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Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregation
The most common inherited cause of two genetically and clinico-pathologically overlap** neurodegenerative diseases, amyotrophic lateral sclerosis...
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Role of Genomics and Proteomics in Drug Discovery
Genomics and proteomics are two powerful technologies that are revolutionizing the drug discovery process. Genomics is the study of the entire genome...
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Proteomics to study cancer immunity and improve treatment
Cancer survival and progression depend on the ability of tumor cells to avoid immune recognition. Advances in the understanding of cancer immunity...
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Proteomics technologies for cancer liquid biopsies
Alterations in DNAs could not reveal what happened in proteins. The accumulated alterations of DNAs would change the manifestation of proteins....
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Recent advances in the detection of glioblastoma, from imaging-based methods to proteomics and biosensors: A narrative review
Glioblastoma (GBM) is an aggressive type of cancer that originates in the cells called astrocytes, which support the functioning of nerve cells. It...
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Proteomics in Huntington’s Disease Biomarker Discovery
Mass spectrometry (MS) and proteomics are continuously evolving methods in systems biology that carry enormous potential for accurately profiling the...
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Organ and cell-specific biomarkers of Long-COVID identified with targeted proteomics and machine learning
BackgroundSurvivors of acute COVID-19 often suffer prolonged, diffuse symptoms post-infection, referred to as “Long-COVID”. A lack of Long-COVID...
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Proximity extension assay in cerebrospinal fluid identifies neurofilament light chain as biomarker of neurodegeneration in sporadic cerebral amyloid angiopathy
BackgroundSporadic cerebral amyloid angiopathy (sCAA) is a disease characterised by the progressive deposition of the amyloid beta (Aβ) in the...
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The emerging role of mass spectrometry-based proteomics in drug discovery
Proteins are the main targets of most drugs; however, system-wide methods to monitor protein activity and function are still underused in drug...
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Combined Plasma Olink Proteomics and Transcriptomics Identifies CXCL1 and TNFRSF12A as Potential Predictive and Diagnostic Inflammatory Markers for Acute Kidney Injury
Acute kidney injury (AKI) poses a significant global public health challenge. Current methods for detecting AKI rely on monitoring changes in serum...
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The impact of circulating protein levels identified by affinity proteomics on short-term, overall breast cancer risk
ObjectiveCurrent breast cancer risk prediction scores and algorithms can potentially be further improved by including molecular markers. To this end,...
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Redox proteomics of PANC-1 cells reveals the significance of HIF-1 signaling protein oxidation in pancreatic ductal adenocarcinoma pathogenesis
BackgroundProtein cysteine oxidation is substantially involved in various biological and pathogenic processes, but its implications in pancreatic...
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Proximity Extension Assay (PEA) Platform to Detect Vitreous Biomarkers of Diabetic Retinopathy
Diabetic retinopathy (DR) is one of the leading causes of blindness, affecting more than 100 million people worldwide. Currently, DR prognosis and...
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In Vitro Oxygen Glucose Deprivation Model of Ischemic Stroke: A Proteomics-Driven Systems Biological Perspective
Oxygen glucose deprivation (OGD) of brain cells is the commonest in vitro model of ischemic stroke that is used extensively for basic and preclinical...
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A proteomics analysis of 5xFAD mouse brain regions reveals the lysosome-associated protein Arl8b as a candidate biomarker for Alzheimer’s disease
BackgroundAlzheimer’s disease (AD) is characterized by the intra- and extracellular accumulation of amyloid-β (Aβ) peptides. How Aβ aggregates...
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Identification of novel protein biomarkers from the blood and urine for the early diagnosis of bladder cancer via proximity extension analysis
BackgroundBladder cancer (BC) is a very common urinary tract malignancy that has a high incidence and lethality. In this study, we identified BC...
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Proteomic Analysis of C. Elegans Neurons Using TurboID-Based Proximity Labeling
The proteomes of specialized structures, and the interactomes of proteins of interest, provide entry points to elucidate the functions of molecular...
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Proteomics and Metabolomics in Cancer Diagnosis and Therapy
Cancer apparently seems to be incurable but a deeper introspection reveals other story. Cancer survival rate can be increased significantly with...
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Proteomics and Metabolomics in Cancer Diagnosis and Therapy
Cancer apparently seems to be incurable but a deeper introspection reveals other story. Cancer survival rate can be increased significantly with...