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Galectin-3 and cancer immunotherapy: a glycobiological rationale to overcome tumor immune escape
Immunotherapy with checkpoint inhibitors (ICIs) has radically changed the landscape of therapeutic opportunities in oncology, but much still needs to...
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Hsa_circ_0136666 stimulates gastric cancer progression and tumor immune escape by regulating the miR-375/PRKDC Axis and PD-L1 phosphorylation
BackgroundTargeted drugs are not quite effective for prolonging the survival of patients with gastric cancer due to off-target effects as well as...
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AMPKα2 promotes tumor immune escape by inducing CD8+ T-cell exhaustion and CD4+ Treg cell formation in liver hepatocellular carcinoma
BackgroundAdenosine monophosphate-activated protein kinase (AMPK) is associated with the development of liver hepatocellular carcinoma (LIHC)....
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Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments
The malignant tumor is a multi-etiological, systemic and complex disease characterized by uncontrolled cell proliferation and distant metastasis....
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Tumor-associated macrophage-derived exosomes LINC01592 induce the immune escape of esophageal cancer by decreasing MHC-I surface expression
BackgroundTAMs (tumor-associated macrophages) infiltration promotes the progression of esophageal cancer (EC). However, the underlying mechanisms...
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Immune Escape Mechanism of Cancer
Purpose of ReviewCancer immune evasion is still a major obstacle in elimination of cancer cells and current cancer treatment. This review focuses on...
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Tumor Microenvironment and Immune Escape in the Time Course of Glioblastoma
Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor with a malignant prognosis. GBM is characterized by high cellular...
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Invasive FoxM1 phosphorylated by PLK1 induces the polarization of tumor-associated macrophages to promote immune escape and metastasis, amplified by IFITM1
BackgroundUnderstanding the mechanism behind immune cell plasticity in cancer metastasis is crucial for identifying key regulators. Previously we...
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Genetic immune escape landscape in primary and metastatic cancer
Studies have characterized the immune escape landscape across primary tumors. However, whether late-stage metastatic tumors present differences in...
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DNA hypermethylation driven by DNMT1 and DNMT3A favors tumor immune escape contributing to the aggressiveness of adrenocortical carcinoma
BackgroundAdrenocortical carcinoma is rare and aggressive endocrine cancer of the adrenal gland. Within adrenocortical carcinoma, a recently...
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Targeting RNA N6-methyladenosine modification: a precise weapon in overcoming tumor immune escape
Immunotherapy, especially immune checkpoint inhibitors (ICIs), has revolutionized the treatment of many types of cancer, particularly advanced-stage...
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Correlation of the tumor escape phenotype with loss of PRELP expression in melanoma
BackgroundDespite immunotherapies having revolutionized the treatment of advanced cutaneous melanoma, effective and durable responses were only...
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Immunological Landscape of Head and Neck Cancer: Mechanisms of Immune Escape and the Tumor Microenvironment
In order for transformed cells to form tumors, they must escape from the ongoing pressure of the immune system. Distinct changes within tumor cells...
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Immunosuppression, immune escape, and immunotherapy in pancreatic cancer: focused on the tumor microenvironment
Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is characterized by poor treatment response and low survival...
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Circular RNA circWWC3 augments breast cancer progression through promoting M2 macrophage polarization and tumor immune escape via regulating the expression and secretion of IL-4
Interaction between tumor cells and tumor microenvironment (TME) is critical to promote tumor progression and metastasis. As the most abundant immune...
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The Role of Intra-Tumor Hypoxia in Cancer Cells Immune Escape Mechanism
The tumor microenvironment (TME) is an intricate environment consisting of distinct cell types, aberrant vasculature, and immunosuppressive cytokines...
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Acidosis-mediated increase in IFN-γ-induced PD-L1 expression on cancer cells as an immune escape mechanism in solid tumors
Immune checkpoint inhibitors have revolutionized cancer therapy, yet the efficacy of these treatments is often limited by the heterogeneous and...
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Crosstalk between oxidative phosphorylation and immune escape in cancer: a new concept of therapeutic targets selection
BackgroundCancer is increasingly recognized as a metabolic disease, with evidence suggesting that oxidative phosphorylation (OXPHOS) plays a...
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KIR-based inhibitory CARs overcome CAR-NK cell trogocytosis-mediated fratricide and tumor escape
Trogocytosis is an active process that transfers surface material from targeted to effector cells. Using multiple in vivo tumor models and clinical...
