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Landscapes of gut bacterial and fecal metabolic signatures and their relationship in severe preeclampsia
BackgroundPreeclampsia is a pregnancy-specific disease leading to maternal and perinatal morbidity. Hypertension and inflammation are the main...
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Gadd45 in Preeclampsia
Preeclampsia is a pregnancy-induced complex of multiple pathological changes. Numerous stresses during pregnancy, including hypoxia, immune...
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The Polymorphic Locus rs167479 of the RGL3 Gene Is Associated with the Risk of Severe Preeclampsia
AbstractIn this work, the associations of polymorphism of candidate genes of arterial hypertension with the development of severe preeclampsia (PE)...
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The Role of Nitric Oxide in the Etiopathogenesis of Preeclampsia
Preeclampsia (PE) is a severe pregnancy complication that presents mostly after twenty weeks of gestation. It can be diagnosed by increased systolic...
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Preeclampsia, antihypertensive medication use in pregnancy and risk of childhood cancer in offspring
PurposePreeclampsia is a serious pregnancy complication that presents a significant risk to both the mother and the fetus. Preeclampsia and...
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Polygenic prediction of preeclampsia and gestational hypertension
Preeclampsia and gestational hypertension are common pregnancy complications associated with adverse maternal and child outcomes. Current tools for...
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Effect of low-molecular-weight heparin calcium combined with magnesium sulfate and labetalol on coagulation, vascular endothelial function and pregnancy outcome in early-onset severe preeclampsia
ObjectiveThis paper was aimed at unveiling the effect of low-molecular-weight heparin calcium (LMWH) combined with magnesium sulfate and labetalol on...
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Impact of Survivin rs9904341 and rs17878467 Polymorphisms On Risk of Preeclampsia in Iran
Preeclampsia (PE) is a hypertensive disorder that affects pregnancy, mother, and fetus. Early diagnosis of PE remains a challenge. This study aimed...
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Placental transcriptome analysis of hypertensive pregnancies identifies distinct gene expression profiles of preeclampsia superimposed on chronic hypertension
BackgroundThe pathogenesis of preeclampsia superimposed on chronic hypertension (SI) is poorly understood relative to preeclampsia (PreE) occurring...
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Association of ACE*(Insertion/Deletion) Variant with the Elevated Risk of Preeclampsia Among Gestational Women
The renin–angiotensin–aldosterone system has an indispensable function in the uteroplacental circulation, placental growth, and blood pressure...
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Hsa_circ_0002348 regulates trophoblast proliferation and apoptosis through miR-126-3p/BAK1 axis in preeclampsia
BackgroundPreeclampsia is a common pregnancy complication characterized by high blood pressure and damage to organs. Abnormal placenta and vascular...
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Pathophysiology of Preeclampsia and L-Arginine/L-Citrulline Supplementation as a Potential Strategy to Improve Birth Outcomes
In preeclampsia, the shallow invasion of cytotrophoblast cells to uterine spiral arteries, leading to a reduction in placental blood flow, is...
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Integrated analysis of microRNA and mRNA expression profiles in Preeclampsia
BackgroundPreeclampsia (PE), a pregnancy specific syndrome, is one kind of common gestational hypertension disease, which can cause maternal and...
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Exploiting sweet relief for preeclampsia by targeting autophagy-lysosomal machinery and proteinopathy
The etiology of preeclampsia (PE), a severe complication of pregnancy with several clinical manifestations and a high incidence of maternal and fetal...
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Variants and Haplotypes of SIRT1 (rs7895833, rs7069102, and rs2273773) are Associated with the Risk of Preeclampsia and Affect the Trace Elements and Antioxidant Enzymes Levels
Preeclampsia is the most common and serious complication of pregnancy. Variants of Sirtuin-1 (SIRT1) as a key player in the regulation of...
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Platelet mitochondrial membrane depolarization reflects disease severity in patients with preeclampsia
BackgroundThrombocytopenia is a feared complication of preeclampsia (PE) that can additionally complicate the disease course and that carries a poor...
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Circulating Non-coding RNAs and Exosomes: Liquid Biopsies for Monitoring Preeclampsia
Preeclampsia (PE) remains a leading cause of maternal and fetal mortality, due to ineffective treatment and diagnostic strategies, compounded by the...
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Genes TMEM136 and PPP1R12C Differentially Expressed in the Placenta Are Associated with Preeclampsia
AbstractThe associations of genes differentially expressed in the placenta with the risk of preeclampsia in women in Central Russia were studied. The...
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The diagnostic potential of oxidative stress biomarkers for preeclampsia: systematic review and meta-analysis
BackgroundPreeclampsia is a multifactorial cardiovascular disorder of pregnancy. If left untreated, it can lead to severe maternal and fetal...
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Transcriptomic Profiling of Placental Cells in Preeclampsia as an Effective Tool for Personalized Medicine
AbstractAt present, transcriptomics is one of the fastest develo** fields of molecular biology, which allows to obtain detailed information about...
