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Development of a TLR-Based Model That Can Predict Prognosis, Tumor Microenvironment, and Drug Response for Esophageal Squamous Cell Carcinoma
The toll-like receptor (TLR) family is an important class of proteins involved in the immune response. However, little is known about the association...
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Silencing ApoC3 alleviates LPS-induced acute lung injury by inhibiting TLR signaling pathway
This study aims to confirm whether apolipoprotein C3 (ApoC3) can regulate the inflammatory response and tissue damage in acute lung injury (ALI) and...
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B1-cell-produced anti-phosphatidylserine antibodies contribute to lupus nephritis development via TLR-mediated Syk activation
Autoantibodies produced by B cells play a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE). However, both the cellular source...
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Regulation of toll-like receptor (TLR) signaling pathways in atherosclerosis: from mechanisms to targeted therapeutics
Atherosclerosis, one of the life-threatening cardiovascular diseases (CVDs), has been demonstrated to be a chronic inflammatory disease, and...
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Endotoxin tolerance and low activation of TLR-4/NF-κB axis in monocytes of COVID-19 patients
AbstractHigher endotoxin in the circulation may indicate a compromised state of host immune response against coinfections in severe COVID-19...
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The TLR/MyD88 signalling cascade in inflammation and gastric cancer: the immune regulatory network of Helicobacter pylori
Helicobacter pylori -induced chronic gastritis represents a well-established risk factor for gastric cancer (GC). However, the mechanism by which...
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Use of CRISPR/CAS9 Technologies to Study the Role of TLR in Dendritic Cell Subsets
Dendritic cells (DCs) have a significant role in coordinating both innate and adaptive immunity by serving as sentinels that detect invaders and...
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Placental TLR recognition of salivary and subgingival microbiota is associated with pregnancy complications
BackgroundPre-term birth, the leading cause of neonatal mortality, has been associated with maternal periodontal disease and the presence of oral...
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Ubiquitin ligase enzymes and de-ubiquitinating enzymes regulate innate immunity in the TLR, NLR, RLR, and cGAS-STING pathways
Ubiquitination (or ubiquitylation) and de-ubiquitination, which are both post-translational modifications (PTMs) of proteins, have become a research...
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Atorvastatin-induced tolerogenic dendritic cells improve cardiac remodeling by suppressing TLR-4/NF-κB activation after myocardial infarction
ObjectiveMyocardial infarction (MI) caused by ischemic cardiomyocyte necrosis induces inflammatory responses that strongly affect ventricular...
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SNP Analysis of TLR4 Promoter and Its Transcriptional Factor Binding Profile in Relevance to Bovine Subclinical Mastitis
Bovine mastitis is a complex infectious disease that develops in the mammary gland, predominantly caused by a bacterial infection of mammary tissue....
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Deciphering the TLR transcriptome and downstream signaling pathway in cerebrospinal fluid in pediatric meningitis
Objective/designPediatric meningitis is characterized by a colossal inflammatory response to the pathogen in the central nervous system (CNS). This...
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Analysis of Differential TLR Activation in a Mouse Model of Multiple Sclerosis
Multiple sclerosis (MS) is a neurodegenerative and autoimmune disease affecting the central nervous system (CNS). The precise etiology of MS is still...
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Ascorbic acid along with ciprofloxacin regulates S. aureus induced microglial inflammatory responses and oxidative stress through TLR-2 and glucocorticoid receptor modulation
Microglial inflammatory responses play a central role in the pathogenesis of S. aureus induced brain infections. Upon activation, microglia produces...
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TLR Signaling in Brain Immunity
Toll-like receptors (TLRs) comprise a group of transmembrane proteins with crucial roles in pathogen recognition, immune responses, and signal...
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Polyene Phosphatidylcholine Interacting with TLR-2 Prevents the Synovial Inflammation via Inactivation of MAPK and NF-κB Pathways
Rheumatoid arthritis (RA) is a chronic autoimmune joint disease that causes cartilage and bone damage or even disability, seriously endangering human...
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Molecular mechanism of empagliflozin cardioprotection in 5-fluorouracil (5-FU)-induced cardiotoxicity via modulation of SGLT2 and TNFα/TLR/NF-κB signaling pathway in rats
One of the commoly used chemotherapeutic agents is 5-Fluorouracil (5-FU). Unfortunately, the clinical administration of 5-FU is complicated with...
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Dose-Dependent Cardioprotective Effect of Hemin in Doxorubicin-Induced Cardiotoxicity Via Nrf-2/HO-1 and TLR-5/NF-κB/TNF-α Signaling Pathways
Doxorubicin (DOX) is one of the most widely used chemotherapeutic drugs, but its cardiotoxicity has been shown to be a dose-restricting factor during...
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The Role of Toll-Like Receptor (TLR) Polymorphisms in Urinary Bladder Cancer
Urinary bladder cancer (BCa), a high ranked and common cancer around the world is a great concern for the global public health systems. Although our...
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Evaluation of E. coli Nissle1917 derived metabolites in modulating key mediator genes of the TLR signaling pathway
ObjectiveGut-microbiota plays key roles in many aspects like the health and illness of humans. It's well proved that modification of gut microbiota...
