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Mutagenic Toxicity Testing
Genetic toxicology is a subspecialty of toxicology, which deals with identification, testing and analysis of substances which can cause damage to...
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Integrating rare genetic variants into DPYD pharmacogenetic testing may help preventing fluoropyrimidine-induced toxicity
Variability in genes involved in drug pharmacokinetics or drug response can be responsible for suboptimal treatment efficacy or predispose to adverse...
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Machine Learning for Predicting Organ Toxicity
Organ toxicity is a leading concern in safety assessment for regulatory agencies and pharmaceutical companies. Due to the huge amount of compounds...
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Scaffold Materials and Toxicity
Toxicity of scaffolds is the inherent property of scaffold materials and hence it invites great attention in tissue engineering and other biomedical...
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Preclinical Toxicity Studies
Preclinical toxicity studies involve testing the newly screened compounds to determine the safety of that compound in at least two different animal...
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Toxicity Assessment of Nanoparticle
The extensive applications of nanoparticles due to their unique physicochemical and biological properties have resulted in a surge in production and...
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Selected Methods for Toxicity Testing of Chemical and Biological Compounds Using Animals
Preclinical studies are an important stage in the development of every drug. They are the primary means of assessing the efficacy and safety of new...
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Adverse Outcome Pathways as Versatile Tools in Liver Toxicity Testing
Adverse outcome pathways (AOPs) are tools to capture and visualize mechanisms driving toxicological effects. They share a common structure consisting...
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General Design Considerations in Reproductive and Developmental Toxicity Studies
Developmental and reproductive toxicity studies are conducted with the objective of identifying adverse effects relevant to fertility, pregnancy and...
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Harnessing Human Pluripotent Stem Cell-Derived Pancreatic In Vitro Models for High-Throughput Toxicity Testing and Diabetes Drug Discovery
The long-standing goals in diabetes research are to improve β-cell survival, functionality and increase β-cell mass. Current strategies to manage...
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Can upfront DPYD extended variant testing reduce toxicity and associated hospital costs of fluoropyrimidine chemotherapy? A propensity score matched analysis of 2022 UK patients
AimTo independently assess the impact of mandatory testing using an extended DPYD variant panel (ToxNav®) and consequent dose adjustment of...
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Testing of Medical Devices
Medical device testing plays a vital role in ensuring the safety, efficacy, and quality of medical devices before they are introduced to the market....
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Species Selection for Pharmaceutical Toxicity Studies
Selecting the most appropriate animal species for toxicity testing increases the likelihood of detecting potential effects in humans. Regulatory...
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Approaches for In Silico Validation of Safety (Toxicity) Data for Cosmetics
It has been proven that computational approaches can be used to find endpoints that can help with a cosmetic safety assessment. Thousands of mice,...
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Toxicity: An Introduction
Toxicity induced by drug or chemicals may be life-threatening to human lives. Therefore a drug prior to human use should be tested for its toxic...