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Glibenclamide Directly Prevents Neuroinflammation by Targeting SUR1-TRPM4-Mediated NLRP3 Inflammasome Activation In Microglia
Glibenclamide (GLB) reduces brain edema and improves neurological outcome in animal experiments and preliminary clinical studies. Recent studies also...
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Pathological activation of CaMKII induces arrhythmogenicity through TRPM4 overactivation
TRPM4 is a Ca 2+ -activated nonselective cation channel involved in cardiovascular physiology and pathophysiology. Based on cellular experiments and...
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Upregulation of transient receptor potential melastatin 4 (TRPM4) in ventricular fibroblasts from heart failure patients
The transient receptor potential melastatin 4 (TRPM4) is a Ca 2+ -activated nonselective monovalent cation channel belonging to the TRP channel...
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Development of an AAV9-RNAi-mediated silencing strategy to abrogate TRPM4 expression in the adult heart
The cation channel transient receptor potential melastatin 4 (TRPM4) is a calcium-activated non-selective cation channel and acts in cardiomyocytes...
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TRPM4 non-selective cation channel in human atrial fibroblast growth
Cardiac fibroblasts play an important role in cardiac matrix turnover and are involved in cardiac fibrosis development. Ca 2+ is a driving belt in...
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Flufenamic acid improves survival and neurologic outcome after successful cardiopulmonary resuscitation in mice
BackgroundBrain injury is the main cause of high mortality and disability after successful cardiopulmonary resuscitation (CPR) from sudden cardiac...
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Glibenclamide for Brain Contusions: Contextualizing a Promising Clinical Trial Design that Leverages an Imaging-Based TBI Endotype
TBI heterogeneity is recognized as a major impediment to successful translation of therapies that could improve morbidity and mortality after injury....
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TRPM4-specific blocking antibody attenuates reperfusion injury in a rat model of stroke
Reperfusion therapy is currently the gold standard treatment for acute ischemic stroke. However, reperfusion injuries such as oedema and haemorrhagic...
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TRPC Channels in Cardiac Arrhythmia: Their Role during Purinergic Activation Induced by Ischemia
Cardiac electrical activity is mainly determined by a set of voltage-dependent channels that control depolarizing currents carried by Na+ and Ca2+...
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Abcc8 (sulfonylurea receptor-1) knockout mice exhibit reduced axonal injury, cytotoxic edema and cognitive dysfunction vs. wild-type in a cecal ligation and puncture model of sepsis
Sepsis-associated brain injury (SABI) is characterized by an acute deterioration of mental status resulting in cognitive impairment and acquisition...
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Increased TRPM4 Activity in Cerebral Artery Myocytes Contributes to Cerebral Blood Flow Reduction After Subarachnoid Hemorrhage in Rats
Cerebral blood flow (CBF) reduction underlies unfavorable outcomes after subarachnoid hemorrhage (SAH). Transient receptor potential melastatin-4...
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Resveratrol Prevents Cell Swelling Through Inhibition of SUR1 Expression in Brain Micro Endothelial Cells Subjected to OGD/Recovery
The SUR1-TRPM4-AQP4 complex is overexpressed in the initial phase of edema induced after cerebral ischemia, allowing the massive internalization of Na
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Shear Stress, Myogenic Response, and Blood Flow Autoregulation
The vascular activity is tonically regulated by two major hemodynamic variations: a force parallel to the blood flow brushing against the endothelial...
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TRP Channels in Stroke
Ischemic stroke is a devastating disease that affects millions of patients worldwide. Unfortunately, there are no effective medications for...
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Alterations in brain fluid physiology during the early stages of development of ischaemic oedema
Oedema occurs when higher than normal amounts of solutes and water accumulate in tissues. In brain parenchymal tissue, vasogenic oedema arises from...
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Involvement of TRPM4 in detrusor overactivity following spinal cord transection in mice
Transient receptor potential cation channel subfamily M member 4 (TRPM4) has been shown to play a key role in detrusor contractility under...
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SLC26A11 Inhibition Reduces Oncotic Neuronal Death and Attenuates Stroke Reperfusion Injury
Neuronal swelling is a pathological feature of stroke which contributes to the formation of cytotoxic edema. Under hypoxic condition, aberrant...
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Correction to: Non-Invasive Multimodality Imaging Directly Shows TRPM4 Inhibition Ameliorates Stroke Reperfusion Injury
The original version of the article unfortunately contained an error.
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PTPN6 regulates the cell-surface expression of TRPM4 channels in HEK293 cells
Transient receptor-potential, cation channel, subfamily M, member 4 (TRPM4) channels regulate a variety of physiological and pathological processes;...
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Ion Channel Dysregulation Following Intracerebral Hemorrhage
Injury to the brain after intracerebral hemorrhage (ICH) results from numerous complex cellular mechanisms. At present, effective therapy for ICH is...
