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Glucocorticoid Receptor Down-Regulation Affects Neural Stem Cell Proliferation and Hippocampal Neurogenesis
Dysregulation of the hypothalamic–pituitary–adrenal axis and abnormalities in the glucocorticoid receptor (GR) have been linked to major depressive...
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Andrographolide anti-proliferation and metastasis of hepatocellular carcinoma through LncRNA MIR22HG regulation
Hepatocellular carcinoma (HCC) treatment is a major challenge. Although andrographolide (Andro) has an anti-proliferation effect on HCC, its...
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AP4M1 as a prognostic biomarker associated with cell proliferation, migration and immune regulation in hepatocellular carcinoma
BackgroundAP4M1 is a protein-coding gene that plays a crucial role in transporter activity, recognition, and hereditary-associated diseases, but...
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The strict regulation of HIF-1α by non-coding RNAs: new insight towards proliferation, metastasis, and therapeutic resistance strategies
The hypoxic environment is prominently witnessed in most solid tumors and is associated with the promotion of cell proliferation,...
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NCAPG promotes the proliferation of hepatocellular carcinoma through the CKII-dependent regulation of PTEN
BackgroundNCAPG, non-SMC subunit in the concentrate I complex, might promote the proliferation of hepatocellular carcinoma (HCC), but the mechanism...
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Pan-KRAS inhibitors suppress proliferation through feedback regulation in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is currently one of the most lethal cancers worldwide. Several basic studies have confirmed that Kirsten rat...
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WTAP Mediates NUPR1 Regulation of LCN2 Through m6A Modification to Influence Ferroptosis, Thereby Promoting Breast Cancer Proliferation, Migration and Invasion
Ferroptosis is involved in various pathophysiological diseases, including triple-negative breast cancer (TNBC). Targeting ferroptosis is considered...
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HES1-mediated down-regulation of miR-138 sustains NOTCH1 activation and promotes proliferation and invasion in renal cell carcinoma
BackgroundAlthough the aberrant activation of NOTCH1 pathway causes a malignant progression of renal cell carcinoma (RCC), the precise molecular...
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HOXD9/miR-451a/PSMB8 axis is implicated in the regulation of cell proliferation and metastasis via PI3K/AKT signaling pathway in human anaplastic thyroid carcinoma
Anaplastic thyroid carcinoma (ATC) is a deadly disease with a poor prognosis. Thus, there is a pressing need to determine the mechanism of ATC...
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microRNA-622 upregulates cell cycle process by targeting FOLR2 to promote CRC proliferation
BackgroundEpigenetic alterations contribute greatly to the development and progression of colorectal cancer, and effect of aberrant miR-622...
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Adult Glial Cell Proliferation and Neurogenesis
The nomenclature of stem and progenitor cells is reviewed. In the adult body, only glial cells and not neurons can proliferate. The glial cell with...
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STEAP3 promotes colon cancer cell proliferation and migration via regulating histone acetylation
Colorectal cancer (CRC) is the third most prevalent diagnosed cancer in men and second most prevalent cancer in women. H3K27ac alterations are more...
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2′,3′,4′-Trihydroxychalcone changes estrogen receptor α regulation of genes and breast cancer cell proliferation by a reprogramming mechanism
BackgroundMenopausal hormone therapy (MHT) is recommended for only five years to treat vasomotor symptoms and vulvovaginal atrophy because of safety...
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Cancer as a Disease of Cell Proliferation
Evolutionary dynamics relates the growth and development of tumours to changes in rates of cell proliferation and cell death, and to their mutation...
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CircRAD23B promotes proliferation and carboplatin resistance in ovarian cancer cell lines and organoids
BackgroundCircular RNAs (circRNAs) are involved in the regulation of progression and drug resistance in ovarian cancer (OC). In the present study, we...
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BCAT1 controls embryonic neural stem cells proliferation and differentiation in the upper layer neurons
The regulation of neural stem cell (NSC) proliferation and differentiation during brain development is a precisely controlled process, with the...
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Yap/Taz activity is associated with increased expression of phosphoglycerate dehydrogenase that supports myoblast proliferation
In skeletal muscle, the Hippo effector Yap promotes satellite cell, myoblast, and rhabdomyoblast proliferation but prevents myogenic differentiation...
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MicroRNA regulation of the proliferation and apoptosis of Leydig cells in diabetes
BackgroundThe number of patients with diabetes is increasing worldwide. Diabetic testicular damage can cause spermiogenesis disorders and sexual...
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Angiogenin as a Possible Mediator of Macrophage-Mediated Regulation of Fibroblast Functions
We studied angiogenin production by human macrophages and evaluated the role of this factor in the macrophage-mediated regulation of fibroblasts. All...
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USP2 Promotes the Proliferation and Inflammation of Fibroblast-Like Synovial Cells in Rheumatoid Arthritis Through Deubiquitination of TRAF2
Rheumatoid arthritis (RA) is a prevalent inflammatory disorder affecting about 1% of the global population. The ubiquitin-specific protease 2 (USP2)...
