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Diagnostic performance of RT-PCR-based sample pooling strategy for the detection of SARS-CoV-2
BackgroundThe rapid spread of SARS-CoV-2 has created a shortage of supplies of reagents for its detection throughout the world, especially in Latin...
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A capture methyl-seq protocol with improved efficiency and cost-effectiveness using pre-pooling and enzymatic conversion
ObjectiveThe opportunities for sequencing-based methylome analysis of clinical samples are increasing. To reduce its cost and the amount of genomic...
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Reproductive factors, hormonal interventions, and gastric cancer risk in the Stomach cancer Pooling (StoP) Project
BackgroundGastric cancer incidence is higher in men, and a protective hormone-related effect in women is postulated. We aimed to investigate and...
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Application of dried blood spot sample pooling strategies for Plasmodium 18S rRNA biomarker testing to facilitate identification of infected persons in large-scale epidemiological studies
BackgroundPlasmodium 18S rRNA is a sensitive biomarker for detecting Plasmodium infection in human blood. Dried blood spots (DBS) are a practical...
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Brain gray matter reduction and premature brain aging after breast cancer chemotherapy: a longitudinal multicenter data pooling analysis
Brain gray matter (GM) reductions have been reported after breast cancer chemotherapy, typically in small and/or cross-sectional cohorts, most...
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Pooling Nasopharyngeal Swab Specimens to Improve Testing Capacity for SARS-CoV-2 by Real-Time RT-PCR
BackgroundThe detection of SARS-CoV-2 using qRT-PCR with the pooling of samples can reduce workload and costs especially when the prevalence rate of...
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Pooling of samples to optimize SARS-CoV-2 diagnosis by RT-qPCR: comparative analysis of two protocols
This study has aimed to evaluate the use pool of samples as a strategy to optimize the diagnostic of SARS-CoV-2 by RT-qPCR. A total of 220...
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Chagas parasite classification in blood sample images using different machine learning architectures
Chagas disease is a life-threatening illness mainly found in Latin America. Early identification and diagnosis of Chagas disease are critical for...
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Automatic diagnosis of late-life depression by 3D convolutional neural networks and cross-sample Entropy analysis from resting-state fMRI
Resting-state fMRI has been widely used in investigating the pathophysiology of late-life depression (LLD). Unlike the conventional linear approach,...
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Alzheimer blood biomarkers: practical guidelines for study design, sample collection, processing, biobanking, measurement and result reporting
Alzheimer’s disease (AD), the most common form of dementia, remains challenging to understand and treat despite decades of research and clinical...
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Performance Evaluation of Three DNA Sample Tracking Tools in a Whole Exome Sequencing Workflow
IntroductionNext-generation sequencing applications are becoming indispensable for clinical diagnostics. These experiments require numerous wet- and...
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Decontamination, pooling and dereplication of the 678 samples of the Marine Microbial Eukaryote Transcriptome Sequencing Project
ObjectivesComplex algae are photosynthetic organisms resulting from eukaryote-to-eukaryote endosymbiotic-like interactions. Yet the specific lineages...
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Flexible upscaling of laboratory PCR testing capacity at the Robert Koch Institute during the SARS-CoV-2 pandemic
BackgroundOver the course of the COVID-19 pandemic, laboratories worldwide have been facing an unprecedented increase in demand for PCR testing...
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Implementation of pooled saliva tests for universal screening of cCMV infection
Congenital cytomegalovirus (cCMV) is the most common intrauterine infection, leading to neurodevelopmental disabilities. Universal newborn infant...
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Scalogram-Based Gait Abnormalities Classification Using Deep Convolutional Networks for Neurological and Non-Neurological Disorders
PurposeIn the present day, there is a steep increase in cases of neurological and non-neurological diseases that may affect a person’s normal gait....
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Sample Preparation for Proteomic Analysis of Cerebrospinal Fluid
This protocol describes sample preparation of CSF Cerebrospinal fluid (CSF) for proteomic Proteomics analysis by LC-MS Liquid Chromatography-Mass...
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A lightweight bladder tumor segmentation method based on attention mechanism
AbstractIn the endoscopic images of bladder, accurate segmentation of different grade bladder tumor from blurred boundary regions and highly variable...
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Quantitative Proteomics of Nervous System Regeneration: From Sample Preparation to Functional Data Analyses
Mammals have a limited regenerative capacity, especially of the central nervous system. Consequently, any traumatic injury or neurodegenerative...
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Tenfold difference in DNA recovery rate: systematic comparison of whole blood vs. dried blood spot sample collection for malaria molecular surveillance
BackgroundMolecular and genomic surveillance is becoming increasingly used to track malaria control and elimination efforts. Blood samples can be...
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Novel application of one-step pooled molecular testing and maximum likelihood approaches to estimate the prevalence of malaria parasitaemia among rapid diagnostic test negative samples in western Kenya
BackgroundDetection of malaria parasitaemia in samples that are negative by rapid diagnostic tests (RDTs) requires resource-intensive molecular...
