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Single Nucleotide Polymorphism as Evolutionary Evidence of Individuality
Since the development of DNA fingerprinting by Sir Alec Jeffery, the technique has always had a special relevance to forensic science. With the new...
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The Study of Polymorphism of the ipiO Gene Family in Oomycete Phytophthora infestans (Mont.) De Bary in the Moscow Region Population Using SSCP Analysis
AbstractThe goal of this study was to investigate the polymorphism of the primary structure of ipiO genes in the population of P. infestans from the...
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A Novel Missense SNP in the Fatty Acid-Binding Protein 4 (FABP4) Gene is Associated with Growth Traits in Karakul and Awassi Sheep
The fatty acid-binding protein 4 (FABP4) plays a crucial role in the transportation and metabolism of fatty acids. It binds to long-chain fatty acids...
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A Novel Missense Single Nucleotide Polymorphism in the GREM1 Gene is Highly Associated with Higher Reproductive Traits in Awassi Sheep
GREM1 (gremlin1) is a known inhibitor for BMP15 (bone morphogenetic protein 15) family, but its genetic diversity in sheep is unknown. The present...
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Molecular Methods for Detection of Βeta-Lactamases
Gram-negative bacterial infections are a substantial cause of health care associated morbidity and mortality among patients. β-lactam antibiotics are...
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Mitochondrial DNA Profiling
Mitochondrial DNA (mtDNA) is a versatile tool in understanding the clinical and non-clinical aspects attributed by the nucleotide sequences. The...
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Association between IL-10 gene polymorphisms (− 1082 A/G, -819 T/C, -592 A/C) and hepatocellular carcinoma: a meta-analysis and trial sequential analysis
BackgroundThe carcinogenesis of hepatocellular carcinoma is complicated, and genetic factor may have the role in the malignant transformation of...
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Advances in the genetic characterization of the malaria vector, Anopheles funestus, and implications for improved surveillance and control
Anopheles mosquitoes present a major public health challenge in sub-Saharan Africa; notably, as vectors of malaria that kill over half a million...
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Cancer of unknown primary with EGFR mutation successfully treated with targeted therapy directed by clinical next-generation sequencing: a case report
BackgroundCancer of unknown primary (CUP) is usually treated with nonselective and empirical chemotherapy; however, its prognosis is generally poor,...
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Relationship of Bovine Lymphocyte Antigen Genes with Clinical Mastitis Disease Using SSCP Technique
AbstractBoLA-A and BoLA-DRB3 are in class I and II genes of bovine lymphocyte antigen of immune system respectively which cattle express per...
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Genome-wide somatic mutation analysis of sinonasal adenocarcinoma with and without wood dust exposure
BackgroundSinonasal adenocarcinoma is a rare cancer, encompassing two different entities, the intestinal-type sinonasal adenocarcinoma (ITAC) and the...
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Effect of DNMT3A polymorphisms on CpG island hypermethylation in gastric mucosa
BackgroundCpG methylation of tumor suppressor genes occurs in the early stage of carcinogenesis. Detecting risk factors for aberrant CpG methylation...
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Untangling the KRAS mutated lung cancer subsets and its therapeutic implications
The Kirsten rat sarcoma virus transforming protein (KRAS) mutations (predominate in codons 12, 13, and 61) and genomically drive nearly one-third of...
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Vibrio cholerae
Cholera caused by toxigenic Vibrio cholerae is a major public health problem in many develo** countries, where outbreaks and sporadic infections...
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Taeniasis
Taeniasis is a zoonotic cestodeinfection of humans causedby the adult worms of Taenia saginata (“beef tapeworm”), Taenia solium (“pork tapeworm”) or...
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The prognostic impact of peritoneal tumour DNA in gastrointestinal and gynaecological malignancies: a systematic review
Peritoneal metastases from various abdominal cancer types are common and carry poor prognosis. The presence of peritoneal disease upstages cancer...
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Genetic etiology of non-syndromic hearing loss in Europe
Hearing impairment not etiologically associated with clinical signs in other organs (non-syndromic) is genetically heterogeneous, so that over 120...
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BMPR-1B, BMP-15 and GDF-9 genes structure and their relationship with litter size in six sheep breeds reared in Egypt
ObjectiveThe aim of this work was to investigate three different mutations; Fec-B, FecX G , Fec-G H at three candidate genes; Bone morphogenetic...
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Genetic diversity and haplotype analysis of Leishmania tropica identified in sand fly vectors of the genera Phlebotomus and Sergentomyia using next-generation sequencing technology
Next-generation sequencing (NGS) was used to investigate the genetic diversity of Leishmania tropica in the sand fly vector, targeting the internal...
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Fasciolosis
First chapter of the present book deals with the introduction of fasciolosis disease, their history, overall status, economic impact on livestocks...