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Cleaved caspase-3 is present in the majority of glial cells in the intact rat spinal cord during postnatal life
Cell death is an essential process that occurs during the development of the central nervous system. Despite the availability of a wide range of...
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Glial Cells: Neuroglia
In the human brain glial cells are as abundant as neurons. The relative number of glial cells has increased with increasing complexity of the central...
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Immune and Glial Cells in Pain and Their Interactions with Nociceptive Neurons
While pain is sensed and conducted by neurons, including primary sensory neurons (nociceptors) and spinal cord pain transmission neurons, mounting...
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Glial Cells During the Life Cycle
Astrocytes, oligodendrocytes, and oligodendrocyte precursor cells have a lifelong close relationship with each other and with neurons. Radial glia...
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MiR-155-5p Aggravated Astrocyte Activation and Glial Scarring in a Spinal Cord Injury Model by Inhibiting Ndfip1 Expression and PTEN Nuclear Translocation
Central nervous injury and regeneration repair have always been a hot and difficult scientific questions in neuroscience, such as spinal cord injury...
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Human induced neural stem cells support functional recovery in spinal cord injury models
Spinal cord injury (SCI) is a clinical condition that leads to permanent and/or progressive disabilities of sensory, motor, and autonomic functions....
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A Switch from Glial to Neuronal Gene Expression Alterations in the Spinal Cord of SIV-infected Macaques on Antiretroviral Therapy
Despite antiretroviral therapy (ART), HIV-associated peripheral neuropathy remains one of the most prevalent neurologic manifestations of HIV...
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Contribution of Glial Cells to Polyglutamine Diseases: Observations from Patients and Mouse Models
Neurodegenerative diseases are broadly characterized neuropathologically by the degeneration of vulnerable neuronal cell types in a specific brain...
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Spatiotemporal Dynamics of the Molecular Expression Pattern and Intercellular Interactions in the Glial Scar Response to Spinal Cord Injury
Nerve regeneration in adult mammalian spinal cord is poor because of the lack of intrinsic regeneration of neurons and extrinsic factors – the glial...
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Spinal Cord Regeneration
Repairing the damaged spinal cord has for a long time eluded neuroscientists. Few other achievements in neuroscience would have such a tremendous...
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X-ray Irradiation Improves Neurological Function Recovery of Injured Spinal Cord by Inhibiting Inflammation and Glial Scar Formation
Spinal cord injury (SCI) is a common clinical disease that can cause permanent disruption of nerve function. Inflammation and glial scar formation...
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Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes
Amyotrophic lateral sclerosis (ALS) is a progressively fatal neurodegenerative disease affecting motor neurons in the brain and spinal cord. In this...
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Glial Cells: Neuroglia
In the human brain glial cells are as abundant as neurons. The relative number of glial cells has increased with increasing complexity of the central...
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Reprogramming of astrocytes to neuronal-like cells in spinal cord injury: a systematic review
Study designA Systematic Review
ObjectivesTo determine the therapeutic efficacy of in vivo reprogramming of astrocytes into neuronal-like cells in...
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Exosomes Derived from Mesenchymal Stem Cells: Therapeutic Opportunities for Spinal Cord Injury
Spinal cord injury (SCI) is a serious neurological condition comprising primary and secondary injury and causing severe neurological impairments. The...
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Heterogeneity and Molecular Markers for CNS Glial Cells Revealed by Single-Cell Transcriptomics
Glial cells, including astrocytes, oligodendrocytes, and microglia, are the major components in the central nervous system (CNS). Studies have...
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Effect of Electroacupuncture Stimulation on Proliferation and Differentiation of Endogenous Neural Stem Cells in Rats with Spinal Cord Injury
The aim of this work was to investigate the effects of electroacupuncture (EA) stimulation on the proliferation and differentiation of endogenous...
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Differences in the characteristics and functions of brain and spinal cord regulatory T cells
T cells play an important role in the acquired immune response, with regulatory T cells (Tregs) serving as key players in immune tolerance. Tregs are...
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Updated Understanding of the Glial-Vascular Unit in Central Nervous System Disorders
The concept of the glial-vascular unit (GVU) was raised recently to emphasize the close associations between brain cells and cerebral vessels, and...
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Evaluation of the Optimal Number of Implanted Mesenchymal Stem Cells for the Treatment of Post-Traumatic Syrinx and Recovery of Motor Activity after Chronic Spinal Cord Injury
The present work aims at determining the most effective dose (number) of mesenchymal stem cells (MSC) for its transplantation in order to treat...