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Unraveling malignant phenotype of peritumoral tissue: transcriptomic insights into early-stage breast cancer
BackgroundEarly-stage invasive ductal carcinoma displays high survival rates due to early detection and treatments. However, there is still a chance...
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Single-nucleus RNA sequencing and deep tissue proteomics reveal distinct tumour microenvironment in stage-I and II cervical cancer
BackgroundCervical cancer (CC) is the 3 rd most common cancer in women and the 4 th leading cause of deaths in gynaecological malignancies, yet the...
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Targeted Metabolomic Analysis of the Eye Tissue of Triple Transgenic Alzheimer’s Disease Mice at an Early Pathological Stage
Alzheimer’s disease (AD) is a severe neurodegenerative disease in older people. Despite some consensus on pathogenesis of AD established by previous...
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Registry-derived stage (RD-Stage) for capturing cancer stage at diagnosis for endometrial cancer
BackgroundCapture of cancer stage at diagnosis is important yet poorly reported by health services to population-based cancer registries. In this...
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Biopolyesters in Tissue Engineering Applications
Tissue engineering is a rapidly growing interdisciplinary field of research focused on the development of vital autologous tissue through the use...
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Development and validation of a Radiopathomics model based on CT scans and whole slide images for discriminating between Stage I-II and Stage III gastric cancer
ObjectiveThis study aimed to develop and validate an artificial intelligence radiopathological model using preoperative CT scans and postoperative...
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Role of Inflammation in Tissue Regeneration and Repair
Inflammation plays critical roles in tissue repair and regeneration. After tissue injury, inflammatory immune cells are recruited to the wound site,...
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Decellularized Tissue-Induced Cellular Recruitment for Tissue Engineering and Regenerative Medicine
Biomaterials that recapitulate the native in vivo microenvironment are promising to facilitate tissue repair and regeneration when used in...
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Modeling a Liver-Stage Malaria
This chapter starts with problems in the use of the disease model in drug discovery and pre-clinical study. Then, it provides information on...
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Tissue-specific macrophages: how they develop and choreograph tissue biology
Macrophages are innate immune cells that form a 3D network in all our tissues, where they phagocytose dying cells and cell debris, immune complexes,...
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Evaluation of the Effectiveness of Bone Grafting in Alveolar Ridge Augmentation Using the Two-Stage Splitting Technique
Stimulation of neoosteogenesis is the main mechanism of osseointegration during installation of dental implants, bone tissue recession, and alveolar...
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Low-dose acetylsalicylic acid reduces local inflammation and tissue perfusion in dense breast tissue in postmenopausal women
PurposeOne major risk factor for breast cancer is high mammographic density. It has been estimated that dense breast tissue contributes to ~ 30% of...
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Myocardial Tissue Repair and Regeneration
Heart failure caused by myocardial infarction (MI) remains a major threat to human health. After MI, a series of pathological events take place,...
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Frozen Block Tissue Staining for Eye Structure of Zebrafish Embryo
Histology is a technique used to study the morphology of cell structures by cutting samples into thin sections. Histological cross-section and...
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Soft Tissue Sarcoma
Soft tissue sarcomas are rare mesenchymal malignancies made up of several heterogeneous subtypes with distinct clinicopathologic features....
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Protein prognostic biomarkers in stage II colorectal cancer: implications for post-operative management
Colorectal cancer (CRC) poses a significant threat to many human lives worldwide and survival following resection is predominantly stage dependent....
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The Application of 4-Hexylresorcinol in Tissue Engineering
This chapter explores the potential applications of 4-hexylresorcinol (4HR) in tissue engineering, focusing on its use in silk fibroin membrane...
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Applications of Automatic Unbiased Stereology to Neural Tissue
Stereology methods are the current best practice for state-of-the-art quantification of stained biostructures in tissue sections. Over the past six...
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Novel genome-wide DNA methylation profiling reveals distinct epigenetic landscape, prognostic model and cellular composition of early-stage lung adenocarcinoma
BackgroundLung adenocarcinoma (LUAD) has been a leading cause of cancer-related mortality worldwide. Early intervention can significantly improve...
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The NR2B-targeted intervention alleviates the neuronal injuries at the sub-acute stage of cerebral ischemia: an exploration of stage-dependent strategy against ischemic insults
Stroke is reported to be the second leading cause of death worldwide, among which ischemic stroke has fourfold greater incidence than intracerebral...
