Abstract
It has been proven that computational approaches can be used to find endpoints that can help with a cosmetic safety assessment. Thousands of mice, guinea pigs, rats, and rabbits die each year due to torturous experiments. This paradigm shift has enabled the highest number of regulations of chemical safety assessments while also mandating the use of alternate methodologies, such as in silico approaches, whenever applicable, to evaluate different products for individual users from the US and Europe and other countries worldwide. Some people believe that animal testing is a reliable and quick approach to ensure that items are safe for human consumption as it helps to find the movement of the compound through the biological membrane and its action through it. There is also a practical realization well within the toxicity testing discipline that alternative techniques would not supersede in vivo models on a resembling scale. SEURAT-I was indeed a flagship project creating the academic and develo** foundations necessary to develop strategies to supplement conventional repeated dose systemic toxicity testing consumer monitoring with QSAR methods, read across frameworks, TTC approach, or other omics or other computational techniques. Alternative methods of testing and validating the toxicity of cosmetic products to animals must be incorporated into cosmetic industries to promote business ethics.
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Basu, T., Chugh, R., Gujjar, R.S., Upadhyay, A.K. (2023). Approaches for In Silico Validation of Safety (Toxicity) Data for Cosmetics. In: Pant, A.B., Dwivedi, A., Ray, R.S., Tripathi, A., Upadhyay, A.K., Poojan, S. (eds) Skin 3-D Models and Cosmetics Toxicity. Springer, Singapore. https://doi.org/10.1007/978-981-99-2804-0_11
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