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Cell-Based Therapies in Clinical Pain Management
Development of novel therapies is required to transform care for chronic and refractory pain due to degenerative and neuropathic conditions....
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Advances and challenges of the cell-based therapies among diabetic patients
Diabetes mellitus is a significant global public health challenge, with a rising prevalence and associated morbidity and mortality. Cell therapy has...
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The Significance of Biomaterials in Stem Cell-Based Regenerative Medicine
Introduction: Stem cell-based therapeutic strategies have shown tremendous potential in attenuating tissue damage and facilitating tissue repair and...
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A review of current status of cell-based therapies for aortic aneurysms
An aortic aneurysm (AA) is defined as focal aortic dilation that occurs mainly with older age and with chronic inflammation associated with...
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Stem Cell-Based Therapies for Hair Loss: What is the Evidence from a Clinical Perspective?
Introduction: Stem cell-based therapies, especially those based on stem cell-derived conditioned medium (CM) are being widely explored in the...
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Nanotechnology-Driven Cell-Based Therapies in Regenerative Medicine
The administration of cells as therapeutic agents has emerged as a novel approach to complement the use of small molecule drugs and other biologics...
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Next-Generation Cell-Based Therapies to Combat Metastatic Brain Tumor
Glioblastoma (GBM) is a grade IV aggressive type brain tumor that causes rapid proliferation and growth rate. The average survival period is 14 to...
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Cancer Stem Cells: Current Challenges and Future Perspectives
Despite major advances in health care including improved diagnostic tools, robust chemotherapeutic regimens, advent of precision, adjuvant and...
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CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection
Nonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HIV) infections and...
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Eradicating the tumor “seeds”: nanomedicines-based therapies against cancer stem cells
ObjectivesCancer stem cells (CSCs), a small subpopulation of cells with high tumorigenesis and strong intrinsic drug resistance, exhibit self-renewal...
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Delivery strategies for cell-based therapies in the brain: overcoming multiple barriers
Cell-based therapies to the brain are promising for the treatment of multiple brain disorders including neurodegeneration and cancers. In order to...
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Neural Stem Cell Intervention in Traumatic Brain Injury
Introduction: Traumatic brain injury (TBI)Traumatic Brain Injury (TBI) is a major cause of death and disability worldwide. The secondary brain damage...
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Cancer Stem Cells
Cancer stem cells (CSCs) share traits with healthy stem or precursor cells, which include having the capacity to self-renew and differentiate into...
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A new era of macrophage-based cell therapy
Macrophages are essential innate immune cells found throughout the body that have protective and pathogenic functions in many diseases. When...
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T-Cell Based Therapies: Clinical Applications and Challenges
The interaction of immune effector cells and cancer is a critical determinant of the therapeutic outcomes in patients influenced by variables related...
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Stem cell-based therapy for COVID-19 and ARDS: a systematic review
Despite global efforts to establish effective interventions for coronavirus disease 2019 (COVID-19) and its major complications, such as acute...
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Long-term benefits of hematopoietic stem cell-based macrophage/microglia delivery of GDNF to the CNS in a mouse model of Parkinson’s disease
Glial cell line-derived neurotrophic factor (GDNF) protects dopaminergic neurons in various models of Parkinson’s disease (PD). Cell-based GDNF gene...
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Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear
Hearing loss has become increasingly prevalent and causes considerable disability, thus gravely burdening the global economy. Irreversible loss of...
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Cell therapy for Parkinson’s disease with induced pluripotent stem cells
Parkinson’s disease (PD) is the second most common neurodegenerative disease and a prime target of cell therapies. In fact, aborted fetal tissue has...
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Mesenchymal stem cells as therapeutic vehicles for glioma
Glioma is a disease with a poor prognosis despite the availability of multimodality treatments, and the development of novel therapies is urgently...
