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Survivin degradation by bergenin overcomes pemetrexed resistance
PurposeChemoresistance is a primary factor for treatment failure and tumor recurrence in non-small cell lung cancer (NSCLC) patients. The oncoprotein...
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Synergistic cytotoxicity of decitabine and YM155 in leukemia cells through upregulation of SLC35F2 and suppression of MCL1 and survivin expression
The hypomethylation agent decitabine (DAC), in combination with other apoptosis inducers, is considered a potential modality for cancer treatment. We...
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Selinexor versus doxorubicin in dedifferentiated liposarcoma PDXs: evidence of greater activity and apoptotic response dependent on p53 nuclear accumulation and survivin down‐regulation
BackgroundDedifferentiated liposarcoma (DDLPS), a tumor that lacks effective treatment strategies and is associated with poor outcomes, expresses...
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Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA
BackgroundN 4 -acetylcytidine (ac 4 C) as a significant RNA modification has been reported to maintain the stability of mRNA and to regulate the...
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Promotion of ubiquitination-dependent survivin destruction contributes to xanthohumol-mediated tumor suppression and overcomes radioresistance in human oral squamous cell carcinoma
BackgroundOverexpression of survivin plays a crucial role in tumorigenesis and correlates with poor prognosis in human malignancies. Thus, survivin...
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Unraveling the epigenetic landscape of pulmonary arterial hypertension: implications for personalized medicine development
Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the remodeling of pulmonary blood vessels. If left unaddressed, PAH...
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Epigenetic effects of herbal medicine
Epigenetic memory is essential for life that governs the predefined functional features of cells. Recent evidence has indicated that the epigenetic...
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HDAC6: A unique HDAC family member as a cancer target
BackgroundHDAC6, a structurally and functionally distinct member of the HDAC family, is an integral part of multiple cellular functions such as cell...
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Valproic acid inhibits cell growth in both MCF-7 and MDA-MB231 cells by triggering different responses in a cell type-specific manner
BackgroundBreast cancer is the second leading cause of death among women after lung cancer. Despite the improvement in prevention and in therapy,...
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Mechanistic insights into the dual role of CCAR2/DBC1 in cancer
Cell cycle and apoptosis regulator 2 (CCAR2), also known as deleted in breast cancer 1 (DBC1), has been recently identified as a master regulator of...
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Posttranslational modification and beyond: interplay between histone deacetylase 6 and heat-shock protein 90
Posttranslational modification (PTM) and regulation of protein stability are crucial to various biological processes. Histone deacetylase 6 (HDAC6),...
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Epigenetics as a versatile regulator of fibrosis
Fibrosis, a process caused by excessive deposition of extracellular matrix (ECM), is a common cause and outcome of organ failure and even death....
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Apoptotic and antimetastatic effect of cucurbitacins in cancer: recent trends and advancement
The Cucurbitaceae family produces a class of secondary metabolites known as cucurbitacins. The eight cucurbitacin subunits are cucurbitacin B, D, E,...
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The modulation of PD-L1 induced by the oncogenic HBXIP for breast cancer growth
Programmed death ligand-1 (PD-L1)/PD-1 checkpoint extensively serves as a central mediator of immunosuppression. A tumor-promoting role for abundant...
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Sirtuin insights: bridging the gap between cellular processes and therapeutic applications
The greatest challenges that organisms face today are effective responses or detection of life-threatening environmental changes due to an obvious...
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DDIAS, DNA damage-induced apoptosis suppressor, is a potential therapeutic target in cancer
Increasing evidence indicates that DNA damage-induced apoptosis suppressor (DDIAS) is an oncogenic protein that is highly expressed in a variety of...
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Singlet Anticancer Therapy Through Epi-Weapons Histone Deacetylase Inhibitors and Its Shortcomings
Appalling toxicities and chemoresistance associated with conventional anticancer therapies raise applicability related concerns (Howard et al. 2016)....
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Molecular Biomarkers of Cancer and Their Diagnostic Applications
Cancer, characterized by abnormal cell growth, remains a significant global health concern. The intricate interplay of genetic, epigenetic, and...
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The Role of Interleukin (IL)-6/IL-6 Receptor Axis in Cancer
As a pleiotropic cytokine, interleukin (IL)-6 plays a key role in mediating the host’s immune defense. Multiple cell types are involved in IL-6...
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Phytochemicals in ROS-Mediated Epigenetic Modulation of Cancer
It is a fundamental understanding in molecular biology that changes in DNA are reflected in transcription of aberrant messenger RNA (mRNA) and...