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Beyond assembly: the increasing flexibility of single-molecule sequencing technology
The maturation of high-throughput short-read sequencing technology over the past two decades has shaped the way genomes are studied. Recently,...
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Screening of small molecule compounds targeting hnRNPA2 protein
Heterogeneous nuclear ribonucleoprotein A2, as an RNA binding protein, participates in the processing and metabolism of RNA molecules. HnRNPA2 is...
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Direct transposition of native DNA for sensitive multimodal single-molecule sequencing
Concurrent readout of sequence and base modifications from long unamplified DNA templates by Pacific Biosciences of California (PacBio)...
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Next-generation neuropeptide Y receptor small-molecule agonists inhibit mosquito-biting behavior
BackgroundFemale Aedes aegypti mosquitoes can spread disease-causing pathogens when they bite humans to obtain blood nutrients required for egg...
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SARS-CoV-2 Resistance to Small Molecule Inhibitors
Purpose of the ReviewSARS-CoV-2 undergoes genetic mutations like many other viruses. Some mutations lead to the emergence of new Variants of Concern...
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Recent Advances in Organic Small-Molecule Fluorescent Probes for the Detection of Zinc Ions (Zn2+)
Zinc(II) ions (Zn 2g ) play crucial roles in the growth, propagation, and metabolism of animals, plants, and humans. Abnormal concentrations of Zn 2+ in...
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Reference Materials for Improving Reliability of Multiomics Profiling
High-throughput technologies for multiomics or molecular phenomics profiling have been extensively adopted in biomedical research and clinical...
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Single-molecule methylation profiles of cell-free DNA in cancer with nanopore sequencing
Epigenetic characterization of cell-free DNA (cfDNA) is an emerging approach for detecting and characterizing diseases such as cancer. We developed a...
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Real-time single-molecule imaging of transcriptional regulatory networks in living cells
Gene regulatory networks drive the specific transcriptional programmes responsible for the diversification of cell types during the development of...
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A Review on Small Molecule Based Fluorescence Chemosensors for Bioimaging Applications
This review provides a thorough examination of small molecule-based fluorescence chemosensors tailored for bioimaging applications, showcasing their...
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Reference intervals for plasma amyloid-β, total tau, and phosphorylated tau181 in healthy elderly Chinese individuals without cognitive impairment
BackgroundPlasma amyloid-β (Aβ) peptides and tau proteins are promising biomarkers of Alzheimer’s disease (AD), not only for predicting Aβ and tau...
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Solvent Effects on the Absorption and Emission Spectra of the [5-amino-1-bromoindolizin-3-yl](4-bromophenyl)methanone Molecule
The effects of solvent on the absorption and emission spectra and dipole moments of the 5ABBM have been extensively studied in a series of solvents....
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The use of single-molecule FRET for the characterization of Holliday junctions containing human telomeric DNA: a methodological approach for nanoscale distance, mobility, and stability measurements
Single-molecule analysis has emerged as a powerful biophysical technique, allowing the investigation of molecular interactions at unprecedented...
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Clinically relevant small-molecule promotes nerve repair and visual function recovery
Adult mammalian injured axons regenerate over short-distance in the peripheral nervous system (PNS) while the axons in the central nervous system...
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In-silico identification of small molecule benzofuran-1,2,3-triazole hybrids as potential inhibitors targeting EGFR in lung cancer via ligand-based pharmacophore modeling and molecular docking studies
Lung cancer is one of the most common and deadly types of cancer worldwide, and the epidermal growth factor receptor (EGFR) has emerged as a...
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Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference map**
The functional diversity of natural killer (NK) cell repertoires stems from differentiation, homeostatic, receptor–ligand interactions and...
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NMI Functions as Immuno-regulatory Molecule in Sepsis by Regulating Multiple Signaling Pathways
Sepsis-induced tissue and organ damage is caused by an overactive inflammatory response, immune dysfunction, and coagulation dysfunction....
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Discovery of a small molecule ligand of FRS2 that inhibits invasion and tumor growth
PurposeAberrant activation of the fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases drives oncogenic signaling through its...
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Full-Length Characterization of Novel HLA-DRB1 Alleles for Reference Database Submission
The prerequisite for successful HLA genoty** is the integrity of the large allele reference database IPD-IMGT/HLA. Consequently, it is in the...
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Discovery of a small molecule that inhibits Bcl-3-mediated cyclin D1 expression in melanoma cells
Molecular targeted therapy using a drug that suppresses the growth and spread of cancer cells via inhibition of a specific protein is a foundation of...
