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1. Tetrandrine Alleviates Silica-induced Pulmonary Fibrosis Through PI3K/AKT Pathway: Network Pharmacology Investigation and Experimental Validation

   Tetrandrine (TET) is a bisbenzylisoquinoline alkaloid derived from Stephania tetrandra S. Moor, known for its potential use in attenuating the...

   Ruimin Ma, **aoxi Huang, ... Qiao Ye in Inflammation

   Article 24 January 2024
   

2. A (Traditional Chinese Medicine) TCM-Inspired Doxorubicin Resistance Reversing Strategy: Preparation, Characterization, and Application of a Co-loaded pH-Sensitive Liposome

   In this study, nano-strategy for combined medication of active compounds from traditional Chinese medicine herbs was proposed to achieve the...

   Xueyan Zhang, Hua Liu, ... **aoliang Ren in AAPS PharmSciTech

   Article 11 September 2023
   

3. Tet Enzyme-Mediated Response in Environmental Stress and Stress-Related Psychiatric Diseases

   Mental disorders caused by stress have become a worldwide public health problem. These mental disorders are often the results of a combination of...

   Meiling **a, Rui Yan, ... **ngshun Xu in Molecular Neurobiology

   Article 19 December 2022
   

4. Transcription factor EGR2 controls homing and pathogenicity of T_H17 cells in the central nervous system

   CD4 ⁺ T helper 17 (T _H 17) cells protect barrier tissues but also trigger autoimmunity. The mechanisms behind these opposing processes remain unclear....

   Yuanyuan Gao, Yan Wang, ... Vanja Lazarevic in Nature Immunology

   Article 13 July 2023
   

5. Global DNA Methylation Analysis Using Methylcytosine Dioxygenase

   Because the alteration of global DNA methylation levels is detected in various cancer cells, the global DNA methylation level is expected as a...

   Natsumi Taka, Wataru Yoshida in DNA Modification Detection Methods

   Protocol 2022
   

6. ROS attenuates TET2-dependent ZO-1 epigenetic expression in cerebral vascular endothelial cells

   Aims

   To investigate whether DNA active demethylase TET regulates the expression of tight junction proteins in endothelial cells of the blood–brain...

   Lan Wang, Bei Mao, ... Ying Liu in Fluids and Barriers of the CNS

   Article Open access 08 September 2022
   

7. Quercetin Mediated TET1 Expression Through MicroRNA-17 Induced Cell Apoptosis in Melanoma Cells

   A previous report suggested that the expression of ten-eleven translocation (TET) proteins is abnormal in certain cancers. Quercetin has been...

   Yongjian Gao, Chengshun Li, ... Ye Feng in Biochemical Genetics

   Article 22 September 2022
   

8. Coexistence of tet(A) and bla_KPC-2 in the ST11 hypervirulent tigecycline- and carbapenem-resistant Klebsiella pneumoniae isolated from a blood sample

   Carbapenem-resistant Klebsiella pneumoniae are distributed worldwide. This study aimed to characterize a hypervirulent tigecycline-resistant and...

   **aokui Zhu, Changwu Yue, ... Xu Jia in European Journal of Clinical Microbiology & Infectious Diseases

   Article Open access 02 November 2022
   

9. Early Evidence of Global DNA Methylation and Hydroxymethylation Changes in Rat Kidneys Consequent to Hyperoxaluria-Induced Renal Calcium Oxalate Stones

   Abstract

   Calcium supersaturation in urine during hyperoxaluria can lead to renal calcium oxalate (CaOx) stone deposition; a condition termed as...

   Yogita Mehra, Pragasam Viswanathan in Cytology and Genetics

   Article 20 September 2022
   

10. Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects

    One of the major hurdles that has hindered the success of chimeric antigen receptor (CAR) T cell therapies against solid tumors is on-target...

    Yufei Wang, Alicia Buck, ... Wayne A. Marasco in Molecular Cancer

    Article Open access 16 March 2024
    

11. Gene Augmentation for Autosomal Dominant CRX-Associated Retinopathies

    The cone-rod homeobox (CRX) protein is a key transcription factor essential for photoreceptor function and survival. Mutations in human CRX gene are...

    Chi Sun, Shiming Chen in Retinal Degenerative Diseases XIX

    Conference paper 2023
    

12. The maturation of iPS cell-derived brain microvascular endothelial cells by inducible-SOX18 expression

    Background

    Brain microvascular endothelial cells (BMECs) play a major role in the blood–brain barrier (BBB), and are critical for establishing an in...

    Hongyan Zhang, Tomoko Yamaguchi, Kenji Kawabata in Fluids and Barriers of the CNS

    Article Open access 02 February 2023
    

13. PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development

    Background

    Parathyroid hormone-related protein (PTHrP) is required for embryonic breast development and has important functions during lactation, when...

    Diego Y. Grinman, Kata Boras-Granic, ... John J. Wysolmerski in Breast Cancer Research

    Article Open access 19 April 2022
    

14. A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau

    Background

    Intraneuronal accumulation of hyperphosphorylated tau is a defining hallmark of Alzheimer’s disease (AD). However, mouse models imitating...

    Yang Gao, Yuying Wang, ... Jian-Zhi Wang in Translational Neurodegeneration

    Article Open access 10 November 2023
    

15. New genetic and epigenetic insights into the chemokine system: the latest discoveries aiding progression toward precision medicine

    Over the past thirty years, the importance of chemokines and their seven-transmembrane G protein-coupled receptors (GPCRs) has been increasingly...

    Hanli Xu, Shuye Lin, ... Jiaqiang Huang in Cellular & Molecular Immunology

    Article Open access 17 May 2023
    

16. Immunotherapy of thymic epithelial tumors: molecular understandings and clinical perspectives

    Immunotherapy has emerged to play a rapidly expanding role in the treatment of cancers. Currently, many clinical trials of therapeutic agents are on...

    Yong-Qiang Ao, Jian Gao, ... Jian-Yong Ding in Molecular Cancer

    Article Open access 13 April 2023
    

17. TET2 inhibits the proliferation and metastasis of lung adenocarcinoma cells via activation of the cGAS-STING signalling pathway

    Background

    Effective identification and development of new molecular methods for the diagnosis, treatment and prognosis of lung adenocarcinoma (LUAD)...

    Gui Cheng, Jun Wu, ... **gting Jiang in BMC Cancer

    Article Open access 04 September 2023
    

18. Synergistic cytotoxicity of decitabine and YM155 in leukemia cells through upregulation of SLC35F2 and suppression of MCL1 and survivin expression

    The hypomethylation agent decitabine (DAC), in combination with other apoptosis inducers, is considered a potential modality for cancer treatment. We...

    **g-Ting Chiou, Long-Sen Chang in Apoptosis

    Article 08 December 2023
    

19. FLAG-KRAS4B as a Model System for KRAS4B Proteoform and PTM Evaluation by Mass Spectrometry

    Prior analysis of intact and modified protein forms (proteoforms) of KRAS4B isolated from cell lines and tumor samples by top-down mass spectrometry...

    Robert A. D’Ippolito, Grace M. Scheidemantle, ... Caroline J. DeHart in KRAS

    Protocol 2024
    

20. Tet3 Deletion in Adult Brain Neurons of Female Mice Results in Anxiety-like Behavior and Cognitive Impairments

    TET enzymes (TET1-3) are dioxygenases that oxidize 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and are involved in the DNA...

    Cláudia Antunes, Jorge D. Da Silva, ... C. Joana Marques in Molecular Neurobiology

    Article 03 June 2022