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Short-term intensive fasting enhances the immune function of red blood cells in humans
BackgroundFasting is known to influence the immune functions of leukocytes primarily by regulating their mobilization and redistribution between the...
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Fasting and fasting-mimicking conditions in the cancer immunotherapy era
Fasting and fasting-mimicking conditions modulate tumor metabolism and remodel the tumor microenvironment (TME), which could be exploited for the...
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Short-term dietary changes can result in mucosal and systemic immune depression
Omnivorous animals, including mice and humans, tend to prefer energy-dense nutrients rich in fat over plant-based diets, especially for short periods...
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Short term starvation potentiates the efficacy of chemotherapy in triple negative breast cancer via metabolic reprogramming
BackgroundChemotherapy (CT) is central to the treatment of triple negative breast cancer (TNBC), but drug toxicity and resistance place strong...
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A blood DNA methylation biomarker for predicting short-term risk of cardiovascular events
BackgroundRecent evidence highlights the epidemiological value of blood DNA methylation (DNAm) as surrogate biomarker for exposure to risk factors...
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A patient perspective on applying intermittent fasting in gynecologic cancer
ObjectiveResearchers sought patient feedback on a proposed randomized controlled trial (RCT) in which gynecological cancer patients would modify...
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Fasting-activated ventrolateral medulla neurons regulate T cell homing and suppress autoimmune disease in mice
Dietary fasting markedly influences the distribution and function of immune cells and exerts potent immunosuppressive effects. However, the...
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The gut microbiome modifies the associations of short- and long-term physical activity with body weight changes
BackgroundThe gut microbiome regulates host energy balance and adiposity-related metabolic consequences, but it remains unknown how the gut...
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Fasting mimicking diet inhibits tumor-associated macrophage survival and pro-tumor function in hypoxia: implications for combination therapy with anti-angiogenic agent
BackgroundRecent research shows that tumor-associated macrophages (TAMs) are the primary consumers of glucose in tumor tissue, surpassing that of...
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A nested case–control study investigating short-term prognosis, clinical and imaging features in acute ischemic stroke patients with systemic lupus erythematosus
ObjectivesTo investigate acute ischemic stroke (AIS) patients with systemic lupus erythematosus (SLE) clinical and imaging features, and to explore...
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Fasting for 48 h induced similar glucose intolerance in both sexes despite greater perceived stress and decreased estradiol levels in females
PurposeThe purpose of this study was to compare the effects of fasting for 48 h on the evoked insulin and glucose responses in males and females, and...
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Understanding the Clinical Link Between Fasting and Response to Cancer Therapy
Purpose of ReviewFasting can be defined as stress on the cell due to nutrient deprivation which modulates metabolic regulation and influences several...
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Short term e-bicycle riding results in favorable cardiometabolic shifts in moderately active adults
PurposeElectric bikes (EB) are a form of active transportation with demonstrated health benefits. The purpose of this study was to determine the...
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Cancer and Fasting: Can Fasting/Calorie Restriction (CR) or Fasting-Mimicking Diet (FMD) Help Fight Cancer? Molecular Basis of Fasting Response
The ecosystem of cancer management is exploring the multiple approaches for the effective management of cancer. In the quest of integrated cancer...
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Baseline severity and soluble vascular cell adhesion molecule 1 (sVCAM-1) as biomarker predictors of short-term mortality in acute ischemic stroke
The aim was to investigate the association between plasma levels of cellular adhesion molecules (CAMs) and risk factors, subtypes, severity and...
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Dietary fasting and time-restricted eating in Huntington’s disease: therapeutic potential and underlying mechanisms
Huntington's disease (HD) is a devastating neurodegenerative disorder caused by aggregation of the mutant huntingtin (mHTT) protein, resulting from a...
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Fasting in combination with the cocktail Sorafenib:Metformin blunts cellular plasticity and promotes liver cancer cell death via poly-metabolic exhaustion
PurposeDual-Interventions targeting glucose and oxidative metabolism are receiving increasing attention in cancer therapy. Sorafenib (S) and...
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Short-term zinc supplementation of zinc-deficient seniors counteracts CREMα - mediated IL-2 suppression
BackgroundAging is accompanied by a dramatic decline in the interleukin (IL)-2 production capacity of human immune cells, thus making seniors more...
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Intermittent fasting plus early time-restricted eating versus calorie restriction and standard care in adults at risk of type 2 diabetes: a randomized controlled trial
Intermittent fasting appears an equivalent alternative to calorie restriction (CR) to improve health in humans. However, few trials have considered...
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Fasting augments pyrrolizidine alkaloid-induced hepatotoxicity
Pyrrolizidine alkaloids (PAs) are phytotoxins widely present in various natural products and foodstuffs. The present study aims to investigate the...
