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Luminescence-Based Techniques for KRAS Thermal Stability Monitoring
Various biochemical methods have been introduced to detect and characterize KRAS activity and interactions, from which the vast majority is based on...
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Stability and Characterization of Protein- and Nucleotide-Based Therapeutics
Throughout the development process of protein or nucleotide-based therapeutics, a broad array of analytical techniques is applied on a routine basis...
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Role of Charge Heterogeneity on Physical Stability of Monoclonal Antibody Biotherapeutic Products
PurposeChemical modifications in monoclonal antibodies can change hydrophobicity, charge heterogeneity as well as conformation, which eventually can...
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Mitigating Drug Stability Challenges Through Cocrystallization
Drug stability plays a significant role in the pharmaceutical industry from early-phase drug discovery to product registration as well as the entire...
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Science- and Risk-Based Stability Strategies to Support Product Lifecycle Changes
ICH Q12 asserts that science- and risk-based approaches are applicable to stability studies supporting Chemistry, Manufacturing and Controls (CMC)...
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The deubiquitinating enzyme USP4 regulates BRCA1 stability and function
BRCA1 plays a suppressive role in breast tumorigenesis. Ubiquitin-dependent degradation is a common mechanism that regulates BRCA1 protein stability,...
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Stability of ascorbic acid in human aqueous humor
ObjectiveThe stability of ascorbic acid (AA) in the human aqueous humor (AqH) remains unclear. This study aimed to investigate the stability of AqH...
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Development, Comparison, and Qualification of Predictive Pharmaceutical Stability Models Using Independent Statistical Tools
PurposeThe predictive modeling approach to assess long-term stability performance of pharmaceuticals by using short-term accelerated stability is of...
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Stability of Protein Pharmaceuticals: Recent Advances
There have been significant advances in the formulation and stabilization of proteins in the liquid state over the past years since our previous...
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Considerations related to the in-use stability of sterile pharmaceutical dosage forms
BackgroundIt is essential to ensure the in-use stability of sterile preparations because they may be vulnerable to microbial contamination during the...
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Developmental Noise and Stability
Development is a very complex and robust process. In this chapter, we have discussed the concept of developmental noise as well as the mechanism of...
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Physicochemical Stability of Space Medicines
Astronauts’ health and wellness maintenance in a unique, isolated, and extreme environment of space is a primary goal for a successful space mission....
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Stability of Polymeric Micelles and Their Regulatory Status
Polymeric micelles (PMs) is an innovation approach toward advancement of nanodrug delivery systems. These PMs overcome the issues related to...
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Controlling flat-foot limit cycle walkers with compliant joints based on local stability variation
This study investigates local stability of a four-link limit cycle walking biped with flat feet and compliant ankle joints. Local stability...
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Lutein Loaded in β-Cyclodextrin Metal-Organic Frameworks for Stability and Solubility Enhancements
Lutein (Lut) is a recognized nutritional supplement known for its antioxidative and anti-inflammatory properties, crucial in mitigating ocular...
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Accelerated Predictive Stability Study of a Pediatric Drug Product for a Supplemental New Drug Application
In this paper, we report two Accelerated Stability Assessment Program (ASAP) studies for a pediatric drug product. Whereas the first study using a...
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Assessing and Engineering Antibody Stability Using Experimental and Computational Methods
Engineering increased stability into antibodies can improve their developability. While a range of properties need to be optimized, thermal stability...
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Dual roles of UFMylation on stalling fork stability
The mechanism governing the stabilization of the replication fork under replication stress is pivotal for maintaining genomic integrity and cellular...
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MBD1 protects replication fork stability by recruiting PARP1 and controlling transcription-replication conflicts
The replication-stress response is essential to ensure the faithful transmission of genetic information to daughter cells. Although several...
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Higher synchronization stability with piano experience: relationship with finger and presentation modality
BackgroundSynchronous finger tap** to external sensory stimuli is more stable for audiovisual combined stimuli than sole auditory or visual...
