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Angiogenic cytokines can reflect the synovitis severity and treatment response to biologics in rheumatoid arthritis
Angiogenesis and synoviocyte hyperplasia, called ‘pannus,’ are pathologic hallmarks of rheumatoid arthritis (RA). To determine the clinical...
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Blocking prokineticin receptors attenuates synovitis and joint destruction in collagen-induced arthritis
AbstractRheumatoid arthritis (RA) is a chronic inflammatory disease mediated by an interdependent network of proinflammatory molecules such as...
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Assessment of Musculoskeletal Ultrasound of Rheumatoid Arthritis
Musculoskeletal ultrasound (MSUS) is a valuable tool that is used in outpatient clinics or at the bedside to assess multiple joint sites, including...
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Botulinum Toxin Therapy in Veterinary Medicine
Emerging literature supports that local injection of botulinum toxins can help local pain in animals. In dogs, botulinum toxin injections have been...
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Genistein promotes cartilage repair and inhibits synovial inflammatory response after anterior cruciate ligament transection in rats by regulating the Wnt/β-catenin axis
To confirm the protective mechanism of genistein on osteoarthritis (OA). Firstly, we constructed an anterior cruciate ligament transection (ACLT) rat...
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Modulation of αVβ6 integrin in osteoarthritis-related synovitis and the interaction with VTN(381–397 a.a.) competing for TGF-β1 activation
Osteoarthritis is characterized by structural alteration of joints. Fibrosis of the synovial tissue is often detected and considered one of the main...
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The emerging role of the semaphorin family in cartilage and osteoarthritis
In the pathogenesis of osteoarthritis, various signaling pathways may influence the bone joint through a common terminal pathway, thereby...
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Comprehensive analysis of arachidonic acid metabolism-related genes in diagnosis and synovial immune in osteoarthritis: based on bulk and single-cell RNA sequencing data
BackgroundOsteoarthritis (OA) is one of degenerative-related arthritis, which can be aggravated by low-grade synovitis. It is known that arachidonic...
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Targeting macrophagic PIM-1 alleviates osteoarthritis by inhibiting NLRP3 inflammasome activation via suppressing mitochondrial ROS/Cl− efflux signaling pathway
BackgroundOsteoarthritis (OA), in which macrophage-driven synovitis is considered closely related to cartilage destruction and could occur at any...
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Anti-inflammatory and Antioxidant Effect of Poly-gallic Acid (PGAL) in an In Vitro Model of Synovitis Induced by Monosodium Urate Crystals
Gout is a chronic and degenerative disease that affects the joints and soft tissues because of the crystalline deposit of monosodium urate. The...
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Botulinum Toxin Treatment for Pain Indications in Veterinary Medicine
In dogs, botulinum toxin injections have been studied in painful osteoarthritis and pain after mastectomy for malignant breast cancer. In horses,...
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Expression pattern analysis of m6A regulators reveals IGF2BP3 as a key modulator in osteoarthritis synovial macrophages
BackgroundDisruption of N6 methyl adenosine (m6A) modulation hampers gene expression and cellular functions, leading to various illnesses. However,...
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Bispecific T cell engager therapy for refractory rheumatoid arthritis
Bispecific T cell engagers (BiTEs) kill B cells by engaging T cells. BiTEs are highly effective in acute lymphoblastic leukemia. Here we treated six...
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Ångstrom-scale silver particles ameliorate collagen-induced and K/BxN-transfer arthritis in mice via the suppression of inflammation and osteoclastogenesis
ObjectiveNanoparticles (NPs) hold a great promise in combating rheumatoid arthritis, but are often compromised by their toxicities because the...
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Lipidome profile predictive of disease evolution and activity in rheumatoid arthritis
Lipid mediators are crucial for the pathogenesis of rheumatoid arthritis (RA); however, global analyses have not been undertaken to systematically...
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Indole-3-propionic acid alleviates chondrocytes inflammation and osteoarthritis via the AhR/NF-κB axis
BackgroundOsteoarthritis (OA) is a common chronic disease characterized by chronic inflammation and extracellular matrix degradation....
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Inflammatory Bowel Disease and Rheumatoid Arthritis
Chapter 7 mentioned that there is a deep relationship between inflammation and cancer, which are regulated by...
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Detection of vector-borne pathogens in owned dogs with cranial cruciate ligament rupture living in the Mediterranean area
BackgroundCranial cruciate ligament rupture (CCLR) results from a multifactorial degenerative process that leads to rupture of the ligament....
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Inhibition of pSTAT1 by tofacitinib accounts for the early improvement of experimental chronic synovitis
BackgroundIn order to gain insight into the early effects drawn by JAK inhibitors on intra-joint JAK/STAT-dependent signaling, we sought synovial...
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Identification of ferroptosis related markers by integrated bioinformatics analysis and In vitro model experiments in rheumatoid arthritis
BackgroundRheumatoid arthritis (RA) is an autoimmune disease characterized by destructive and symmetrical joint diseases and synovitis. This research...
