Search
Search Results
-
Lipidomics profiling reveals distinct patterns of plasma sphingolipid alterations in Alzheimer’s disease and vascular dementia
BackgroundAlzheimer’s disease (AD) and vascular dementia (VaD) are two of the commonest causes of dementia in the elderly. Of the myriad biomolecules...
-
Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis
Amyotrophic lateral sclerosis (ALS) is a progressive, neurodegenerative disease of the lower and upper motor neurons with sporadic or hereditary...
-
Sphingolipids: drivers of cardiac fibrosis and atrial fibrillation
Sphingolipids (SLs) are vital constituents of the plasma membrane of animal cells and concurrently regulate numerous cellular processes. An...
-
Functional roles of sphingolipids in immunity and their implication in disease
Sphingolipids, which are components of cellular membranes and organ tissues, can be synthesized or degraded to modulate cellular responses according...
-
Neuronal Ganglioside and Glycosphingolipid (GSL) Metabolism and Disease
Glycosphingolipids (GSLs) are a diverse group of membrane components occurring mainly on the surfaces of mammalian cells. They and their metabolites...
-
Sphingolipids as Oxygen Sensors and Major Orchestrators of Cellular Responses to Hypoxia
Hypoxia, the drop in tissue oxygenation, holds a poor prognostic value in different clinicopathologic settings. In solid tumors, hypoxia induces a...
-
Genetic Tools for Studying the Roles of Sphingolipids in Viral Infections
Sphingolipids are a critical family of membrane lipids with diverse functions in eukaryotic cells, and a growing body of literature supports that...
-
Sphingosine 1-Phosphate Lyase in the Develo** and Injured Nervous System: a Dichotomy?
Sphingosine 1-phosphate lyase (SPL) is the terminal enzyme that controls the degradation of the bioactive lipid sphingosine 1-phosphate (S1P) within...
-
Biomarkers for Assessing Mycotoxin Exposure and Health Effects
A variety of adverse health effects can be determined after exposure to mycotoxins, the toxic metabolites produced by some fungi species during...
-
Tumor ratio of unsaturated to saturated sulfatide species is associated with disease-free survival in intrahepatic cholangiocarcinoma
PurposeCholangiocarcinoma (CCA) is a malignancy arising from the bile duct epithelium and has a poor outcome. Sulfatides are lipid components of...
-
Synthesis of O-Linked Glycoconjugates in the Nervous System
Glycoproteins carrying O-linked N-acetylgalactosamine, N-acetylglucosamine, mannose, fucose, glucose, and xylose are found in the nervous system....
-
Sulfatide imaging identifies tumor cells in colorectal cancer peritoneal metastases
Even with systemic chemotherapy, cytoreductive surgery (CRS), and hyperthermic intraperitoneal chemotherapy (HIPEC), peritoneal metastases (PM)...
-
Sphingosine 1-Phosphate Metabolism and Signaling
Sphingosine 1-phosphate (S1P) is a well-defined bioactive lipid molecule derived from membrane sphingolipid metabolism. In the past decades, a series...
-
Ceramides as Dietary Biomarkers
Ceramides are components of all cell membranes, regulating immune cell function and inflammation. Metabolism-wise, ceramides increase fat use as an...
-
Ceramides as Dietary Biomarkers
Ceramides are components of all cell membranes, regulating immune cell function and inflammation. Metabolism-wise, ceramides increase fat use as an...
-
Lipid Profiling in Alzheimer’s Disease
The human brain is the organ with the most lipids after adipose tissues. The rich heterogeneity of the neural lipidome is being actively investigated...
-
Changes in the Content of Sphingolipids in the Nigrostriatal Dopaminergic System in the Brain of Mice with a Neurotoxic Model of Parkinson’s Disease
Abstract —It was shown that sphingolipids are necessary for the normal functioning of neurons, and disturbance of their metabolism accompanies the...
-
Biomarkers for Assessing Mycotoxin Exposure and Health Effects
A variety of adverse health effects can be determined after exposure to mycotoxins, the toxic metabolites produced by some fungi species during...
-
Sphingolipid Metabolism and Signaling in Endothelial Cell Functions
The endothelium, inner layer of blood vessels, constitutes a metabolically active paracrine, endocrine, and autocrine organ, able to sense the...
-
Drug Development in the Field of Sphinogolipid Metabolism
Sphingolipids are the major lipid components on cellular membranes especially on lipid raft regions, intermediating various important biological...