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Characterization and Applications of Permeabilized Hepatocytes in Drug Discovery
Hepatocytes are one of the most physiologically relevant in vitro liver systems for human translation of clearance and drug-drug interactions (DDI)....
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Skeletal Muscle Relaxants
Skeletal muscle relaxants are used to achieve muscle relaxation during anesthesia and to treat conditions associated with muscle spasticity. These...
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Drug Repurposing for Spinal Cord Injury: Progress Towards Therapeutic Intervention for Primary Factors and Secondary Complications
Spinal cord injury (SCI) encompasses a plethora of complex mechanisms like the involvement of major cell death pathways, neurodegeneration of spinal...
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Influence of CYP2D6 and CYP2C19 genetic polymorphism on the pharmacokinetics of tolperisone in healthy volunteers
PurposeThis is the first study that connects pharmacokinetics of tolperisone with genetic polymorphism of the enzymes involved in its metabolism in...
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Drug-target based cross-sectional analysis of olfactory drug effects
BackgroundDrug effects on the human sense of smell attract increasing interest, yet systematic evidence from controlled studies is sparse. The...
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Modulation of oxidative stress as an anticancer strategy
The regulation of oxidative stress is an important factor in both tumour development and responses to anticancer therapies. Many signalling pathways...
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Psychiatric symptoms of patients with primary mitochondrial DNA disorders
BackgroundThe aim of our study was to assess psychiatric symptoms in patients with genetically proven primary mutation of the mitochondrial DNA.
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Genetic and proteomic approaches to identify cancer drug targets
While target-based small-molecule discovery has taken centre-stage in the pharmaceutical industry, there are many cancer-promoting proteins not...
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Human pharmacokinetics of the muscle relaxant, eperisone hydrochloride by liquid chromatography–electrospray tandem mass spectrometry
Eperisone hydrochloride (4′-ethyl-2-methyl-3-piperidinopropiophenone hydrochloride) is a muscle relaxant agent, widely used in the treatment of...
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Voltage-gated sodium channel blockers, 2001-2006: An overview
Voltage-gated sodium channel blockers have long been used in the therapy of various central nervous system diseases, including epilepsy, chronic...
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The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine
RationaleClozapine is a unique antipsychotic, with efficacy against positive symptoms in treatment-resistant schizophrenic patients, and the ability...
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Intestinal First-Pass Metabolism of Eperisone in the Rat
Purpose . The purpose of this study was to clarify quantitatively the contribution of the intestine to the first-pass metabolism of eperisone in rats.Methods... -
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New findings and symptomatic treatment for neurolathyrism, a motor neuron disease occurring in North West Bangladesh
Neurolathyrism is a form of spastic paraparesis caused by the neuroexcitatory amino acid 3-N-oxalyl-L-2,3-diaminopropanoic acid (β-ODAP) present in...
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A study of adverse effects on the progeny after intoxication during pregnancy
The pregnancy outcomes of 109 women who were intoxicated during pregnancy due to excessive amounts of drugs and other agents were studied. Seventy...
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The uncertainty principal in vision
During research into the relationship between the bandpass width of the spatial frequency characteristic (ΔF) and the size (D) of the receptive field...
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Antinociceptive action of tizanidine in mice and rats
The antinociceptive action of tizanidine [5-chloro-(2-imidazolin-2-yl-amino)-2,1,3-benzothiadiazole], a centrally acting muscle relaxant, was...
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Clinical Experience with Benzodiazepines in Psychosomatic Disorders
Illness in general, of whatever type, is a reaction by the person to a variety of changing events both in the internal and external environments. In...