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Influence of a Decrease in Blood Viscosity on Arterial Pressure in Normotensive and Spontaneously Hypertensive Rats
We investigated the effect of a decrease in blood viscosity on the mean BP during isovolumic hemodilution and vasodilating activity of the...
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Hemodynamic Parameters in Spontaneously Hypertensive Rats with Obesity and Chemically Induced Colitis during Probiotic Therapy
We studied the dynamics of the main hemodynamic parameters in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats with visceral obesity...
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Exercise-induced cardiac mitochondrial reorganization and enhancement in spontaneously hypertensive rats
The myocardium is a highly oxidative tissue in which mitochondria are essential to supply the energy required to maintain pump function. When...
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Microbiota-derived acetate attenuates neuroinflammation in rostral ventrolateral medulla of spontaneously hypertensive rats
BackgroundIncreased neuroinflammation in brain regions regulating sympathetic nerves is associated with hypertension. Emerging evidence from both...
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Differential Effects of Neonatal Ventral Hippocampus Lesion on Behavior and Corticolimbic Plasticity in Wistar–Kyoto and Spontaneously Hypertensive Rats
Dysfunction of the corticolimbic system, particularly at the dendritic spine level, is a recognized core mechanism in neurodevelopmental disorders...
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Effects of Chronic Hypertension on the Energy Metabolism of Cerebral Cortex Mitochondria in Normotensive and in Spontaneously Hypertensive Rats During Aging
In this study the subcellular modifications undergone by cerebral cortex mitochondrial metabolism in chronic hypertension during aging were...
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Sex- and age-related differences in renal and cardiac injury and senescence in stroke-prone spontaneously hypertensive rats
BackgroundSex differences play a critical role in the incidence and severity of cardiovascular diseases, whereby men are at a higher risk of...
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Angiotensin II Type 2 Receptor Agonism Alleviates Progressive Post-stroke Cognitive Impairment in Aged Spontaneously Hypertensive Rats
Hypertension and aging are leading risk factors for stroke and vascular contributions to cognitive impairment and dementia (VCID). Most animal models...
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Spontaneously hypertensive rats can become hydrocephalic despite undisturbed secretion and drainage of cerebrospinal fluid
BackgroundHydrocephalus constitutes a complex neurological condition of heterogeneous origin characterized by excessive cerebrospinal fluid (CSF)...
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Effects of reversible SERCA inhibition on catecholamine exocytosis and intracellular [Ca2+] signaling in chromaffin cells from normotensive Wistar Kyoto rats and spontaneously hypertensive rats
Intracellular Ca 2+ ([Ca 2+ ]i) signaling and catecholamine (CA) exocytosis from adrenal chromaffin cells (CCs) differ between mammalian species. These...
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In vivo symmetric multi-contrast MRI brain templates and atlas for spontaneously hypertensive rats
Spontaneously hypertensive rats (SHRs) are a valuable animal model of essential hypertension. The increasing use of SHRs in neuroimaging has...
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Effects of voluntary exercise on the expression of browning markers in visceral and subcutaneous fat tissue of normotensive and spontaneously hypertensive rats
High physical activity is important to optimize the function of adipose tissue. Dysfunctional adipose tissue contributes to the development of...
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Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats
Plasma kallikrein (PKa) has been implicated in contributing to hemorrhage following thrombolytic therapy; however, its role in spontaneous...
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Caffeine Improves GABA Transport in the Striatum of Spontaneously Hypertensive Rats (SHR)
The spontaneously hypertensive rat (SHR) is an excellent animal model that mimics the behavioral and neurochemical phenotype of...
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Treatment of male and female spontaneously hypertensive rats with TNF-α inhibitor etanercept increases markers of renal injury independent of an effect on blood pressure
Hypertension remains the leading risk factor for cardiovascular disease. Young females tend to be protected from hypertension compared with...
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Spatio-temporal dynamics of microglia phenotype in human and murine cSVD: impact of acute and chronic hypertensive states
Vascular risk factors such as chronic hypertension are well-established major modifiable factors for the development of cerebral small vessel disease...
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The Protective Role of the Long Pentraxin PTX3 in Spontaneously Hypertensive Rats with Heart Failure
Pentraxin 3 (PTX3) is synthesized locally and released into the circulation, reflecting local inflammation in the cardiovascular system. Therefore,...
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Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects
Inflammatory activation and oxidative stress promote the proliferation of vascular smooth muscle cells (VSMCs), which accounts for pathological...
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Regulation of tight junction proteins and cell death by peroxisome proliferator-activated receptor γ agonist in brainstem of hypertensive rats
The decrease in tight junction proteins and their adapter proteins in the hypertensive brain is remarkable. Here, we aimed to investigate tight...
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Acute intranasal dopamine application counteracts the reversal learning deficit of spontaneously hypertensive rats in an attentional set-shifting task
RationaleStudies on the attention-deficit/hyperactivity disorder (ADHD) have concluded that the disorder might be caused by a deficit in the...
