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Electrophysiological Studies Support Utility of Positive Modulators of SK Channels for the Treatment of Spinocerebellar Ataxia Type 2
Spinocerebellar ataxia type 2 (SCA2) is an incurable hereditary disorder accompanied by cerebellar degeneration following ataxic symptoms. The...
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Elucidating the role of hypoxia/reoxygenation in hippocampus-dependent memory impairment: do SK channels play role?
Professionals and mountaineers often face the problem of reperfusion injury due to re-oxygenation, upon their return to sea-level after sojourn at...
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Ion Channels as Drug Targets in Atrial Fibrillation
Atrial fibrillation is triggered when an abnormal electrical impulse encounters a substrate that allows initiation of re-entry. The arrhythmia has a...
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Therapeutic Targeting of Potassium Channels
Potassium (K+) channels are the largest group of ion channels in mammals. The immediate function of these channels is electrogenic transport of K+...
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Cardiac small-conductance calcium-activated potassium channels in health and disease
Small-conductance Ca 2+ -activated K + (SK, K Ca 2) channels are encoded by KCNN genes, including KCNN 1, 2, and 3. The channels play critical roles in the...
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Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels
Small- and intermediate-conductance Ca 2+ -activated K + (K Ca 2.x/K Ca 3.1 also called SK/IK) channels are gated exclusively by intracellular Ca 2+ . The Ca 2+ ...
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Ion Channels and Metal Ions in Parkinson’s Disease: Historical Perspective to the Current Scenario
Parkinson’s disease (PD) is a neurodegenerative condition linked to the deterioration of motor and cognitive performance. It produces degeneration of...
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The Role οf Ion Channels in the Development and Progression of Prostate Cancer
Ion channels have major regulatory functions in living cells. Apart from their role in ion transport, they are responsible for cellular...
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Overexpression of KCNN4 channels in principal neurons produces an anti-seizure effect without reducing their coding ability
Gene therapy offers a potential alternative to the surgical treatment of epilepsy, which affects millions of people and is pharmacoresistant in ~30%...
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Signal Transduction-Dependent Channels
From the moment the first member of this ion channel family, Slo1, was discovered, the scientific world was confronted with a molecular Pandora’s...
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Cardiac Ion Channels and Heart Rate and Rhythm
The excitability of the heart is a prerequisite for its function as a pump distributing blood throughout the body. Initiated in the sinoatrial node,...
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Altered neural cell junctions and ion-channels leading to disrupted neuron communication in Parkinson’s disease
Parkinson’s disease (PD) is a neurological disorder that affects the movement of the human body. It is primarily characterized by reduced dopamine...
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Diversity and Functional Features of Calcium-Dependent Potassium Channels as Determinants of Their Role in the Plasticity of Cerebral Neurons
The unique characteristics of calcium-dependent potassium channels are tightly intertwined with the features of their functioning, their dynamics,...
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Calcium-Activated K+ Channels (KCa) and Therapeutic Implications
Potassium channels are the most diverse and ubiquitous family of ion channels found in cells. The Ca2+ and voltage gated members form a subfamily...
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Cardiac K+ Channels and Channelopathies
The physiological heart function is controlled by a well-orchestrated interplay of different ion channels conducting Na+, Ca2+ and K+. Cardiac K+...
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Co-localization of influenza A virus and voltage-dependent calcium channels provides new perspectives on the internalization process in pigs
Influenza A virus (IAV) is an RNA virus that causes respiratory disease in a wide range of mammals including humans and pigs. Ca v 1.2 is a specific...
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Potassium Channels in Cancer
Neoplastic transformation is reportedly associated with alterations of the potassium transport across plasma and intracellular membranes. These...
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Antidepressant activity of pharmacological and genetic deactivation of the small-conductance calcium-activated potassium channel subtype-3
RationaleThe voltage-insensitive, small-conductance calcium-activated potassium (SK) channel is a key regulator of neuronal depolarization and is...
