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Nicotine pharmacokinetics and subjective responses after using nicotine pouches with different nicotine levels compared to combustible cigarettes and moist smokeless tobacco in adult tobacco users
RationaleOral tobacco–derived nicotine products include on!® nicotine pouches (NPs) which are tobacco-leaf free and available in multiple flavors and...
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Electronic cigarettes and cardiovascular disease: epidemiological and biological links
Electronic cigarettes (e-cigarettes), as alternative nicotine delivery methods, has rapidly increased among youth and adults in recent years....
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Evidence of premature vascular dysfunction in young adults who regularly use e-cigarettes and the impact of usage length
BackgroundElectronic (e-) cigarettes are increasingly popular tobacco products on the US market. Traditional tobacco products are known to cause...
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The effect of e-cigarettes on cognitive function: a sco** review
AimMuch research has been conducted on the acute effects of nicotine on human cognitive performance, demonstrating both enhancing and impairing...
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A randomised, open-label, cross-over clinical study to evaluate the pharmacokinetic, pharmacodynamic and safety and tolerability profiles of tobacco-free oral nicotine pouches relative to cigarettes
RationaleTobacco harm reduction (THR) involves encouraging adult smokers who would otherwise continue to smoke to transition to less harmful forms of...
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Biomarkers of Tobacco Use: Relevance to Tobacco Harm Reduction
Cigarette smoking is associated with a large number of adverse health outcomes and continues to be a major contributor to death and disease. Although...
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Estimating the reduction in US mortality if cigarettes were largely replaced by e-cigarettes
BackgroundRecent estimates indicated substantially replacing cigarettes by e-cigarettes would, during 2016–2100, reduce US deaths and life-years lost...
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Multimodal 7T imaging reveals enhanced functional coupling between salience and frontoparietal networks in young adult tobacco cigarette smokers
Tobacco cigarette smoking is associated with disrupted brain network dynamics in resting brain networks including the Salience (SN) and Fronto...
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Electronic cigarettes versus nicotine patches for smoking cessation in pregnancy: a randomized controlled trial
Nicotine replacement therapy, in the form of nicotine patches, is commonly offered to pregnant women who smoke to help them to stop smoking, but this...
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Impact of Smokeless Tobacco on Cardiovascular Disease Risk in a Nigerian Metropolitan City
The use of smokeless tobacco products (STP) as a substitute for tobacco smoking is driving increasing consumption of these products especially in...
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Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention
Tobacco products present a deadly combination of nicotine addiction and carcinogen exposure resulting in millions of cancer deaths per year...
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Regulation of endothelial function by cigarette smoke and next-generation tobacco and nicotine products
Cigarette smoking is the most important avoidable cardiovascular risk factor. It causes endothelial dysfunction and atherosclerosis and increases the...
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Assessments of occupational health hazards of tobacco farmworkers in Andhra Pradesh, India
ObjectiveThe present study aims to find occupational health hazards during agricultural operations performed by tobacco farmworkers and their...
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Assessment of the exposure to polycyclic aromatic hydrocarbons in users of various tobacco/nicotine products by suitable urinary biomarkers
Polycyclic aromatic hydrocarbons (PAHs) occur naturally (bitumen and oils) and are formed during all incomplete combustions of organic materials. PAH...
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Simulation Modeling of Air and Droplet Temperatures in the Human Respiratory Tract for Inhaled Tobacco Products
Respiratory tract dosimetry predictions for inhalation of tobacco product smoke and aerosols are sensitive to the values of the physicochemical...
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Biomarkers of Tobacco Use: Relevance to Tobacco Harm Reduction
Cigarette smoking is associated with a large number of adverse health outcomes and continues to be a major contributor to death and disease. Although...
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Cancer potencies and margin of exposure used for comparative risk assessment of heated tobacco products and electronic cigarettes aerosols with cigarette smoke
Health risk associated with the use of combustible cigarettes is well characterized and numerous epidemiological studies have been published for many...
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Nicotine pharmacokinetics and subjective response among adult smokers using different flavors of on!® nicotine pouches compared to combustible cigarettes
Rationaleon!® nicotine pouches (NPs) are oral tobacco-derived nicotine products that are tobacco-leaf free and are available in a variety of flavors...
