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Recombination analysis on the receptor switching event of MERS-CoV and its close relatives: implications for the emergence of MERS-CoV
BackgroundPlMERS-CoV is a coronavirus known to cause severe disease in humans, taxonomically classified under the subgenus Merbecovirus. Recent...
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A quadruple recombination event discovered in hepatitis E virus
Hepatitis E virus (HEV) can infect humans, pigs, and many other animals, but recombination in HEV has rarely been reported. In the present study,...
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Divergence and conservation of the meiotic recombination machinery
Sexually reproducing eukaryotes use recombination between homologous chromosomes to promote chromosome segregation during meiosis. Meiotic...
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Profiling genome-wide recombination in Epstein Barr virus reveals type-specific patterns and associations with endemic-Burkitt lymphoma
BackgroundEndemic Burkitt lymphoma (eBL) is potentiated through the interplay of Epstein Barr virus (EBV) and holoendemic Plasmodium falciparum ...
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Predicting recombination suppression outside chromosomal inversions in Drosophila melanogaster using crossover interference theory
Recombination suppression in chromosomal inversion heterozygotes is a well-known but poorly understood phenomenon. Surprisingly, recombination...
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Predicting recombination frequency from map distance
Map distance is one of the key measures in genetics and indicates the expected number of crossovers between two loci. Map distance is estimated from...
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The Role of Extensive Recombination in the Evolution of Geminiviruses
Mutation, recombination and pseudo-recombination are the major forces driving the evolution of viruses by the generation of variants upon which...
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Recombination of variable and host range regions of glycoprotein gp85 in different avian leukosis virus subgroup K isolates
Given the high prevalence of avian leukosis virus subgroup K (ALV-K) in chickens in China, the positive rate of ALV-K in local chickens in Henan...
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Exploring the diversity and evolution of tombus-like viruses: phylogenetic analysis, recombination events, and suppressor protein homologs
This study focuses on the phylogenetic analysis of previously unclassified tombus-like viruses, which are characterized by the presence of homologs...
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Multi-scale characterisation of homologous recombination deficiency in breast cancer
BackgroundHomologous recombination is a robust, broadly error-free mechanism of double-strand break repair, and deficiencies lead to PARP inhibitor...
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Genetic recombination among tomato yellow leaf curl virus isolates in commercial tomato crops in Kuwait drives emergence of virus diversity: a comparative genomic analysis
ObjectiveWhitefly-transmitted tomato yellow leaf curl virus (TYLCV) continues to be a major constraint to tomato production in Kuwait. However, very...
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Chromothripsis followed by circular recombination drives oncogene amplification in human cancer
The mechanisms behind the evolution of complex genomic amplifications in cancer have remained largely unclear. Using whole-genome sequencing data of...
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Selection, recombination and population history effects on runs of homozygosity (ROH) in wild red deer (Cervus elaphus)
The distribution of runs of homozygosity (ROH) may be shaped by a number of interacting processes such as selection, recombination and population...
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Genetic diversity, reassortment, and recombination of mammalian orthoreoviruses from Japanese porcine fecal samples
Mammalian orthoreoviruses (MRVs) are non-enveloped double-stranded RNA viruses with a broad host range. MRVs are prevalent worldwide, and in Japan,...
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Recombination and lineage-specific mutations linked to the emergence of SARS-CoV-2
BackgroundThe emergence of SARS-CoV-2 underscores the need to better understand the evolutionary processes that drive the emergence and adaptation of...
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Multiomic analysis of homologous recombination-deficient end-stage high-grade serous ovarian cancer
High-grade serous ovarian cancer (HGSC) is frequently characterized by homologous recombination (HR) DNA repair deficiency and, while most such...
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Homologous recombination deficiency (HRD) testing on cell-free tumor DNA from peritoneal fluid
BackgroundKnowing the homologous recombination deficiency (HRD) status in advanced epithelial ovarian cancer (EOC) is vital for patient management....
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Using Sister Chromatid Exchange Assay to Detect Homologous Recombination Deficiency in Epigenetically Deregulated Urothelial Carcinoma Cells
Sister chromatid exchange (SCE) is the process of exchanging regions between two sister chromatids during DNA replication. Exchanges between...
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Intrachromosomal Recombination in Yeast
Spontaneous and induced mitotic recombinations are driven by lesions such as single-strand nicks and gaps and double-strand breaks in the genome. For...
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PRMT1 and PRMT5: on the road of homologous recombination and non-homologous end joining
DNA double-strand breaks (DSBs) are widely accepted to be the most deleterious form of DNA lesions that pose a severe threat to genome integrity. Two...
