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Analysis of Protein Interactions in Patient-Derived Xenografts Using Immunoprecipitation
Proteins are large, complex molecules that regulate multiple functions within the cell. The protein rarely functions as a single molecule, but rather...
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Protein–protein interaction network-based integration of GWAS and functional data for blood pressure regulation analysis
BackgroundIt is valuable to analyze the genome-wide association studies (GWAS) data for a complex disease phenotype in the context of the...
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Deep-learning-enabled protein–protein interaction analysis for prediction of SARS-CoV-2 infectivity and variant evolution
Host–pathogen interactions and pathogen evolution are underpinned by protein–protein interactions between viral and host proteins. An understanding...
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FLIM-FRET Protein-Protein Interaction Assay
Fluorescence lifetime imaging performed under FRET conditions between two interacting molecules is a sensitive and robust way to quantify...
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Co-immunoprecipitation Assays to Detect Protein–Protein Interactions
Proteins usually do not function as monomers but rather perform their functions by interacting with themselves or other proteins....
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Co-Immunoprecipitation-Blotting: Analysis of Protein-Protein Interactions
Immunoprecipitation of protein complexes, also known as co-immunoprecipitation (Co-IP), is a powerful technique to analyze protein-protein...
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Protein-centric omics integration analysis identifies candidate plasma proteins for multiple autoimmune diseases
It remains challenging to translate the findings from genome-wide association studies (GWAS) of autoimmune diseases (AIDs) into interventional...
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Burst Phase Analysis of the Aggregation Prone α-synuclein Amyloid Protein
While some studies inferred that valid information can be retrieved for the refolding of proteins and consequent identification of folding...
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Protein–Protein Interaction Modelling with the Fragment Molecular Orbital Method
Fragment molecular orbital (FMO) method enables ab initio quantum-chemical calculations for biomolecular systems with high accuracy and moderate...
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N-Glycan Insertion for Probing Protein–Protein Interactions and Epitope Map**
Introducing an N-linked glycosylation motif into recombinant proteins at specific sites is a useful tool in probing protein–protein interactions and...
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Exploring gene network and protein interaction analysis of neurotrophin signaling pathway in ameloblastoma
Ameloblastoma is a non-cancerous but aggressive oral tumor emerging from odontogenic epithelial tissue involved during odontogenesis. Since there is...
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Thermofluor-Based Analysis of Protein Integrity and Ligand Interactions
Thermofluor is a fluorescence-based thermal shift assay, which measures temperature-induced protein unfolding and thereby yields valuable information...
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Immunoprecipitation Followed by Mass Spectrometry: An Approach for Identifying Host–Viral Protein–Protein Interactions
As obligate intracellular parasites, viruses rely on the efficient manipulation of the cell they invade in order to multiply and spread....
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Glycosaminoglycan Analysis: Purification, Structural Profiling, and GAG–Protein Interactions
Glycosaminoglycans (GAGs) are long, linear polysaccharides that are ubiquitously expressed on the cell surface and in the extracellular matrix of all...
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The Split-Luciferase Complementation Assay to Detect and Quantify Protein–Protein Interactions in Planta
Protein–protein interactions play a critical role in plant viral infection and defense responses against pathogens. This protocol provides a detailed...
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Associations of intakes of total protein, protein from dairy sources, and dietary calcium with risks of colorectal, breast, and prostate cancer: a prospective analysis in UK Biobank
BackgroundEvidence concerning intakes of protein or sources of dairy protein and risks of colorectal, breast, and prostate cancers is inconclusive.
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Association between NDRG1 protein expression and aggressive features of breast cancer: a systematic review and meta-analysis
BackgroundN-myc downstream-regulated gene-1 (NDRG1) is well-described as a potent metastasis suppressor, but its role in human breast cancer remains...
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Analysis of Cancer Cell Line Secretomes: A Complementary Source of Disease-Specific Protein Biomarkers
Various types of cancer cells enrich or condition the medium that they are cultured in by secreting or shedding proteins and small molecules. These...
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Integrated Proteomics and Protein Co-expression Network Analysis Identifies Novel Epileptogenic Mechanism in Mesial Temporal Lobe Epilepsy
Over 50 million people worldwide are affected by epilepsy, a common neurological disorder that has a high rate of drug resistance and diverse...
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GRAMM Web Server for Protein Docking
Prediction of the structure of protein complexes by docking methods is a well-established research field. The intermolecular energy landscapes in...