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Screening and Clinical Verification of Extracellular Vesicle Biomarkers
Extracellular vesicles (EVs), lipid bilayer-encapsulated membrane particles carrying proteins, lipids, nucleic acids, and sugars, are shed by most...
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High-Throughput Screening to Identify Modulators of Sarcospan
High-throughput screening enables the discovery of disease-modifying small molecules. Here, we describe the development of a scalable, cell-based...
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Virtual Screening Process: A Guide in Modern Drug Designing
Due to its capacity to drastically cut the cost and time necessary for experimental screening of compounds, virtual screening (VS) has grown to be a...
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AI-Driven Enhancements in Drug Screening and Optimization
The greatest challenge in drug discovery remains the high rate of attrition across the different phases of the process, which cost the industry...
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Molecular Dynamics as a Tool for Virtual Ligand Screening
Rational drug design is essential for new drugs to emerge, especially when the structure of a target protein or nucleic acid is known. To that...
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Virtual screening of pyrazole derivatives of usnic acid as new class of anti-hyperglycemic agents against PPARγ agonists
The finest sources of therapeutic agents are natural products, and usnic acid is a secondary metabolite derived from lichen that has a wide range of...
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Screening of small molecule compounds targeting hnRNPA2 protein
Heterogeneous nuclear ribonucleoprotein A2, as an RNA binding protein, participates in the processing and metabolism of RNA molecules. HnRNPA2 is...
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Luminescence-Based Techniques for KRAS Thermal Stability Monitoring
Various biochemical methods have been introduced to detect and characterize KRAS activity and interactions, from which the vast majority is based on...
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Exploring the viral protease inhibitor space driven by consensus scoring-based virtual screening
Dengue fever presents a major health concern, and the lack of an effective vaccine or definite therapeutic regimen has led the research community to...
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A Rapid 3-Day Excipient Screening Methodology and its Application in Identifying Chemical Stabilizers for Solid Formulations with Mixed Mechanisms of Degradation
This study outlines a practical approach for assessing chemical instability by heating the drug-excipient binary mixtures or multi-excipient...
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Monoclonal Antibody Generation Using Single B Cell Screening for Treating Infectious Diseases
The screening of antigen-specific B cells has been pivotal for biotherapeutic development for over four decades. Conventional antibody discovery...
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Exhaled VOC detection in lung cancer screening: a comprehensive meta-analysis
BackgroundLung cancer (LC), characterized by high incidence and mortality rates, presents a significant challenge in oncology. Despite advancements...
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Fluorescence-Based Peptidolytic Assay for High-Throughput Screening of MMP14 Inhibitors
The membrane-bound matrix metalloproteinase 14 (MMP14, also known as MT1-MMP) plays important roles in the remodeling of the extracellular matrix...
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IGF2BP2 promotes lncRNA DANCR stability mediated glycolysis and affects the progression of FLT3-ITD + acute myeloid leukemia
Internal tandem duplication (ITD) is the most common type of FLT3 mutation (FLT3-ITD), accounting for about 25% of AML patients. The expression of...
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CRISPR-Cas and CRISPR-based screening system for precise gene editing and targeted cancer therapy
Target cancer therapy has been developed for clinical cancer treatment based on the discovery of CRISPR (clustered regularly interspaced short...
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Isolation and screening of antimicrobial biosurfactants obtained from mangrove plant root–associated bacteria
The unique properties of biosurfactants obtained from microbes, including their activity at extreme temperatures, make them more attractive than...
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Rapid discovery of high-affinity antibodies via massively parallel sequencing, ribosome display and affinity screening
Develo** therapeutic antibodies is laborious and costly. Here we report a method for antibody discovery that leverages the Illumina HiSeq platform...
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Barriers and facilitators to effective cervical cancer screening in Belize: a qualitative analysis
PurposeBelize has among the highest cervical cancer incidence and mortality rates of Latin American and Caribbean countries. This study evaluates the...
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Mitigating Drug Stability Challenges Through Cocrystallization
Drug stability plays a significant role in the pharmaceutical industry from early-phase drug discovery to product registration as well as the entire...
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A Dual-Readout High-Throughput Screening Assay for Small Molecules Active Against Aspergillus Fumigatus
Human fungal infections caused by molds have been on the rise in recent years. These infections have high mortality rates compared to other fungal...