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Population structure and haplotype network analyses of Hyalomma anatolicum based on the large subunit ribosomal RNA (16S rRNA) gene
Hyalomma anatolicum , an Anatolian hard tick is a well-recognized vector involved in the transmission of various pathogens to animals and humans. The...
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The emerging importance of METTL5-mediated ribosomal RNA methylation
The study of the epitranscriptome has thus far focused largely on mRNA methylation. Recent human genetics studies suggest that methylation of...
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Role of the RNA-binding protein ZC3H41 in the regulation of ribosomal protein messenger RNAs in trypanosomes
BackgroundTrypanosomes are single-celled eukaryotes that rely heavily on post-transcriptional mechanisms to regulate gene expression. RNA-binding...
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Deficiency of the mitochondrial ribosomal subunit, MRPL50, causes autosomal recessive syndromic premature ovarian insufficiency
Premature ovarian insufficiency (POI) is a common cause of infertility in women, characterised by amenorrhea and elevated FSH under the age of...
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Unveiling mitochondrial and ribosomal gene deregulation and tumor microenvironment dynamics in acute myeloid leukemia
Acute myeloid leukemia (AML) is a malignant clonal hematopoietic disease with a poor prognosis. Understanding the interaction between leukemic cells...
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Amplifying gene expression with RNA-targeted therapeutics
Many diseases are caused by insufficient expression of mutated genes and would benefit from increased expression of the corresponding protein....
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Specialization of RNA Polymerase I in Comparison to Other Nuclear RNA Polymerases of Saccharomyces cerevisiae
In archaea and bacteria the major classes of RNAs are synthesized by one DNA-dependent RNA polymerase (RNAP). In contrast, most eukaryotes have three...
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Clinical, genetic and structural delineation of RPL13-related spondyloepimetaphyseal dysplasia suggest extra-ribosomal functions of eL13
Spondyloepimetaphyseal dysplasia with severe short stature, RPL13 -related (SEMD-RPL13), MIM#618728), is a rare autosomal dominant disorder...
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Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer
BackgroundRibosomal biogenesis and ribosomal proteins have attracted attention in the context of tumor biology in recent years. Instead of being mere...
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Ribosomal Pulldown Assays and Their Use to Analyze Gene Expression in Multiple Inner Ear Cell Types
Research of inner ear cell development and function has greatly benefited from the advent of next-generation sequencing. Cell type-specific analysis...
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The Role of RNA-Binding Proteins in Cancers
RNA-binding proteins (RBPs) play fundamental roles in most aspects of cell regulation, specifically in post-transcriptional modifications, thanks to...
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Translating Ribosome Affinity Purification (TRAP) and Bioinformatic RNA-Seq Analysis in Post-metamorphic Xenopus laevis
Recent technical advances provide the ability to isolate and purify mRNAs from genetically distinct cell types so as to provide a broader view of...
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Activity-Dependent Labeling of Olfactory Sensory Neurons Using RNA Fluorescence In Situ Hybridization Followed by Phospho-S6 Immunofluorescence
This microscope-based method allows demonstrating that an odorant receptor responded to an odorant in vivo. In sections of olfactory epithelium from...
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Transfer RNA-derived small RNAs in tumor microenvironment
Transfer RNAs (tRNAs) are a class of non-coding RNAs responsible for amino acid translocation during protein synthesis and are ubiquitously found in...
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Epi-Drugs Targeting RNA Dynamics in Cancer
From the early discovery of ribonucleic acid in 1868, the RNA world has seen constant evolution. To date, more than ten types of RNA species are...
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The nucleolus of Giardia and its ribosomal biogenesis
G iardia duodenalis is a protozoan intestinal parasite that causes a significant number of infections worldwide each year, particularly in low-income...
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Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration
In neurons, RNA granules are transported along the axon for local translation away from the soma. Recent studies indicate that some of this transport...
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Gene Expression and Chromatin
In this chapter, principles of gene expression are discussed. An essential condition that a gene can be expressed, i.e., transcribed into RNA, is...
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The allometry of cellular DNA and ribosomal gene content among microbes and its use for the assessment of microbiome community structure
BackgroundThe determination of taxon-specific composition of microbiomes by combining high-throughput sequencing of ribosomal genes with...
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The Concept of “Virus” Is the Same as Exosomal miRNA Gene
Virus is not the Latin word for “virus,” which means simply slimy liquid or poison. In the early twentieth century, viruses were referred to as...