therapy against glioblastoma through large-scale CRISPRi screening
BackgroundGlioblastoma multiforme (GBM) is a highly aggressive brain tumor with a poor prognosis. Current treatment options are limited and often...
-
Combining a noble gas with radiotherapy: glutamate receptor antagonist xenon may act as a radiosensitizer in glioblastoma
BackgroundIonotropic glutamate receptors α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) and N-methyl-D-aspartate receptor...
