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TRP Channels in Stroke
Ischemic stroke is a devastating disease that affects millions of patients worldwide. Unfortunately, there are no effective medications for...
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Advances in TRP channel drug discovery: from target validation to clinical studies
Transient receptor potential (TRP) channels are multifunctional signalling molecules with many roles in sensory perception and cellular physiology....
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Dermorphin [D-Arg2, Lys4] (1-4) Amide Alleviates Frostbite-Induced Pain by Regulating TRP Channel-Mediated Microglial Activation and Neuroinflammation
Cold injury or frostbite is a common medical condition that causes serious clinical complications including sensory abnormalities and chronic pain...
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Thermal gradient ring for analysis of temperature-dependent behaviors involving TRP channels in mice
There are a lot of temperature-sensitive proteins including transient receptor potential (TRP) channels. Some TRP channels are temperature receptors...
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The Effects of Carvacrol on Transient Receptor Potential (TRP) Channels in an Animal Model of Parkinson’s Disease
In this study, we aimed to investigate the effects of carvacrol (CA), a widely used phytochemical having anti-oxidant and neuroprotective effects, on...
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TRP Channels, Oxidative Stress, and Cancer
Transient receptor potential (TRP) channels have evolved as trigger for many physiological and pathophysiological conditions including cancer. These...
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Thermal gradient ring reveals different temperature-dependent behaviors in mice lacking thermosensitive TRP channels
Transient receptor potential (TRP) channels are known as temperature receptors. Each channel has an activation temperature in vitro within the...
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TRP channels: a journey towards a molecular understanding of pain
The perception of nociceptive signals, which are translated into pain, plays a fundamental role in the survival of organisms. Because pain is linked...
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Roles of Intramolecular Interactions in the Regulation of TRP Channels
The transient receptor potential (TRP) channels, classified into six (-A, -V, -P, -C, -M, -ML, -N and -Y) subfamilies, are important membrane sensors...
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Epigenetic Connections of the TRPA1 Ion Channel in Pain Transmission and Neurogenic Inflammation — a Therapeutic Perspective in Migraine?
Persistent reprogramming of epigenetic pattern leads to changes in gene expression observed in many neurological disorders. Transient receptor...
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Distribution and Assembly of TRP Ion Channels
In the last several decades, a large family of ion channels have been identified and studied intensively as cellular sensors for diverse physical...
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TRP Channels, Oxidative Stress, and Cancer
Transient receptor potential (TRP) channels have evolved as trigger for many physiological and pathophysiological conditions including cancer. These...
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Isolation of human TRPA1 channel from transfected HEK293 cells and identification of alkylation sites after sulfur mustard exposure
Transient receptor potential (TRP) channels are important in the sensing of pain and other stimuli. They may be triggered by electrophilic agonists...
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Ion Channel Dysregulation Following Intracerebral Hemorrhage
Injury to the brain after intracerebral hemorrhage (ICH) results from numerous complex cellular mechanisms. At present, effective therapy for ICH is...
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Transient Receptor Potential (TRP) Ion Channels in Orofacial Pain
Orofacial pain, including temporomandibular joint disorders pain, trigeminal neuralgia, dental pain, and debilitating headaches, affects millions of...
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NCS-1 protein regulates TRPA1 channel through the PI3K pathway in breast cancer and neuronal cells
The physical and functional interaction between transient receptor potential channel ankyrin 1 (TRPA1) and neuronal calcium sensor 1 (NCS-1) was...
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Ion Channel Tools and Therapeutics from Venoms and Toxins
For almost as long as the ion channels in our brains have powered conscious thought, we have been fascinated by venoms and toxins. Initially thought...
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Effect of Hesperidin on Sciatic Nerve Damage in STZ-Induced Diabetic Neuropathy: Modulation of TRPM2 Channel
Diabetic neuropathy (DNP) is a severe complication of diabetes mellitus. In this study, we examined the potential of hesperidin (HES) to attenuate...
