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A Novel Retrograde AAV Variant for Functional Manipulation of Cortical Projection Neurons in Mice and Monkeys
Retrograde adeno-associated viruses (AAVs) are capable of infecting the axons of projection neurons and serve as a powerful tool for the anatomical...
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Recombinase-independent AAV for anterograde transsynaptic tracing
Viral transsynaptic labeling has become indispensable for investigating the functional connectivity of neural circuits in the mammalian brain....
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Intraparenchymal convection enhanced delivery of AAV in sheep to treat Mucopolysaccharidosis IIIC
BackgroundMucopolysaccharidosis IIIC (MPSIIIC) is one of four Sanfilippo diseases sharing clinical symptoms of severe cognitive decline and shortened...
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The tyrosine capsid mutations on retrograde adeno-associated virus accelerates gene transduction efficiency
Adeno-associated virus (AAV) vector is a critical tool for gene delivery through its durable transgene expression and safety profile. Among many...
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Brain-wide TVA compensation allows rabies virus to retrograde target cell-type-specific projection neurons
Retrograde tracers based on viral vectors are powerful tools for the imaging and manipulation of upstream neural networks projecting to a specific...
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Loss of MBNL1-mediated retrograde BDNF signaling in the myotonic dystrophy brain
Reduced brain volume including atrophy in grey and white matter is commonly seen in myotonic dystrophy type 1 (DM1). DM1 is caused by an expansion of...
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HiRet/NeuRet Vectors: Lentiviral System for Highly Efficient Gene Transfer Through Retrograde Axonal Transport
Lentiviral vectors are used for a wide range of research applications in the field of neuroscience. Notably, lentiviral tropism can be manipulated by...
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A novel H129-based anterograde monosynaptic tracer exhibits features of strong labeling intensity, high tracing efficiency, and reduced retrograde labeling
BackgroundViral tracers are important tools for map** brain connectomes. The feature of predominant anterograde transneuronal transmission offers...
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Intracellular trafficking of adeno-associated virus (AAV) vectors: challenges and future directions
In the last two decades, recombinant adeno-associated virus has emerged as the most popular gene therapy vector. Recently AAV gene therapy has been...
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Crossing the blood-brain barrier with AAV vectors
Central nervous system (CNS) diseases are some of the most difficult to treat because the blood-brain barrier (BBB) almost entirely limits the...
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Development of a rabies virus-based retrograde tracer with high trans-monosynaptic efficiency by reshuffling glycoprotein
Rabies virus (RV) is the most widely used vector for map** neural circuits. Previous studies have shown that the RV glycoprotein can be a target to...
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Viruses for Systemic Delivery
Adeno-associated virus (AAV) is a nonpathogenic virus that has been leveraged as a gene-delivery vector due to its high transduction efficiency in...
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Axonal autophagic vesicle transport in the rat optic nerve in vivo under normal conditions and during acute axonal degeneration
Neurons pose a particular challenge to degradative processes like autophagy due to their long and thin processes. Autophagic vesicles (AVs) are...
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Adeno-associated virus infection and its impact in human health: an overview
Discovered as a contaminant of adenovirus stocks in the 1960s, adeno-associated virus (AAV) is a mono-stranded DNA virus that depends on helper...
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Targeting Large-Conductance Calcium-Activated Potassium Channels to Ameliorate Lipopolysaccharide-Induced Depressive-Like Behavior in Mice
Neuroinflammation plays crucial role in the development and progression of depression. Large conductance calcium- and voltage-dependent potassium...
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Transduction patterns in the CNS following various routes of AAV-5-mediated gene delivery
Various administration routes of adeno-associated virus (AAV)-based gene therapy have been examined to target the central nervous system to answer...
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Origin of thyrotropin-releasing hormone neurons that innervate the tuberomammillary nuclei
Hypophysiotropic thyrotropin-releasing hormone (TRH) neurons function as metabolic sensors that regulate the thyroid axis and energy homeostasis....
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Morphological Tracing and Functional Identification of Monosynaptic Connections in the Brain: A Comprehensive Guide
Behavioral studies play a crucial role in unraveling the mechanisms underlying brain function. Recent advances in optogenetics, neuronal ty** and...
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Prospective approaches to gene therapy computational modeling – spotlight on viral gene therapy
Clinical studies have found there still exists a lack of gene therapy dose-toxicity and dose-efficacy data that causes gene therapy dose selection to...
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Dual medial prefrontal cortex and hippocampus projecting neurons in the paraventricular nucleus of the thalamus
The paraventricular nucleus (PVT) of the midline thalamus is a critical higher-order cortico-thalamo-cortical integration site that plays a critical...
