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Targeting MyD88: Therapeutic mechanisms and potential applications of the specific inhibitor ST2825
BackgroundMyeloid differentiation factor-88 (MyD88) is a crucial adapter protein that coordinates the innate immune response and establishes an...
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Targeting PEG10 as a novel therapeutic approach to overcome CDK4/6 inhibitor resistance in breast cancer
BackgroundBreast cancer is the global leading cancer burden in women and the hormone receptor-positive (HR+) subtype is a major part of breast...
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4-Hexylresorcinol as Histone Deacetylase Inhibitor
This chapter investigates the role of 4-hexylresorcinol (4HR) as a histone deacetylase inhibitor (HDACi) specifically targeting Class I and IIa HDACs...
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The therapeutic effect of a novel GAPDH inhibitor in mouse model of breast cancer and efficacy monitoring by molecular imaging
BackgroundBreast cancer is a serious threat to women’s health with high morbidity and mortality. The development of more effective therapies for the...
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The Rac inhibitor HV-107 as a potential therapeutic for metastatic breast cancer
BackgroundThe significant challenge in treating triple-negative breast cancer (TNBC) lies in its high rate of distant metastasis. To address this,...
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Melatonin: a ferroptosis inhibitor with potential therapeutic efficacy for the post-COVID-19 trajectory of accelerated brain aging and neurodegeneration
The unprecedented pandemic of COVID-19 swept millions of lives in a short period, yet its menace continues among its survivors in the form of...
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The novel CDK9 inhibitor, XPW1, alone and in combination with BRD4 inhibitor JQ1, for the treatment of clear cell renal cell carcinoma
BackgroundClear cell renal cell carcinoma (ccRCC) is a highly lethal malignancy with few therapeutic options. Cyclin‑dependent kinase 9 (CDK9), a...
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Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas
Bruton’s tyrosine kinase (BTK) has emerged as a therapeutic target for B-cell malignancies, which is substantiated by the efficacy of various...
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Therapeutic impact of BET inhibitor BI 894999 treatment: backtranslation from the clinic
BackgroundBET inhibitors have been tested in several clinical trials where, despite encouraging preclinical results, substantial clinical benefit in...
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SGLT2 inhibitor as a potential therapeutic approach in hyperthyroidism-induced cardiopulmonary injury in rats
Hyperthyroidism-induced cardiac disease is an evolving health, economic, and social problem affecting well-being. Sodium-glucose cotransporter...
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Clinical characteristics and therapeutic effects of checkpoint inhibitor-related pneumonitis in patients with non-small cell lung cancer
BackgroundWith the application of immune checkpoint inhibitors (ICIs) in cancer treatment, more and more attention has been paid to checkpoint...
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Therapeutic Phytoconstituents-II
Cancer is among the most frightful disorders worldwide and an issue of major concern. Both developed and develo** countries are facing enormous...
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New Antifungal Drugs: Discovery and Therapeutic Potential
There has been an increase in invasive fungal infections, which are a universal problem due to the longer average lifespan, the number of...
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Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1
Necroptosis is a form of regulated necrosis involved in various pathological diseases. The process of necroptosis is controlled by...
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Therapeutic Targeting of Potassium Channels
Potassium (K+) channels are the largest group of ion channels in mammals. The immediate function of these channels is electrogenic transport of K+...
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AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma
BackgroundCurrently, multiple myeloma (MM) is still an incurable plasma cell malignancy in urgent need of novel therapeutic targets and drugs.
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Novel Caspase-1 inhibitor CZL80 improves neurological function in mice after progressive ischemic stroke within a long therapeutic time-window
Progressive ischemic stroke (PIS) is featured by progressive neurological dysfunction after ischemia. Ischemia-evoked neuroinflammation is implicated...
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CDk Inhibitor for Treatment of Breast Cancer
A complicated interaction of Cyclins and cyclin-dependent kinases (CDKs) drives the mammalian cell cycle and one of the main causes or hallmarks of...
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Hypoxia-induced NOS1 as a therapeutic target in hypercholesterolemia-related colorectal cancer
BackgroundIt is well established that hypercholesterolemia increases the risk of atherosclerosis, especially because it reduces the availability of...
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IκBα kinase inhibitor BAY 11-7082 promotes anti-tumor effect in RAS-driven cancers
BackgroundOncogenic mutations in the RAS gene are associated with uncontrolled cell growth, a hallmark feature contributing to tumorigenesis. While...
