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Multi-arm RNA junctions encoding molecular logic unconstrained by input sequence for versatile cell-free diagnostics
Applications of RNA-based molecular logic have been hampered by sequence constraints imposed on the input and output of the circuits. Here we show...
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Technologies to Study Genetics and Molecular Pathways
Over the last few decades, the study of congenital heart disease (CHD) has benefited from various model systems and the development of molecular...
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Limitations and opportunities of technologies for the analysis of cell-free DNA in cancer diagnostics
Cell-free DNA (cfDNA) in the circulating blood plasma of patients with cancer contains tumour-derived DNA sequences that can serve as biomarkers for...
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The Potential of Nanobodies for COVID-19 Diagnostics and Therapeutics
The infectious severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent for coronavirus disease 2019 (COVID-19). Globally,...
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Nationwide molecular survey of Dirofilaria immitis and Dirofilaria repens in companion dogs and cats, United States of America
BackgroundHeartworms, Dirofilaria immitis , are known to be widespread in dogs and cats in the USA, but there have been no country-wide prevalence...
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Dealing with Pseudogenes in Molecular Diagnostics in the Next Generation Sequencing Era
Presence of pseudogenes is a dreadful issue in next generation sequencing (NGS), because their contamination can interfere with the detection of...
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A high leukocyte count and administration of hydrocortisone hamper PCR-based diagnostics for bloodstream infections
Bloodstream infections (BSIs) require an accurate and fast identification of causative pathogens. Molecular diagnostics, in particular polymerase...
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Nationwide quality assurance of high-throughput diagnostic molecular testing during the SARS-CoV-2 pandemic: role of the Belgian National Reference Centre
Since the onset of the coronavirus disease (COVID-19) pandemic in Belgium, UZ/KU Leuven has played a crucial role as the National Reference Centre...
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Clinical evaluation of a fully automated and high-throughput molecular testing system for detection of influenza virus
IntroductionWe investigated the performance of the cobas® 6800 system and cobas SARS-CoV-2 & Influenza A/B, a fully automated molecular testing...
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Biochemical, Molecular, and Computational Techniques for the Determination of Virulence Factors of ESKAPE Pathogens
Emerging antibiotic resistance and its spreading dynamics have reached an alarming level, a global challenge. Overuse and Misuse of effective...
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Multiplex Technologies in COVID-19 Research, Diagnostics, and Prognostics: Battling the Pandemic
Due to continuous technical developments and new insights into the high complexity of infectious diseases such as COVID-19, there is an increasing...
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Molecular Detection and Genoty** of Cryptosporidium spp. Isolates from Bats in Colombia
PurposeCryptosporidiosis is a zoonotic infectious disease caused by the protozoan parasite Cryptosporidium spp., frequently found in several animal...
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Custom gene expression panel for evaluation of potential molecular markers in hepatocellular carcinoma
BackgroundHepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide. It is a highly heterogeneous disease with...
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Companion Diagnostics and Clinical Biomarkers for Immunotherapy
The advancement of understanding the complexity of disease biology unraveled many targets, and accordingly, their ligands are investigated. However,...
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Comparison between Aptima® assays (Hologic) and the CoBAS® 6800 system (Roche) for the diagnosis of sexually transmitted infections caused by Chlamydia trachomatis, Neisseria gonorrhoeae, and Mycoplasma genitalium
Nowadays, it is of utmost importance to use fully validated assays for molecular-based diagnosis. In the field of sexually transmitted disease (STD),...
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Molecular profiling of advanced solid tumours. The impact of experimental molecular-matched therapies on cancer patient outcomes in early-phase trials: the MAST study
IntroductionMolecular-matched therapies have revolutionized cancer treatment. We evaluated the improvement in clinical outcomes of applying an...
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Omics in Tuberculosis Diagnosis: Today and Tomorrow
The term “omics” refers to collective high-throughput approaches that include genomics, transcriptomics, proteomics and metabolomics. Primary focus...
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Molecular characterization and distribution of motilin and motilin receptor in the Japanese medaka Oryzias latipes
Motilin (MLN) is a peptide hormone originally isolated from the mucosa of the porcine intestine. Its orthologs have been identified in various...
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Epidemiological study of unusual rotavirus strains and molecular characterization of emerging P[14] strains isolated from children with acute gastroenteritis during a 15-year period
Rotavirus group A (RVA) is characterized by molecular and epidemiological diversity. To date, 42 G and 58 P RVA genotypes have been identified, some...
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Introduction to Advanced Diagnostics in Microbiology
Over the last few years, the world of clinical and environmental microbiology experienced a revolution with the introduction of new diagnostic...