Search
Search Results
-
Effects of time of the day at sampling on CSF and plasma levels of Alzheimer’ disease biomarkers
BackgroundStudies suggest that cerebrospinal fluid (CSF) levels of amyloid-β (Aβ)42 and Aβ40 present a circadian rhythm. However sustained sampling...
-
Pharmacokinetics of Imatinib Mesylate and Development of Limited Sampling Strategies for Estimating the Area under the Concentration–Time Curve of Imatinib Mesylate in Palestinian Patients with Chronic Myeloid Leukemia
Background and ObjectiveImatinib is a tyrosine kinase inhibitor used in the treatment of chronic myeloid leukemia (CML). The area under the...
-
Sampling Types and Methods
Sampling is the process of selecting an ideal sample that would represent the entire population of your desired study. It usually consists of a...
-
Face mask sampling (FMS) for tuberculosis shows lower diagnostic sensitivity than sputum sampling in Guinea
BackgroundPulmonary tuberculosis (PTB) diagnosis relies on sputum examination, a challenge in sputum-scarce patients. Alternative non-invasive...
-
Effect of Sampling Frequency on a Unilateral Isometric Hamstring Strength Assessment Using Force Plates
The purpose of this study was to determine the effect of sampling frequency on the 90–90° (90-degrees hip and knee flexion) isometric hamstring...
-
-
Clinical Bridging Studies and Modeling Approach for Implementation of a Patient Centric Sampling Technique in Padsevonil Clinical Development
Volumetric absorptive microsampling (VAMS) techniques have gained popularity these last years as innovative tool for collection of blood...
-
Self-Sampling by Adolescents at Home: Assessment of the Feasibility to Successfully Collect Blood Microsamples by Inexperienced Individuals
Blood microsampling has increasingly attracted interest in the past decades as a more patient-centric sampling approach, offering the possibility to...
-
Derivation of metabolic point of departure using high-throughput in vitro metabolomics: investigating the importance of sampling time points on benchmark concentration values in the HepaRG cell line
Amongst omics technologies, metabolomics should have particular value in regulatory toxicology as the measurement of the molecular phenotype is the...
-
HPV self-sampling among women in the United States: preferences for implementation
PurposeWith the inclusion of primary HPV testing in 2018 U.S. Preventive Services Taskforce guidelines, at-home HPV self-sampling may provide a...
-
The Effect of Sampling Cannula on In Vitro Dissolution Testing with USP Paddle Method
In vitro dissolution tests are widely used as quality control tools for drug products in development and manufacturing. Dissolution acceptance...
-
Assessing the efficacy of target adaptive sampling long-read sequencing through hereditary cancer patient genomes
Innovations in sequencing technology have led to the discovery of novel mutations that cause inherited diseases. However, many patients with...
-
Characterization of Freezing Processes in Drug Substance Bottles by Ice Core Sampling
Freezing of biological drug substance (DS) is a critical unit operation that may impact product quality, potentially leading to protein aggregation...
-
Sampling approaches and geographic coverage in Mayi Kuwayu: the national study of Aboriginal and Torres Strait Islander wellbeing
ObjectiveThe objective of this paper is to investigate the geographic distribution of participants in Mayi Kuwayu, the National Study of Aboriginal...
-
Evaluation of the solar-powered Silver Bullet 2.1 (Lumin 8) light trap for sampling malaria vectors in western Kenya
BackgroundCenters for Disease Control and Prevention (CDC) light traps are widely used for sampling mosquitoes. However, this trap, manufactured in...
-
Contact investigations for antibiotic-resistant bacteria: a mixed-methods study of patients’ comprehension of and compliance with self-sampling requests post-discharge
BackgroundContact investigation is an important tool to identify unrecognized patients who are colonized with antibiotic-resistant bacteria. Many...
-
Fractal Time Series: Background, Estimation Methods, and Performances
Over the past 40 years, from its classical application in the characterization of geometrical objects, fractal analysis has been progressively...
-
Population pharmacokinetics and limited sampling strategy for therapeutic drug monitoring of mycophenolate mofetil in Japanese patients with lupus nephritis
BackgroundMycophenolate mofetil (MMF), a prodrug of the immunosuppressive agent mycophenolic acid (MPA), is difficult to administer because of the...
-
Does Sample Size, Sampling Strategy, or Handling of Concentrations Below the Lower Limit of Quantification Matter When Externally Evaluating Population Pharmacokinetic Models?
Background and ObjectivesPrecision dosing requires selecting the appropriate population pharmacokinetic model, which can be assessed through external...
-
Feasibility and applicability of self-sampling based online cervical cancer screening: findings from the China online cervical cancer screening trial
ObjectiveThis study aims to evaluate the feasibility and applicability of an online cervical cancer screening program using a website as the public...
