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Bone regeneration in osteoporosis: opportunities and challenges
Osteoporosis is a bone disorder characterised by low bone mineral density, reduced bone strength, increased bone fragility, and impaired...
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Rare Immune-Related Adverse Events (irAEs): Approach to Diagnosis and Management
Immune checkpoint inhibitors (ICIs) have revolutionised the treatment landscape across many solid organ malignancies and form part of routine...
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COVID Diagnostics: From Molecules to Omics
The identification and genetic sequencing of a novel coronavirus was key to the diagnosis and management of the global pandemic. An understanding of...
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Impact of age on central lymph nodes involvement in papillary thyroid cancer
BackgroundTotal thyroidectomy is the main line of treatment for papillary thyroid cancer. Central lymph node dissection (CLND) is still debatable. In...
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Equecabtagene Autoleucel: First Approval
Equecabtagene autoleucel (Fucaso ® ), an autologous anti-B cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR)-T cell therapy that...
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Endocrine Toxicities Related to Immunotherapy
Understanding of the mechanisms by which cancer cells evade T-cell immunity through interaction with a number of ligands has led to the introduction...
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A phase III randomized, double-blind, placebo-controlled trial of the denosumab biosimilar QL1206 in postmenopausal Chinese women with osteoporosis and high fracture risk
The current study evaluated the efficacy and safety of a denosumab biosimilar, QL1206 (60 mg), compared to placebo in postmenopausal Chinese women...
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Immunodeficiency Diseases
Immunodeficiency disorders are conditions where the defence mechanism of the body is impaired. They show enhanced susceptibility to infection with...
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Inborn errors of thymic stromal cell development and function
As the primary site for T cell development, the thymus is responsible for the production and selection of a functional, yet self-tolerant T cell...
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Microorganisms in Pathogenesis and Management of Guillain–Barré Syndrome (GBS)
Guillain–Barré syndrome (GBS) is an autoimmune disorder of the peripheral nervous system encompassing clinically heterogenous group of diseases such...
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Oncologic Emergencies: Pathophysiology, Diagnosis, and Initial Management
The rate of cancer patients will continue to increase in the coming decades. Additionally, new treatments will continue to emerge. The increased...
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Novel genetic variants of KHDC3L and other members of the subcortical maternal complex associated with Beckwith–Wiedemann syndrome or Pseudohypoparathyroidism 1B and multi-locus imprinting disturbances
BackgroundBeckwith–Wiedemann syndrome (BWS) and Pseudohypoparathyroidism type 1B (PHP1B) are imprinting disorders (ID) caused by deregulation of the...
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Beyond Bone: Infectious Diseases and Immunity in Parathyroid Disorders
Parathyroid disorders are characterized by alterations in calcium and phosphate homeostasis due to inappropriately high or low levels of parathyroid...
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Fluoride levels and biochemical assessments in cattle accidentally exposed to hydrofluoric acid in Korea
On September 27, 2012, an explosion from hydrofluoric acid occurred in Gumi city of Gyeongbuk province, Republic of Korea, exposing livestock animals...
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General Principles of Cancer Chemotherapy
Cancer chemotherapy is defined as the application of drugs that cause a lethal cytotoxic effect on malignant (cancerous) cells so as to arrest tumour...
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Immunoadsorption versus double-dose methylprednisolone in refractory multiple sclerosis relapses
ObjectiveIntravenous methylprednisolone is the standard treatment for a multiple sclerosis relapse; however, this fails to improve symptoms in up to...
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Neonatal seizures as onset of Inborn Errors of Metabolism (IEMs): from diagnosis to treatment. A systematic review
Neonatal seizures (NS) occur in the first 28 days of life; they represent an important emergency that requires a rapid diagnostic work-up to start a...
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Physical Exercise as a Strategy to Reduce Seizure Susceptibility
Neuroprotective and antiepileptogenic therapies have been extensively used for prevention and treatment of epilepsy. This chapter focuses on the...
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Advanced glycosylation end products promote the progression of CKD-MBD in rats, and its natural inhibitor, quercetin, mitigates disease progression
Chronic kidney disease–mineral and bone metabolism disorder (CKD-MBD) is a common chronic kidney disease (CKD)-associated complication that increases...
