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Randomized controlled phase III trial to investigate superiority of robot-assisted gastrectomy over laparoscopic gastrectomy for clinical stage T1-4aN0-3 gastric cancer patients (JCOG1907, MONA LISA study): a study protocol
BackgroundLaparoscopic gastrectomy (LG) is considered a standard treatment for clinical stage I gastric cancer. Nevertheless, LG has some drawbacks,...
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STRavinsky STR database and PGTailor PGT tool demonstrate superiority of CHM13-T2T over hg38 and hg19 for STR-based applications
Short-Tandem-Repeats (STRs) have long been studied for possible roles in biological phenomena, and are utilized in multiple applications such as...
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Glioma 2021 WHO Classification: The Superiority of NGS Over IHC in Routine Diagnostics
IntroductionThe accurate detection of genetic variants such as single substitutions ( IDH1/2 , TERT ), chromosomal abnormalities ( CDKN2A , 1p/19q...
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Superiority of a Representative MRI Flow Waveform over Doppler Ultrasound for Aortic Wave Reflection Assessment in Children and Adolescents With/Without a History of Heart Disease
Wave separation analysis (WSA) reveals the impact of forward- and backward-running waves on the arterial pressure pulse, but the calculations require...
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RETRACTED ARTICLE: Mechanisms Involved in Superiority of Angiotensin Receptor Blockade over ACE Inhibition in Attenuating Neuropathic Pain Induced in Rats
Although previous reports described the beneficial role of angiotensin-converting enzyme inhibitors (ACE-Is) or AT1 receptor blockers (ARBs) in...
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Biomechanical superiority of locking plate designed with cluster of head screws compared to conventional buttress plate for fixation of posteromedial tibial plateau fractures: A computational assessment
PurposeDealing with high-energy fractures of the tibial plateau remains a challenge despite advances in implants, surgical approaches, and imaging...
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Non-inferiority Clinical Trials
Obviously, if we have preliminary evidence that the new treatment has greater efficacy than what is already available, a traditional superiority...
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Interpreting the results of noninferiority trials—a review
Noninferiority trials are becoming increasing common, but are often poorly reported and misunderstood. A better understanding of the new components...
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Hypofractionated stereotactic radiotherapy (HFSRT) versus single fraction stereotactic radiosurgery (SRS) to the resection cavity of brain metastases after surgical resection (SATURNUS): study protocol for a randomized phase III trial
BackgroundThe brain is a common site for cancer metastases. In case of large and/or symptomatic brain metastases, neurosurgical resection is...
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Preliminary insights into patient preparedness for knee or hip arthroplasty: a descriptive survey study
ObjectiveKnowledge-based preparedness for surgery is achieved through education. It is unclear which of brief or extended education programs prior to...
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Original SARS-CoV-2 monovalent and Omicron BA.4/BA.5 bivalent COVID-19 mRNA vaccines: phase 2/3 trial interim results
This ongoing, open-label, phase 2/3 trial compared the safety and immunogenicity of the Omicron BA.4/BA.5-containing bivalent mRNA-1273.222 vaccine...
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Feature-weight based measurement of cancerous transcriptome using cohort-wide and sample-specific information
Identifying cancerous samples or cells using transcriptomic data is critical for cancer related basic research, early diagnosis, and targeted...
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Stereotactic body radiotherapy versus conventional radiotherapy for painful bone metastases: a systematic review and meta-analysis of randomised controlled trials
BackgroundStereotactic body radiotherapy (SBRT) is a promising approach in treating painful bone metastases. However, the superiority of SBRT over...
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Finotonlimab with chemotherapy in recurrent or metastatic head and neck cancer: a randomized phase 3 trial
Immunotherapy combined with chemotherapy regimen has been shown to be effective in recurrent or metastatic (R/M) head and neck squamous cell...
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Frequency-dependent effective connections between local signals and the global brain signal during resting-state
The psychological and physiological meanings of resting-state global brain signal (GS) and GS topography have been well confirmed. However, the...
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Efficient genomics-based ‘end-to-end’ selective tree breeding framework
Since their initiation in the 1950s, worldwide selective tree breeding programs followed the recurrent selection scheme of repeated cycles of...
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Ending Clinical Trials Prematurely
Clinical trials can be terminated early for one of three reasons: there is a preponderance of adverse events in one arm, or both arms have more than...
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Multi-vendor evaluation of artificial intelligence as an independent reader for double reading in breast cancer screening on 275,900 mammograms
BackgroundDouble reading (DR) in screening mammography increases cancer detection and lowers recall rates, but has sustainability challenges due to...
