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Single Nucleotide Polymorphisms Human Variation and a Coming Revolution in Biology and Medicine
This book explores the importance of Single Nucleotide Polymorphisms (SNPs) in biomedical research. As SNP technologies have evolved from labor...
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Association of Single Nucleotide Polymorphisms (SNPs) of Chemoattractant Receptor23 (ChemR23) Gene with Susceptibility to Allergic Rhinitis
The chemoattractant Receptor23 (ChemR23) plays an essential role in triggering and resolving acute inflammation. This study aimed to evaluate the...
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Bioinformatics Analysis of Non-Synonymous Single Nucleotide Polymorphisms in Human Adk Gene
AbstractAdenosine kinase (ADK) controls adenosine levels. Abnormal concentration of adenosine lead to multiple disorders in humans. In this study,...
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Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1
We analyzed single nucleotide polymorphisms (SNPs) in PKNOX1 (rs2839629) and in the intergenic region between PKNOX1 and CBS (rs915854) by Sanger...
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Association Analysis of 27 Single Nucleotide Polymorphisms in a Chinese Population with Essential Tremor
Genetic factors play a major role in essential tremor (ET) pathogenesis. This study aimed to assess variant burden in ET-associated genes in a...
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In Silico Functional and Structural Analysis of Non-synonymous Single Nucleotide Polymorphisms (nsSNPs) in Human Paired Box 4 Gene
In human genome, members of Paired box (PAX) transcription factor family are highly sequence-specific DNA-binding proteins. Among PAX gene family...
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The association of E2F1 and E2F2 single nucleotide polymorphisms with laryngeal squamous cell carcinoma pathomorphological features
BackgroundLaryngeal squamous cell carcinoma (LSCC) is one of the most common types of cancer in the upper respiratory tract. It is well-known that it...
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Association Between Neurodegenerative Diseases and an Increased Risk of Epilepsy Based on Single Nucleotide Polymorphisms: A Mendelian Randomization Study
Epilepsy is a common neurological disorder characterized by transient brain dysfunction, attributed to a multitude of factors. The purpose of this...
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A systematic strategy for identifying causal single nucleotide polymorphisms and their target genes on Juvenile arthritis risk haplotypes
BackgroundAlthough genome-wide association studies (GWAS) have identified multiple regions conferring genetic risk for juvenile idiopathic arthritis...
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Association of ZC3HAV1 single nucleotide polymorphisms with the susceptibility of Vogt-Koyanagi-Harada Disease
BackgroundPolymorphisms of genes related to the immune response have been reported to confer susceptibility to Vogt-Koyanagi-Harada (VKH) disease....
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Single Nucleotide Polymorphism as Evolutionary Evidence of Individuality
Since the development of DNA fingerprinting by Sir Alec Jeffery, the technique has always had a special relevance to forensic science. With the new...
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Single Nucleotide Polymorphisms in Papillary Thyroid Carcinoma: Clinical Significance and Detection by High-Resolution Melting
Single nucleotide polymorphisms (SNPs) can have a variety of implications for the progression and development of papillary thyroid carcinomas (PTCs)....
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Correlation of toxicities and efficacies of pemetrexed with clinical factors and single-nucleotide polymorphisms: a prospective observational study
BackgroundPemetrexed is an efficacious multi-targeted antifolate with acceptable toxicity for non-squamous non-small cell lung cancer (non-Sq NSCLC)...
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Single Nucleotide Polymorphisms and Pharmacogenomics
Pharmaco-genomics determines the individual genetic mechanism for drug response and has the ability to transform tailored medication into clinical...
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Single nucleotide polymorphisms in aquaporin-4 associate with cognitive impairment status in people with HIV
Neurocognitive impairments are more frequent in people with HIV (PWH) compared to their uninfected counterparts. HIV-associated neurocognitive...
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Genomic analysis of single nucleotide polymorphisms in malaria parasite drug targets
Malaria is a life-threatening parasitic disease caused by members of the genus Plasmodium . The development and spread of drug-resistant strains of Plasmodium...
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On the relationship between tripartite motif-containing 22 single-nucleotide polymorphisms and COVID-19 infection severity
BackgroundThe tripartite motif containing ( TRIM )-22 participates in innate immune responses and exhibits antiviral activities. The present study...
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Association of Single Nucleotide Polymorphisms in KCNA10 and SLC13A3 Genes with the Susceptibility to Chronic Kidney Disease of Unknown Etiology in Central Indian Patients
Global rise in the prevalence of endemic chronic kidney disease of unknown etiology (CKDu) possess major health issues. The prevalence of CKDu is...
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Toll-Like Receptor Polymorphisms and the Risk of Cancer: Meta-analysis Study
A systematic review and meta-analysis is a useful method to summarize the different results from primary data, which can then provide an...