Search
Search Results
-
Molecular Mechanisms Underlying Synaptic Tagging and Consolidation
After a synapse undergoes long-term potentiation (LTP), it acquires a newly remodeled molecular and structural organization. This reorganization over...
-
Synaptic Tagging and Capture: Functional Implications and Molecular Mechanisms
This chapter introduces the concept of synaptic tagging and capture, which was first identified in electrophysiological studies in hippocampal brain...
-
Synaptic Tagging in the ACC: Basic Mechanisms and Functional Implications
Synaptic tagging and capture (STC) is believed to play important roles in hippocampus-related associative memory. Recent studies in the anterior...
-
Synaptic Tagging and Capture From Synapses to Behavior
This reference presents a detailed exploration of the synaptic tagging and capture model, which has been proposed to provide a conceptual basis for...
-
Synaptic mechanisms underlying onset and progression of memory deficits caused by hippocampal and midbrain synucleinopathy
Cognitive deficits, including working memory, and visuospatial deficits are common and debilitating in Parkinson’s disease. α-synucleinopathy in the...
-
Early Life Stress and Major Depressive Disorder—An Update on Molecular Mechanisms and Synaptic Impairments
Early life stress (ELS), characterized as abuse, neglect, and abandonment, can cause several adverse consequences in the lives of affected...
-
Mechanisms and Functions of Activity-Regulated Cytoskeleton-Associated Protein in Synaptic Plasticity
Activity-regulated cytoskeleton-associated protein (Arc) is one of the most important regulators of cognitive functions in the brain regions. As a...
-
Synaptic Mechanisms of Delay Eyeblink Classical Conditioning: AMPAR Trafficking and Gene Regulation in an In Vitro Model
An in vitro model of delay eyeblink classical conditioning was developed to investigate synaptic plasticity mechanisms underlying acquisition of...
-
Compartmentalization of Synaptic Tagging and Capture
Testing of the synaptic tagging and capture (STC) hypothesis has produced remarkable work on the understanding of how a single neuron undergoes...
-
Synaptic Tagging and Metaplasticity as Mediators of Neuronal Consciousness
Forming memories for highly arousing, novel, or salient events engages synaptic mechanisms that allow the association of temporally remote events and...
-
Activity-Dependent Protein Transport as a Synaptic Tag
The “synaptic tagging and capture” hypothesis proposes that a hypothetical, cell biological mark is activated in the synapses undergoing early-phase...
-
Synaptic Integration at Neuron-OPC Synapses
The synapses between neurons and oligodendrocyte precursor cells (OPCs) in the central nervous system (CNS) have similar ultrastructures as...
-
Morphological and transcriptomic analyses of stem cell-derived cortical neurons reveal mechanisms underlying synaptic dysfunction in schizophrenia
BackgroundPostmortem studies in schizophrenia consistently show reduced dendritic spines in the cerebral cortex but the mechanistic underpinnings of...
-
Metaplasticity and Synaptic Tag and Capture: Differential Dynamics of Plasticity Regulation in the Hippocampus
Synaptic plasticity is a critical underlying mechanism of learning and memory. There is extensive evidence that neural activity at one point in time...
-
Excitation–transcription coupling, neuronal gene expression and synaptic plasticity
Excitation–transcription coupling (E–TC) links synaptic and cellular activity to nuclear gene transcription. It is generally accepted that E–TC makes...
-
From Where? Synaptic Tagging Allows the Nucleus Not to Care
Most of us now accept that the formation of long-lasting memories requires the de novo transcription of plasticity-related proteins. It is also...
-
Positron Emission Tomography Imaging of Synaptic Dysfunction in Parkinson’s Disease
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases with a complex pathogenesis. Aggregations formed by abnormal deposition...
-
Molecular Mechanisms of Neurotransmitter Release
Neurons communicate with each other by releasing neurotransmitters. This book provides comprehensive coverage of the molecular mechanisms involved in...
-
Sustained Depolarization Induces Gene Expression Pattern Changes Related to Synaptic Plasticity in a Human Cholinergic Cellular Model
Neuronal gene expression in the brain dynamically responds to synaptic activity. The interplay among synaptic activity, gene expression, and synaptic...
-
Purkinje Neurons: Synaptic Plasticy
After three decades of research, it is now well established that molecular mechanisms underlying cerebellar motor learning lead to activity-dependent...